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  • Vaidya, J., Wenz, F., Bulsara, M., Tobias, J., Joseph, D., Keshtgar, M., Flyger, H., Massarut, S., Alvarado, M., Saunders, C., Eiermann, W., Metaxas, M., Sperk, E., Sütterlin, M., Brown, D., Esserman, L., Roncadin, M., Thompson, A., Dewar, J., Holtveg, H., Pigorsch, S., Falzon, M., Harris, E., Matthews, A., Brew-Graves, C., Potyka, I., Corica, T., Williams, N. & Baum, M. (2013) Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. IN The Lancet, .. doi:10.1016/s0140-6736(13)61950-9
    [BibTeX] [Abstract] [Download PDF]

    Background The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam radiotherapy (EBRT) for breast cancer. We report 5-year results for local recurrence and the first analysis of overall survival. Methods TARGIT-A was a randomised, non-inferiority trial. Women aged 45 years and older with invasive ductal carcinoma were enrolled and randomly assigned in a 1:1 ratio to receive TARGIT or whole-breast EBRT, with blocks stratified by centre and by timing of delivery of targeted intraoperative radiotherapy: randomisation occurred either before lumpectomy (prepathology stratum, TARGIT concurrent with lumpectomy) or after lumpectomy (postpathology stratum, TARGIT given subsequently by reopening the wound). Patients in the TARGIT group received supplemental EBRT (excluding a boost) if unforeseen adverse features were detected on final pathology, thus radiotherapy was risk-adapted. The primary outcome was absolute difference in local recurrence in the conserved breast, with a prespecified non-inferiority margin of 2·5% at 5 years; prespecified analyses included outcomes as per timing of randomisation in relation to lumpectomy. Secondary outcomes included complications and mortality. This study is registered with ClinicalTrials.gov, number NCT00983684. Findings Patients were enrolled at 33 centres in 11 countries, between March 24, 2000, and June 25, 2012. 1721 patients were randomised to TARGIT and 1730 to EBRT. Supplemental EBRT after TARGIT was necessary in 15·2% [239 of 1571] of patients who received TARGIT (21·6% prepathology, 3·6% postpathology). 3451 patients had a median follow-up of 2 years and 5 months (IQR 12–52 months), 2020 of 4 years, and 1222 of 5 years. The 5-year risk for local recurrence in the conserved breast was 3·3% (95% CI 2·1–5·1) for TARGIT versus 1·3% (0·7–2·5) for EBRT (p=0·042). TARGIT concurrently with lumpectomy (prepatholog

    @article{vaidya2013risk-adaptedtrial,
    author = "Vaidya, JS and Wenz, F and Bulsara, M and Tobias, JS and Joseph, DJ and Keshtgar, M and Flyger, HL and Massarut, S and Alvarado, M and Saunders, C and Eiermann, W and Metaxas, M and Sperk, E and Sütterlin, M and Brown, D and Esserman, L and Roncadin, M and Thompson, A and Dewar, JA and Holtveg, HMR and Pigorsch, S and Falzon, M and Harris, E and Matthews, A and Brew-Graves, C and Potyka, I and Corica, T and Williams, NR and Baum, M",
    journal = "The Lancet",
    month = "Nov",
    title = "Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial",
    url = "http://goo.gl/J0PEKU",
    year = "2013",
    abstract = "Background The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam radiotherapy (EBRT) for breast cancer. We report 5-year results for local recurrence and the first analysis of overall survival.
    Methods TARGIT-A was a randomised, non-inferiority trial. Women aged 45 years and older with invasive ductal carcinoma were enrolled and randomly assigned in a 1:1 ratio to receive TARGIT or whole-breast EBRT, with blocks stratified by centre and by timing of delivery of targeted intraoperative radiotherapy: randomisation occurred either before lumpectomy (prepathology stratum, TARGIT concurrent with lumpectomy) or after lumpectomy (postpathology stratum, TARGIT given subsequently by reopening the wound). Patients in the TARGIT group received supplemental EBRT (excluding a boost) if unforeseen adverse features were detected on final pathology, thus radiotherapy was risk-adapted. The primary outcome was absolute difference in local recurrence in the conserved breast, with a prespecified non-inferiority margin of 2·5% at 5 years; prespecified analyses included outcomes as per timing of randomisation in relation to lumpectomy. Secondary outcomes included complications and mortality. This study is registered with ClinicalTrials.gov, number NCT00983684.
    Findings Patients were enrolled at 33 centres in 11 countries, between March 24, 2000, and June 25, 2012. 1721 patients were randomised to TARGIT and 1730 to EBRT. Supplemental EBRT after TARGIT was necessary in 15·2% [239 of 1571] of patients who received TARGIT (21·6% prepathology, 3·6% postpathology). 3451 patients had a median follow-up of 2 years and 5 months (IQR 12–52 months), 2020 of 4 years, and 1222 of 5 years. The 5-year risk for local recurrence in the conserved breast was 3·3% (95% CI 2·1–5·1) for TARGIT versus 1·3% (0·7–2·5) for EBRT (p=0·042). TARGIT concurrently with lumpectomy (prepathology, n=2298) had much the same results as EBRT: 2·1% (1·1–4·2) versus 1·1% (0·5–2·5; p=0·31). With delayed TARGIT (postpathology, n=1153) the between-group difference was larger than 2·5% (TARGIT 5·4% [3·0–9·7] vs EBRT 1·7% [0·6–4·9]; p=0·069). Overall, breast cancer mortality was much the same between groups (2·6% [1·5–4·3] for TARGIT vs 1·9% [1·1–3·2] for EBRT; p=0·56) but there were significantly fewer non-breast-cancer deaths with TARGIT (1·4% [0·8–2·5] vs 3·5% [2·3–5·2]; p=0·0086), attributable to fewer deaths from cardiovascular causes and other cancers. Overall mortality was 3·9% (2·7–5·8) for TARGIT versus 5·3% (3·9–7·3) for EBRT (p=0·099). Wound-related complications were much the same between groups but grade 3 or 4 skin complications were significantly reduced with TARGIT (four of 1720 vs 13 of 1731, p=0·029).
    Interpretation TARGIT concurrent with lumpectomy within a risk-adapted approach should be considered as an option for eligible patients with breast cancer carefully selected as per the TARGIT-A trial protocol, as an alternative to postoperative EBRT.",
    doi = "10.1016/s0140-6736(13)61950-9",
    issn = "0140-6736",
    keyword = "TARGIT",
    keyword = "IORT",
    keyword = "Intraoperative radiotherapy",
    keyword = "radiotherapy",
    keyword = "breast cancer",
    keyword = "lumpectomy",
    day = "11",
    }

  • Wenz, F., Vaidya, J., Pigorsch, S., Feyer, P., Roedel, C., Belka, C., Fleckenstein, J., Bremer, M., Joseph, D. & Baum, M. (2013) Local Recurrence and Survival for the German Centers in the TARGIT-A (TARGeted Intraoperative Radiation Therapy – Alone) Trial. IN International Journal of Radiation Oncology*Biology*Physics, 87.S241. doi:10.1016/j.ijrobp.2013.06.625
    [BibTeX] [Download PDF]
    @article{wenz2013localtrial,
    author = "Wenz, F and Vaidya, JS and Pigorsch, S and Feyer, P and Roedel, C and Belka, C and Fleckenstein, J and Bremer, M and Joseph, D and Baum, M",
    journal = "International Journal of Radiation Oncology*Biology*Physics",
    month = "Oct",
    note = "",
    pages = "S241",
    title = "Local Recurrence and Survival for the German Centers in the TARGIT-A (TARGeted Intraoperative Radiation Therapy - Alone) Trial",
    url = "http://www.sciencedirect.com/science/article/pii/S0360301613012959",
    volume = "87",
    year = "2013",
    doi = "10.1016/j.ijrobp.2013.06.625",
    issn = "0360-3016",
    issue = "2, Supplement",
    conference = "Proceedings of the American Society for Radiation Oncology 55th Annual Meeting ASTRO's 55th Annual Metting",
    day = "1",
    }

  • Vaidya, J., Bulsara, M., Wenz, F., Massarut, S., Joseph, D., Tobias, J., Williams, N. & Baum, M. (2013) The Lower Non-Breast Cancer Mortality With TARGIT in the TARGIT-A Trial Could Be a Systemic Effect of TARGIT on Tumor Microenvironment. IN International Journal of Radiation Oncology*Biology*Physics, 87.S240. doi:10.1016/j.ijrobp.2013.06.623
    [BibTeX] [Download PDF]
    @article{vaidya2013themicroenvironment,
    author = "Vaidya, JS and Bulsara, M and Wenz, F and Massarut, S and Joseph, D and Tobias, J and Williams, N and Baum, M",
    journal = "International Journal of Radiation Oncology*Biology*Physics",
    month = "Oct",
    note = "",
    pages = "S240",
    title = "The Lower Non-Breast Cancer Mortality With TARGIT in the TARGIT-A Trial Could Be a Systemic Effect of TARGIT on Tumor Microenvironment",
    url = "http://www.sciencedirect.com/science/article/pii/S0360301613012935",
    volume = "87",
    year = "2013",
    doi = "10.1016/j.ijrobp.2013.06.623",
    issn = "0360-3016",
    issue = "2, Supplement",
    conference = "Proceedings of the American Society for Radiation Oncology 55th Annual Meeting ASTRO's 55th Annual Metting",
    day = "1",
    }

  • Vaidya, J., Wenz, F., Bulsara, M., Massarut, S., Tobias, J., Williams, N., Joseph, D. & Baum, M. (2013) Omitting Whole Breast Radiation Therapy did not Increase Axillary Recurrence in the TARGIT-A Trial. IN International Journal of Radiation Oncology*Biology*Physics, 87.S7. doi:10.1016/j.ijrobp.2013.06.025
    [BibTeX] [Download PDF]
    @article{vaidya2013omittingtrial,
    author = "Vaidya, JS and Wenz, F and Bulsara, M and Massarut, S and Tobias, J and Williams, N and Joseph, D and Baum, M",
    journal = "International Journal of Radiation Oncology*Biology*Physics",
    month = "Oct",
    note = "",
    pages = "S7",
    title = "Omitting Whole Breast Radiation Therapy did not Increase Axillary Recurrence in the TARGIT-A Trial",
    url = "http://www.sciencedirect.com/science/article/pii/S0360301613006950",
    volume = "87",
    year = "2013",
    doi = "10.1016/j.ijrobp.2013.06.025",
    issn = "0360-3016",
    issue = "2, Supplement",
    conference = "Proceedings of the American Society for Radiation Oncology 55th Annual Meeting ASTRO's 55th Annual Metting",
    day = "1",
    }

  • Vaidya, J. (2013) Case selection for targeted intraoperative radiotherapy (TARGIT) .
    [BibTeX] [Abstract]

    Background: The TARGIT-A randomised trial compared a risk-adapted approach using targeted intraoperative radiotherapy (TARGIT) with whole breast external beam radiotherapy (EBRT) after lumpectomy for early breast cancer. At the San Antonio update, it was suggested that the preferred option is to give TARGIT concurrently with lumpectomy (prepathology). In this analysis we describe patient and tumour factors that may help select patients for TARGIT based on the results of an a priori statistical analysis plan. Methods: In this large international trial, 3451 patients (age>=45, unifocal invasive ductal carcinoma, size 3.5 cm) from 33 centres in 10 countries were randomly allocated to either TARGIT or EBRT. Primary outcome was ipsilateral breast recurrence and secondary included mortality. Before unblinding for this analysis, we hypothesised that progesterone receptor (PgR) status, as an expression of a functionally active oestrogen receptor (ER), is a surrogate for radiation responsiveness and could predict a difference between the outcome for local control in the two randomised groups and pre-specified a detailed analysis by PgR status. We also assessed whether a Cox proportional hazard model including age, margin status, tumour grade, ER, PgR, HER2, vascular invasion and node positivity was consistent with our results. Results: For PgR positive cases, there was no significant difference in the primary outcome of Ipsilateral breast recurrence between TARGIT and EBRT (2.3%(1.3−4.3) vs. 1.5%(0.75−3.0) p = 0.51, while in PgR negative cases there were significantly more local recurrences after partial breast irradiation using TARGIT: 7.0%(3.5–13.6) vs. 0.5%(0.1−3.7) p = 0.017. By contrast, age, margin status, tumour grade, tumour size, vascular invasion, node positivity, ER and Her2 status were not found to be significant predictors. Even age younger than 50 or grade 3 cancers had similar outcome with TARGIT or EBRT. Exploratory analyses in conjunction with the timing of TARGIT, revealed that when TARGIT was given concurrently in PgR positive cases (n=1625) the results were (TARGIT vs. EBRT): ipsilateral breast recurrence 4 vs. 5, 5-year risk 1.4%(0.46−3.9) vs. 1.2%(0.48−2.9) HR 0.82(0.22–3.06), and overall mortality 18 vs. 31, 5-year risk 3.3%(1.83–6.04) vs. 6.4%(4.3−9.6) HR 0.60(0.34–1.08). Conclusions: It appears that progesterone receptor status is useful in selecting cases for using the TARGIT concurrently with lumpectomy for breast cancer. Progesterone receptor negative patients may fall in the cautious or unsuitable category and progesterone receptor positive cases are in the suitable category for partial breast irradiation with TARGIT. Conflict of interest: Other substantive relationships: Carl Zeiss (travel to meetings and honoraria).

    @misc{vaidya2013casetargit,
    author = "Vaidya, JS",
    month = "Sep",
    organization = "Amsterdam, Netherlands",
    title = "Case selection for targeted intraoperative radiotherapy (TARGIT)",
    year = "2013",
    abstract = "Background: The TARGIT-A randomised trial compared a risk-adapted approach using targeted intraoperative radiotherapy (TARGIT) with whole breast external beam radiotherapy (EBRT) after lumpectomy for early breast cancer. At the San Antonio update, it was suggested that the preferred option is to give TARGIT concurrently with lumpectomy (prepathology). In this analysis we describe patient and tumour factors that may help select patients for TARGIT based on the results of an a priori statistical analysis plan. Methods: In this large international trial, 3451 patients (age>=45, unifocal invasive ductal carcinoma, size 3.5 cm) from 33 centres in 10 countries were randomly allocated to either TARGIT or EBRT. Primary outcome was ipsilateral breast recurrence and secondary included mortality. Before unblinding for this analysis, we hypothesised that progesterone receptor (PgR) status, as an expression of a functionally active oestrogen receptor (ER), is a surrogate for radiation responsiveness and could predict a difference between the outcome for local control in the two randomised groups and pre-specified a detailed analysis by PgR status. We also assessed whether a Cox proportional hazard model including age, margin status, tumour grade, ER, PgR, HER2, vascular invasion and node positivity was consistent with our results. Results: For PgR positive cases, there was no significant difference in the primary outcome of Ipsilateral breast recurrence between TARGIT and EBRT (2.3%(1.3−4.3) vs. 1.5%(0.75−3.0) p = 0.51, while in PgR negative cases there were significantly more local recurrences after partial breast irradiation using TARGIT: 7.0%(3.5–13.6) vs. 0.5%(0.1−3.7) p = 0.017. By contrast, age, margin status, tumour grade, tumour size, vascular invasion, node positivity, ER and Her2 status were not found to be significant predictors. Even age younger than 50 or grade 3 cancers had similar outcome with TARGIT or EBRT. Exploratory analyses in conjunction with the timing of TARGIT, revealed that when TARGIT was given concurrently in PgR positive cases (n=1625) the results were (TARGIT vs. EBRT): ipsilateral breast recurrence 4 vs. 5, 5-year risk 1.4%(0.46−3.9) vs. 1.2%(0.48−2.9) HR 0.82(0.22–3.06), and overall mortality 18 vs. 31, 5-year risk 3.3%(1.83–6.04) vs. 6.4%(4.3−9.6) HR 0.60(0.34–1.08). Conclusions: It appears that progesterone receptor status is useful in selecting cases for using the TARGIT concurrently with lumpectomy for breast cancer. Progesterone receptor negative patients may fall in the cautious or unsuitable category and progesterone receptor positive cases are in the suitable category for partial breast irradiation with TARGIT. Conflict of interest: Other substantive relationships: Carl Zeiss (travel to meetings and honoraria).",
    keyword = "TARGIT",
    keyword = "TARGIT-A Trial",
    keyword = "Breast cancer",
    keyword = "IORT",
    keyword = "Intraoperative radiotherapy",
    keyword = "Progesterone",
    keyword = "Hormone receptor stauts",
    keyword = "PgR status",
    keyword = "Case selection",
    language = "English",
    conference = "European Cancer Congress 2013 (ECCO-ESMO-ESTRO)",
    day = "27",
    }

  • Vaidya, J., Wenz, F., Bulsara, M., Tobias, J., Massarut, S., Joseph, D. & Baum, M. (2013) Case selection for targeted intraoperative radiotherapy (TARGIT). IN European Journal of Cancer, 49, Supplement 2.S451. doi:10.1016/S0959-8049(13)70063-7
    [BibTeX] [Abstract] [Download PDF]

    Background: The TARGIT-A randomised trial compared a risk-adapted approach using targeted intraoperative radiotherapy (TARGIT) with whole breast external beam radiotherapy (EBRT) after lumpectomy for early breast cancer. At the San Antonio update, it was suggested that the preferred option is to give TARGIT concurrently with lumpectomy (prepathology). In this analysis we describe patient and tumour factors that may help select patients for TARGIT based on the results of an a priori statistical analysis plan. Methods: In this large international trial, 3451 patients (age>=45, unifocal invasive ductal carcinoma, size 3.5 cm) from 33 centres in 10 countries were randomly allocated to either TARGIT or EBRT. Primary outcome was ipsilateral breast recurrence and secondary included mortality. Before unblinding for this analysis, we hypothesised that progesterone receptor (PgR) status, as an expression of a functionally active oestrogen receptor (ER), is a surrogate for radiation responsiveness and could predict a difference between the outcome for local control in the two randomised groups and pre-specified a detailed analysis by PgR status. We also assessed whether a Cox proportional hazard model including age, margin status, tumour grade, ER, PgR, HER2, vascular invasion and node positivity was consistent with our results. Results: For PgR positive cases, there was no significant difference in the primary outcome of Ipsilateral breast recurrence between TARGIT and EBRT (2.3%(1.3−4.3) vs. 1.5%(0.75−3.0) p = 0.51, while in PgR negative cases there were significantly more local recurrences after partial breast irradiation using TARGIT: 7.0%(3.5–13.6) vs. 0.5%(0.1−3.7) p = 0.017. By contrast, age, margin status, tumour grade, tumour size, vascular invasion, node positivity, ER and Her2 status were not found to be significant predictors. Even age younger than 50 or grade 3 cancers had similar outcome with TARGIT or EBRT. Exploratory analyses in conjunction with the timing of TARGIT, revealed that when TARGIT was given concurrently in PgR positive cases (n=1625) the results were (TARGIT vs. EBRT): ipsilateral breast recurrence 4 vs. 5, 5-year risk 1.4%(0.46−3.9) vs. 1.2%(0.48−2.9) HR 0.82(0.22–3.06), and overall mortality 18 vs. 31, 5-year risk 3.3%(1.83–6.04) vs. 6.4%(4.3−9.6) HR 0.60(0.34–1.08). Conclusions: It appears that progesterone receptor status is useful in selecting cases for using the TARGIT concurrently with lumpectomy for breast cancer. Progesterone receptor negative patients may fall in the cautious or unsuitable category and progesterone receptor positive cases are in the suitable category for partial breast irradiation with TARGIT. Conflict of interest: Other substantive relationships: Carl Zeiss (travel to meetings and honoraria).

    @article{vaidya2013casetargit,
    author = "Vaidya, JS and Wenz, F and Bulsara, M and Tobias, JS and Massarut, S and Joseph, D and Baum, M",
    journal = "European Journal of Cancer",
    month = "Sep",
    pages = "S451",
    title = "Case selection for targeted intraoperative radiotherapy (TARGIT)",
    url = "http://www.sciencedirect.com/science/article/pii/S0959804913700637",
    volume = "49, Supplement 2",
    year = "2013",
    abstract = "Background: The TARGIT-A randomised trial compared a risk-adapted approach using targeted intraoperative radiotherapy (TARGIT) with whole breast external beam radiotherapy (EBRT) after lumpectomy for early breast cancer. At the San Antonio update, it was suggested that
    the preferred option is to give TARGIT concurrently with lumpectomy (prepathology). In this analysis we describe patient and tumour factors that may help select patients for TARGIT based on the results of an a priori statistical analysis plan.
    Methods: In this large international trial, 3451 patients (age>=45, unifocal invasive ductal carcinoma, size 3.5 cm) from 33 centres in 10 countries were randomly allocated to either TARGIT or EBRT. Primary outcome was ipsilateral breast recurrence and secondary included mortality. Before unblinding for this analysis, we hypothesised that progesterone receptor (PgR) status, as an expression of a functionally active oestrogen receptor (ER), is a surrogate for radiation responsiveness and could predict a difference between the outcome for local control in the two randomised groups and pre-specified a detailed analysis by PgR status. We also assessed whether a Cox proportional hazard model including age, margin status, tumour grade, ER, PgR, HER2, vascular invasion and node positivity was consistent with our results.
    Results: For PgR positive cases, there was no significant difference in the primary outcome of Ipsilateral breast recurrence between TARGIT and EBRT (2.3%(1.3−4.3) vs. 1.5%(0.75−3.0) p = 0.51, while in PgR negative cases there were significantly more local recurrences after partial breast irradiation using TARGIT: 7.0%(3.5–13.6) vs. 0.5%(0.1−3.7) p = 0.017. By contrast, age, margin status, tumour grade, tumour size, vascular invasion, node positivity, ER and Her2 status were not found to be significant predictors. Even age younger than 50 or grade 3 cancers had similar outcome with TARGIT or EBRT. Exploratory analyses in conjunction with the timing of TARGIT, revealed that when TARGIT was given concurrently in PgR positive cases (n=1625) the results were (TARGIT vs. EBRT): ipsilateral breast recurrence 4 vs. 5, 5-year risk 1.4%(0.46−3.9) vs. 1.2%(0.48−2.9) HR 0.82(0.22–3.06), and overall mortality 18 vs. 31, 5-year risk 3.3%(1.83–6.04) vs. 6.4%(4.3−9.6) HR 0.60(0.34–1.08). Conclusions: It appears that progesterone receptor status is useful in selecting cases for using the TARGIT concurrently with lumpectomy for breast cancer. Progesterone receptor negative patients may fall in the cautious or unsuitable category and progesterone receptor positive cases are in the suitable category for partial breast irradiation with TARGIT. Conflict of interest: Other substantive relationships: Carl Zeiss (travel to meetings and honoraria).",
    doi = "10.1016/S0959-8049(13)70063-7",
    issn = "0959-8049",
    issue = "0",
    keyword = "TARGIT",
    keyword = "TARGIT-A Trial",
    keyword = "breast cancer",
    keyword = "IORT",
    keyword = "intraoperative radiotherapy",
    keyword = "progesterone",
    keyword = "hormone receptor stauts",
    keyword = "PgR status",
    keyword = "Case selection",
    conference = "European Cancer Congress 2013 Abstract Book",
    publicationstatus = "published",
    }

  • Retsky, M., Demicheli, R., Hrushesky, W., Forget, P., DeKock, M., Gukas, I., Rogers, R., Baum, M., Sukhatme, V. & Vaidya, J. (2013) Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review. .
    [BibTeX] [Abstract] [Download PDF]

    To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients identified in multiple databases, we proposed that late relapses result from steady stochastic progressions from single dormant malignant cells to avascular micrometastases and then on to growing deposits. However in order to explain early relapses, we had to postulate that something happens at about the time of surgery to provoke sudden exits from dormant phases to active growth and then to detection. Most relapses in breast cancer are in the early category. Recent data from Forget et al suggests an unexpected mechanism. They retrospectively studied results from 327 consecutive breast cancer patients comparing various perioperative analgesics and anesthetics in one Belgian hospital and one surgeon. Patients were treated with mastectomy and conventional adjuvant therapy. Relapse hazard updated Sept 2011 are presented. A common Non-Steroidal Anti-Inflammatory Drug (NSAID) analgesic used in surgery produced far superior disease-free survival in the first 5 years after surgery. The expected prominent early relapse events in months 9-18 are reduced 5-fold. If this observation holds up to further scrutiny, it could mean that the simple use of this safe, inexpensive and effective anti-inflammatory agent at surgery might eliminate early relapses. Transient systemic inflammation accompanying surgery could facilitate angiogenesis of dormant micrometastases, proliferation of dormant single cells, and seeding of circulating cancer stem cells (perhaps in part released from bone marrow) resulting in early relapse and could have been effectively blocked by the perioperative anti-inflammatory agent.

    @article{retsky2013reductionreview,
    author = "Retsky, MW and Demicheli, R and Hrushesky, WJM and Forget, P and DeKock, M and Gukas, I and Rogers, RA and Baum, M and Sukhatme, V and Vaidya, JS",
    journal = "",
    month = "Aug",
    note = "25 pages, 10 figures, in press; Current Medicinal Chemistry, May 2013",
    title = "Reduction of breast cancer relapses with perioperative non-steroidal
    anti-inflammatory drugs: new findings and a review",
    url = "http://arxiv.org/abs/1308.3690v1",
    year = "2013",
    abstract = "To explain a bimodal pattern of hazard of relapse among early stage breast
    cancer patients identified in multiple databases, we proposed that late
    relapses result from steady stochastic progressions from single dormant
    malignant cells to avascular micrometastases and then on to growing deposits.
    However in order to explain early relapses, we had to postulate that something
    happens at about the time of surgery to provoke sudden exits from dormant
    phases to active growth and then to detection. Most relapses in breast cancer
    are in the early category. Recent data from Forget et al suggests an unexpected
    mechanism. They retrospectively studied results from 327 consecutive breast
    cancer patients comparing various perioperative analgesics and anesthetics in
    one Belgian hospital and one surgeon. Patients were treated with mastectomy and
    conventional adjuvant therapy. Relapse hazard updated Sept 2011 are presented.
    A common Non-Steroidal Anti-Inflammatory Drug (NSAID) analgesic used in surgery
    produced far superior disease-free survival in the first 5 years after surgery.
    The expected prominent early relapse events in months 9-18 are reduced 5-fold.
    If this observation holds up to further scrutiny, it could mean that the simple
    use of this safe, inexpensive and effective anti-inflammatory agent at surgery
    might eliminate early relapses. Transient systemic inflammation accompanying
    surgery could facilitate angiogenesis of dormant micrometastases, proliferation
    of dormant single cells, and seeding of circulating cancer stem cells (perhaps
    in part released from bone marrow) resulting in early relapse and could have
    been effectively blocked by the perioperative anti-inflammatory agent.",
    day = "16",
    }

  • Vaidya, J., Bulsara, M. & Wenz, F. (2013) Ischemic heart disease after breast cancer radiotherapy.. IN N Engl J Med, 368.2526-2527. doi:10.1056/NEJMc1304601#SA5
    [BibTeX] [Download PDF]
    @article{vaidya2013ischemicradiotherapy.,
    author = "Vaidya, JS and Bulsara, M and Wenz, F",
    journal = "N Engl J Med",
    month = "Jun",
    organization = "United States",
    pages = "2526--2527",
    title = "Ischemic heart disease after breast cancer radiotherapy.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/23802528",
    volume = "368",
    year = "2013",
    doi = "10.1056/NEJMc1304601#SA5",
    eissn = "1533-4406",
    issue = "26",
    language = "eng",
    day = "27",
    }

  • Vaidya, J., Bulsara, M., Wenz, F., Massarut, S., Joseph, D., Tobias, J., Williams, N., Baum, M. & Grp, T. (2013) OMISSION OF WHOLE BREAST RADIOTHERAPY DOES NOT INCREASE AXILLARY RECURRENCE – DATA FROM TARGIT-A TRIAL , S96–S96.
    [BibTeX] [Download PDF]
    @inproceedings{vaidya2013omissiontrial,
    author = "Vaidya, JS and Bulsara, M and Wenz, F and Massarut, S and Joseph, D and Tobias, J and Williams, NR and Baum, M and Grp, TARGITT",
    booktitle = "BREAST",
    month = "Mar",
    pages = "S96--S96",
    title = "OMISSION OF WHOLE BREAST RADIOTHERAPY DOES NOT INCREASE AXILLARY RECURRENCE - DATA FROM TARGIT-A TRIAL",
    url = "http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2\\&SrcApp=PARTNER_APP\\&SrcAuth=LinksAMR\\&KeyUT=000317634800253\\&DestLinkType=FullRecord\\&DestApp=ALL_WOS\\&UsrCustomerID=f41074198c063036414efcbc916f8956",
    volume = "22",
    year = "2013",
    issn = "0960-9776",
    }

  • Vaidya, J., Bulsara, M., Wenz, F., Massarut, S., Joseph, D., Tobias, J., Williams, N. & Baum, M. (2013) FEWER NON-BREAST CANCER DEATHS IN TARGIT-A TRIAL: SYSTEMIC BENEFIT OF TARGIT OR LACK OF EBRT TOXICITY. IN BREAST, 22.S97–S97.
    [BibTeX] [Download PDF]
    @article{vaidya2013fewertoxicity,
    author = "Vaidya, JS and Bulsara, M and Wenz, F and Massarut, S and Joseph, D and Tobias, J and Williams, NR and Baum, M",
    journal = "BREAST",
    month = "Mar",
    pages = "S97--S97",
    title = "FEWER NON-BREAST CANCER DEATHS IN TARGIT-A TRIAL: SYSTEMIC BENEFIT OF TARGIT OR LACK OF EBRT TOXICITY",
    url = "http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2\\&SrcApp=PARTNER_APP\\&SrcAuth=LinksAMR\\&KeyUT=000317634800254\\&DestLinkType=FullRecord\\&DestApp=ALL_WOS\\&UsrCustomerID=f41074198c063036414efcbc916f8956",
    volume = "22",
    year = "2013",
    issn = "0960-9776",
    }

  • Vaidya, J., Benson, J. & Tobias, J. (2013) Targeted therapy for breast cancer: not all cancers will grow. IN Benson, J., Gui, G. & Tuttle, T. (Eds.), Early Breast Cancer: From screening to multidisciplinary management. 3rd ed..
    [BibTeX] [Download PDF]
    @incollection{vaidya2013targetedgrow,
    author = "Vaidya, JS and Benson, JR and Tobias, JS",
    booktitle = "Early Breast Cancer: From screening to multidisciplinary management",
    edition = "3rd",
    editor = "Benson, JR and Gui, G and Tuttle, TM",
    number = "43",
    publisher = "CRC Press, Taylor Francis Group",
    school = "London",
    title = "Targeted therapy for breast cancer: not all cancers will grow",
    url = "http://www.taylorandfrancis.com/",
    year = "2013",
    keyword = "Breast cancer, intraoperative radiotherapy",
    language = "978-1-84184-885-3 (Hardback); 978-1-84184-886-0 (eBook)",
    }

  • Vaidya, J. (2013) Should healthy populations be screened for breast cancer? A consultant surgeon’s perspective.. IN Qual Prim Care, 21.189-192.
    [BibTeX] [Download PDF]
    @article{vaidya2013shouldperspective.,
    address = "Division of Surgery and Interventional Science, 2nd Floor Clerkenwell Building, University College London, Highgate Hill, London N19 5LW, UCL Hospital and Royal Free Hospitals, UK. jayantvaidya@gmail.com.",
    author = "Vaidya, JS",
    journal = "Qual Prim Care",
    organization = "England",
    pages = "189--192",
    title = "Should healthy populations be screened for breast cancer? A consultant surgeon's perspective.",
    url = "http://jayantvaidya.org/blog/?p=7",
    url = "http://www.radcliffehealth.com/journals",
    volume = "21",
    year = "2013",
    issn = "1479-1072",
    issue = "3",
    language = "eng",
    publicationstatus = "published",
    }

  • Vaidya, J., Wenz, F., Bulsara, M., Joseph, D., Tobias, J., Kesthgar, M., Flyger, H., Massarut, S., Alvarado, M., Saunders, C., Eiermann, W., Metaxas, M., Sperk, E., Sutterlin, M., Brown, D., Esserman, L., Roncadin, M., Thompson, A., Dewar, J., Holtveg, H., Pigorsch, S., Falzon, M., Harris, E., Matthews, A., Brew-Graves, C., Potyka, I., Corica, T., Williams, N. & Baum, M. (2012) Targeted intraoperative radiotherapy for early breast cancer: TARGIT-A trial- updated analysis of local recurrence and first analysis of survival . doi:10.1158/0008-5472.SABCS12-S4-2
    [BibTeX] [Download PDF]
    @inproceedings{vaidya2012targetedsurvival,
    author = "Vaidya, JS and Wenz, F and Bulsara, M and Joseph, D and Tobias, JS and Kesthgar, M and Flyger, H and Massarut, S and Alvarado, M and Saunders, C and Eiermann, W and Metaxas, M and Sperk, E and Sutterlin, M and Brown, D and Esserman, L and Roncadin, M and Thompson, A and Dewar, JA and Holtveg, H and Pigorsch, S and Falzon, M and Harris, E and Matthews, A and Brew-Graves, C and Potyka, I and Corica, T and Williams, N and Baum, M",
    booktitle = "Cancer Research",
    month = "Dec",
    organization = "San Antonio",
    title = "Targeted intraoperative radiotherapy for early breast cancer: TARGIT-A trial- updated analysis of local recurrence and first analysis of survival",
    url = "http://www.targit.org.uk/",
    url = "http://goo.gl/4E10I",
    volume = "72",
    year = "2012",
    doi = "10.1158/0008-5472.SABCS12-S4-2",
    startyear = "2012",
    startmonth = "Dec",
    startday = "4",
    finishyear = "2012",
    finishmonth = "Dec",
    finishday = "8",
    issue = "24 Supplement 3",
    keyword = "TARGIT",
    keyword = "IORT",
    keyword = "Breast Cancer",
    keyword = "Radiotherapy",
    keyword = "Radiation therapy",
    keyword = "Targeted Intraoperative radiotherapy",
    conference = "San Antonio Breast Cancer Conference",
    }

  • Vaidya, J. (2012) BBC News (Live TV) .
    [BibTeX]
    @misc{vaidya2012bbctv,
    author = "Vaidya, JS",
    month = "Oct",
    school = "London",
    title = "BBC News (Live TV)",
    year = "2012",
    confidential = "False",
    day = "30",
    publicationstatus = "published",
    }

  • Baum, M., Vaidya, J., Bulsara, M., Wenz, F., Tobias, J., Eiermann, W. & Joseph, D. (2012) INSIGHTS INTO THE NATURAL HISTORY OF SUBCLINICAL BREAST CANCER: A BIOLOGICAL FALL OUT FROM THE TARGIT-A TRIAL. IN Annals of Oncology, 23.ixe 1–ixe 30. doi:10.1093/annonc/mds499
    [BibTeX] [Abstract] [Download PDF]

    Introduction The TARGIT-A trial (n = 3451) has completed recruitment and the fresh analysis confirms that the risk-adjusted approach using targeted intra-operative radiotherapy (TARGIT) achieves local control that is non-inferior to conventional whole breast radiotherapy (EBRT). Method Patients could be randomised and receive TARGIT either at the time of the lumpectomy (pre-pathology stratum), or afterwards as a second procedure (post-pathology stratum). In the pre-pathology stratum, if protocol-defined adverse pathological features were found post operatively, the whole breast was irradiated (avoiding boost) in addition to intra-operative radiotherapy. This analysis looks at the pattern of local recurrence (LR) in the pre-pathology stratum, 64% of whom were screen detected. Results The 5-year KM estimate of local recurrence outside the index quadrants was similar in the two randomised groups (TARGIT: 0.8% vs. EBRT 0.4

    @article{baum2012insightstrial,
    author = "Baum, M and Vaidya, JS and Bulsara, M and Wenz, F and Tobias, JS and Eiermann, W and Joseph, D",
    journal = "Annals of Oncology",
    month = "Sep",
    number = "LBA10",
    pages = "ixe 1--ixe 30",
    title = "INSIGHTS INTO THE NATURAL HISTORY OF SUBCLINICAL BREAST CANCER: A BIOLOGICAL FALL OUT FROM THE TARGIT-A TRIAL",
    url = "http://annonc.oxfordjournals.org/content/23/suppl_9/ixe1.full?sid=fe8dd547-589b-4a56-a02b-c8ba24649a6a",
    volume = "23",
    year = "2012",
    abstract = "Introduction The TARGIT-A trial (n = 3451) has completed recruitment and the fresh analysis confirms that the risk-adjusted approach using targeted intra-operative radiotherapy (TARGIT) achieves local control that is non-inferior to conventional whole breast radiotherapy (EBRT).
    Method Patients could be randomised and receive TARGIT either at the time of the lumpectomy (pre-pathology stratum), or afterwards as a second procedure (post-pathology stratum). In the pre-pathology stratum, if protocol-defined adverse pathological features were found post operatively, the whole breast was irradiated (avoiding boost) in addition to intra-operative radiotherapy. This analysis looks at the pattern of local recurrence (LR) in the pre-pathology stratum, 64% of whom were screen detected.
    Results The 5-year KM estimate of local recurrence outside the index quadrants was similar in the two randomised groups (TARGIT: 0.8% vs. EBRT 0.4%, p = 0.709). Subsequently we were able to derive a group of 498 patients who received no treatment to the ipsilateral breast beyond the index quadrant, only 2 of whom experienced a LR that was outside the index quadrant. If we assume that approximately 60% of these patients had occult disease outside the index quadrant [1], then we have 296 women with locally untreated occult foci of breast cancer that failed to progress following1923 woman-years exposure to risk.
    Conclusion These data illustrate the danger of over-diagnosis and overtreatment of subclinical breast cancer and together add further fuel to the debate on the harms versus benefits of mammographic screening.
    References: 1. Vaidya JS, Vyas JJ, Chinoy RF, Merchant N, Sharma OP, Mittra I. Multicentricity of breast cancer: whole-organ analysis and clinical implications. Br J Cancer 1996;74(5):820-4.",
    doi = "10.1093/annonc/mds499",
    issue = "Suppl. 9",
    day = "28",
    publicationstatus = "published",
    }

  • Retsky, M., Demicheli, R., Hrushesky, W., Forget, P., De Kock, M., Gukas, I., Rogers, R., Baum, M., Pachmann, K. & Vaidya, J. (2012) Promising development from translational or perhaps anti-translational research in breast cancer. IN Clinical and Translational Medicine, 1.. doi:10.1186/2001-1326-1-17
    [BibTeX] [Abstract] [Download PDF]

    Background A great deal of the public’s money has been spent on cancer research but demonstrable benefits to patients have not been proportionate. We are a group of scientists and physicians who several decades ago were confronted with bimodal relapse patterns among early stage breast cancer patients who were treated by mastectomy. Since the bimodal pattern was not explainable with the then well-accepted continuous growth model, we proposed that metastatic disease was mostly inactive before surgery but was driven into growth somehow by surgery. Most relapses in breast cancer would fall into the surgery-induced growth category thus it was highly important to understand the ramifications of this process and how it may be curtailed. With this hypothesis, we have been able to explain a wide variety of clinical observations including why mammography is less effective for women age 40–49 than it is for women age 50–59, why adjuvant chemotherapy is most effective for premenopausal women with positive lymph nodes, and why there is a racial disparity in outcome. Methods We have been diligently looking for new clinical or laboratory information that could provide a connection or correlation between the bimodal relapse pattern and some clinical factor or interventional action and perhaps lead us towards methods to prevent surgery-initiated tumor activity. Results A recent development occurred when a retrospective study appeared in an anesthesiology journal that suggested the perioperative NSAID analgesic ketorolac seems to reduce early relapses following mastectomy. Collaborating with these anesthesiologists to understand this effect, we independently re-examined and updated their data and, in search of a mechanism, focused in on the transient systemic inflammation that follows surgery to remove a primary tumor. We have arrived at several possible explanations ranging from mechanical to biological that suggest the relapses avoided in the early years do not show up later. Conclusions We present the possibility that a nontoxic and low cost intervention could prevent early relapses. It may be that preventing systemic inflammation post surgery will prevent early relapses. This could be controlled by the surgical anesthesiologist’s choice of analgesic drugs. This development needs to be confirmed in a randomized controlled clinical trial and we have identified triple negative breast cancer as the ideal subset with which to test this. If successful, this would be relatively easy to implement in developing as well as developed countries and would be an important translational result.

    @article{retsky2012promisingcancer,
    author = "Retsky, M and Demicheli, R and Hrushesky, WJM and Forget, P and De Kock, M and Gukas, I and Rogers, RA and Baum, M and Pachmann, K and Vaidya, JS",
    journal = "Clinical and Translational Medicine",
    month = "Aug",
    publisher = "Springer",
    title = "Promising development from translational or perhaps anti-translational research in breast cancer",
    url = "http://www.clintransmed.com/content/1/1/17",
    volume = "1",
    year = "2012",
    abstract = "Background
    A great deal of the public's money has been spent on cancer research but demonstrable benefits to patients have not been proportionate. We are a group of scientists and physicians who several decades ago were confronted with bimodal relapse patterns among early stage breast cancer patients who were treated by mastectomy. Since the bimodal pattern was not explainable with the then well-accepted continuous growth model, we proposed that metastatic disease was mostly inactive before surgery but was driven into growth somehow by surgery. Most relapses in breast cancer would fall into the surgery-induced growth category thus it was highly important to understand the ramifications of this process and how it may be curtailed. With this hypothesis, we have been able to explain a wide variety of clinical observations including why mammography is less effective for women age 40--49 than it is for women age 50--59, why adjuvant chemotherapy is most effective for premenopausal women with positive lymph nodes, and why there is a racial disparity in outcome.
    Methods
    We have been diligently looking for new clinical or laboratory information that could provide a connection or correlation between the bimodal relapse pattern and some clinical factor or interventional action and perhaps lead us towards methods to prevent surgery-initiated tumor activity.
    Results
    A recent development occurred when a retrospective study appeared in an anesthesiology journal that suggested the perioperative NSAID analgesic ketorolac seems to reduce early relapses following mastectomy. Collaborating with these anesthesiologists to understand this effect, we independently re-examined and updated their data and, in search of a mechanism, focused in on the transient systemic inflammation that follows surgery to remove a primary tumor. We have arrived at several possible explanations ranging from mechanical to biological that suggest the relapses avoided in the early years do not show up later.
    Conclusions
    We present the possibility that a nontoxic and low cost intervention could prevent early relapses. It may be that preventing systemic inflammation post surgery will prevent early relapses. This could be controlled by the surgical anesthesiologist's choice of analgesic drugs. This development needs to be confirmed in a randomized controlled clinical trial and we have identified triple negative breast cancer as the ideal subset with which to test this. If successful, this would be relatively easy to implement in developing as well as developed countries and would be an important translational result.",
    doi = "10.1186/2001-1326-1-17",
    day = "28",
    publicationstatus = "published",
    }

  • Retsky, M., Rogers, R., Demicheli, R., Hrushesky, W., Gukas, I., Vaidya, J., Baum, M., Forget, P., Dekock, M. & Pachmann, K. (2012) NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup.. IN Breast Cancer Res Treat, .. doi:10.1007/s10549-012-2094-5
    [BibTeX] [Abstract]

    To explain a bimodal relapse hazard among early stage breast cancer patients treated by mastectomy we postulated that relapses within 4 years of surgery resulted from something that happened at about the time of surgery to provoke sudden exits from dormant phases to active growth. Relapses at 10 months appeared to be surgery-induced angiogenesis of dormant avascular micrometastases. Another relapse mode with peak about 30 months corresponded to sudden growth from a single cell. Late relapses were not synchronized to surgery. This hypothesis could explain a wide variety of breast cancer observations. We have been looking for new data that might provide more insight concerning the various relapse modes. Retrospective data reported in June 2010 study of 327 consecutive patients compared various perioperative analgesics and anesthetics in one Belgian hospital and one surgeon. Patients were treated with mastectomy and conventional adjuvant therapy. Follow-up was average 27.3 months with range 13-44 months. Updated hazard as of September 2011 for this series is now presented. NSAID ketorolac, a common analgesic used in surgery, is associated with far superior disease-free survival in the first few years after surgery. The expected prominent early relapse events are all but absent. In the 9-18 month period, there is fivefold reduction in relapses. If this observation holds up to further scrutiny, it could mean that the simple use of this safe and effective anti-inflammatory agent at surgery might eliminate most early relapses. Transient systemic inflammation accompanying surgery could be part of the metastatic tumor seeding process and could have been effectively blocked by perioperative anti-inflammatory agents. In addition, antiangiogenic properties of NSAIDs could also play a role. Triple negative breast cancer may be the ideal group with which to test perioperative ketorolac to prevent early relapses.

    @article{retsky2012nsaidsubgroup.,
    address = "Harvard School of Public Health, BLDG I, Rm 1311, 665 Huntington, Ave, Boston, MA, 02115, USA, michael.retsky@gmail.com.",
    author = "Retsky, M and Rogers, R and Demicheli, R and Hrushesky, WJ and Gukas, I and Vaidya, JS and Baum, M and Forget, P and Dekock, M and Pachmann, K",
    journal = "Breast Cancer Res Treat",
    month = "May",
    title = "NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: particular relevance to triple negative subgroup.",
    year = "2012",
    abstract = "To explain a bimodal relapse hazard among early stage breast cancer patients treated by mastectomy we postulated that relapses within 4 years of surgery resulted from something that happened at about the time of surgery to provoke sudden exits from dormant phases to active growth. Relapses at 10 months appeared to be surgery-induced angiogenesis of dormant avascular micrometastases. Another relapse mode with peak about 30 months corresponded to sudden growth from a single cell. Late relapses were not synchronized to surgery. This hypothesis could explain a wide variety of breast cancer observations. We have been looking for new data that might provide more insight concerning the various relapse modes. Retrospective data reported in June 2010 study of 327 consecutive patients compared various perioperative analgesics and anesthetics in one Belgian hospital and one surgeon. Patients were treated with mastectomy and conventional adjuvant therapy. Follow-up was average 27.3 months with range 13-44 months. Updated hazard as of September 2011 for this series is now presented. NSAID ketorolac, a common analgesic used in surgery, is associated with far superior disease-free survival in the first few years after surgery. The expected prominent early relapse events are all but absent. In the 9-18 month period, there is fivefold reduction in relapses. If this observation holds up to further scrutiny, it could mean that the simple use of this safe and effective anti-inflammatory agent at surgery might eliminate most early relapses. Transient systemic inflammation accompanying surgery could be part of the metastatic tumor seeding process and could have been effectively blocked by perioperative anti-inflammatory agents. In addition, antiangiogenic properties of NSAIDs could also play a role. Triple negative breast cancer may be the ideal group with which to test perioperative ketorolac to prevent early relapses.",
    doi = "10.1007/s10549-012-2094-5",
    eissn = "1573-7217",
    language = "ENG",
    day = "24",
    publicationstatus = "published",
    }

  • Vaidya, J. & Baum, M. (2012) TARGIT .
    [BibTeX]
    @misc{vaidya2012targittargit,
    author = "Vaidya, JS and Baum, M",
    howpublished = "iOS for iPhone, iPod touch and iPad",
    month = "Feb",
    school = "iTunes",
    title = "TARGIT",
    year = "2012",
    day = "12",
    publicationstatus = "published",
    }

  • Retsky, M., Rogers, R., Demicheli, R., Hrushesky, W., Gukas, I., Vaidya, J., Baum, M., Forget, P., DeKock, M. & Pachmann, K. (2011) NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: something for nothing in breast cancer. IN Cancer Research, 71.P2-01-06. doi:10.1158/0008-5472.SABCS11-P2-01-06
    [BibTeX] [Abstract] [Download PDF]

    Background: Over a decade ago, we were confronted with data that showed an unexpected bimodal pattern of hazard of relapse among early stage breast cancer patients treated by mastectomy without any adjuvant systemic treatment. This pattern has now been identified in 20 independent databases from US, Europe and Asia. There is an early peak of relapses at 18 months, a nadir at 50 months and a broad second peak extending from 60 months to over 15 years. Fifty to eighty percent of relapses, the proportion increasing with primary tumor size, reside within the first peak. This pattern was not explainable by accepted theories. We proposed based on computer simulations that the broad second peak relapses result from steady stochastic progressions from single dormant malignant cells to avascular micrometastases and then on to growing deposits. To explain the first peak, we had to postulate that something happened at about the time of surgery to provoke sudden exits from dormant phases to active growth and then to detection. There was a particularly sharp early relapse mode within 10 months for premenopausal patients with positive nodes that appeared to be surgery-induced angiogenesis of dormant avascular micrometastases. We have been able to explain a wide variety of breast cancer observations with this hypothesis. These include high effectiveness of adjuvant chemotherapy only for premenopausal node positive women and why early detection works better for women age 50-59 than for women age 40-49. Methods and Materials: Forget et al reported data from a retrospective study of 327 consecutive patients comparing various perioperative analgesics and anesthetics in one Belgian hospital and one surgeon. Patients were treated with mastectomy and conventional adjuvant therapy. Follow-up is average 27.3 months with range 13-44 months. Results: NSAID ketorolac, a common analgesic used in surgery, produced far superior disease-free survival in the first 5 years after surgery. The expected prominent early relapse peak is all but absent. These results are superior to any adjuvant therapy we have examined. Discussion: If this observation holds up to further scrutiny, it could mean that the simple use of this safe and effective anti-inflammatory agent at surgery might eliminate early relapses. Concerning a possible mechanism, since ketorolac is the only anti-inflammatory agent among the analgesics studied, our attention is drawn to inflammation. Might this imply that transient systemic inflammation accompanying surgery is part of the metastatic tumor seeding process? Inflammation can be a very rapidly occurring effect since bump and redness following a mosquito bite occur within seconds. It is well established that many cancer patients have circulating cancer cells. Data show a surge in circulating epidermal cells after primary breast cancer surgery but that intriguingly occurs days later. Blood speed in capillaries is 0.03cm/sec which would make leaky capillary venules a very efficient way for circulating cancer cells to enter tissue. From our simulations the few relapses in the ketorolac data look like the leading edge of the late broad peak – viewable for the first time.

    @article{retsky2011nsaidcancer,
    author = "Retsky, M and Rogers, R and Demicheli, R and Hrushesky, W and Gukas, I and Vaidya, JS and Baum, M and Forget, P and DeKock, M and Pachmann, K",
    journal = "Cancer Research",
    month = "Dec",
    pages = "P2-01-06",
    publisher = "San Antonio Breast Cancer Symposium",
    school = "http://www.abstracts2view.com/sabcs11/view.php?nu=SABCS11L_277",
    title = "NSAID analgesic ketorolac used perioperatively may suppress early breast cancer relapse: something for nothing in breast cancer",
    url = "http://strittermed.org/breast_equity/wp-content/uploads/2012/01/San-Antonio-poster-11-6-11-final.pdf",
    url = "http://cancerres.aacrjournals.org/cgi/content/meeting_abstract/71/24_MeetingAbstracts/P2-01-06",
    volume = "71",
    year = "2011",
    abstract = "Background: Over a decade ago, we were confronted with data that showed an unexpected bimodal pattern of hazard of relapse among early stage breast cancer patients treated by mastectomy without any adjuvant systemic treatment. This pattern has now been identified in 20 independent databases from US, Europe and Asia. There is an early peak of relapses at 18 months, a nadir at 50 months and a broad second peak extending from 60 months to over 15 years. Fifty to eighty percent of relapses, the proportion increasing with primary tumor size, reside within the first peak. This pattern was not explainable by accepted theories. We proposed based on computer simulations that the broad second peak relapses result from steady stochastic progressions from single dormant malignant cells to avascular micrometastases and then on to growing deposits. To explain the first peak, we had to postulate that something happened at about the time of surgery to provoke sudden exits from dormant phases to active growth and then to detection. There was a particularly sharp early relapse mode within 10 months for premenopausal patients with positive nodes that appeared to be surgery-induced angiogenesis of dormant avascular micrometastases. We have been able to explain a wide variety of breast cancer observations with this hypothesis. These include high effectiveness of adjuvant chemotherapy only for premenopausal node positive women and why early detection works better for women age 50-59 than for women age 40-49.
    Methods and Materials: Forget et al reported data from a retrospective study of 327 consecutive patients comparing various perioperative analgesics and anesthetics in one Belgian hospital and one surgeon. Patients were treated with mastectomy and conventional adjuvant therapy. Follow-up is average 27.3 months with range 13-44 months.
    Results: NSAID ketorolac, a common analgesic used in surgery, produced far superior disease-free survival in the first 5 years after surgery. The expected prominent early relapse peak is all but absent. These results are superior to any adjuvant therapy we have examined.
    Discussion: If this observation holds up to further scrutiny, it could mean that the simple use of this safe and effective anti-inflammatory agent at surgery might eliminate early relapses. Concerning a possible mechanism, since ketorolac is the only anti-inflammatory agent among the analgesics studied, our attention is drawn to inflammation. Might this imply that transient systemic inflammation accompanying surgery is part of the metastatic tumor seeding process? Inflammation can be a very rapidly occurring effect since bump and redness following a mosquito bite occur within seconds. It is well established that many cancer patients have circulating cancer cells. Data show a surge in circulating epidermal cells after primary breast cancer surgery but that intriguingly occurs days later. Blood speed in capillaries is 0.03cm/sec which would make leaky capillary venules a very efficient way for circulating cancer cells to enter tissue. From our simulations the few relapses in the ketorolac data look like the leading edge of the late broad peak - viewable for the first time.",
    doi = "10.1158/0008-5472.SABCS11-P2-01-06",
    issue = "Suppl. 24",
    day = "8",
    publicationstatus = "published",
    }

  • Vaidya, J., Baum, M., Tobias, J., Wenz, F., Massarut, S., Keshtgar, M., Hilaris, B., Saunders, C., Williams, N., Brew-Graves, C., Corica, T., Roncadin, M., Kraus-Tiefenbacher, U., Sütterlin, M., Bulsara, M. & Joseph, D. (2011) Long-term Results of Targeted Intraoperative Radiotherapy (Targit) Boost during Breast-conserving Surgery.. IN Int J Radiat Oncol Biol Phys, 81.1091-1097. doi:10.1016/j.ijrobp.2010.07.1996
    [BibTeX] [Abstract]

    PURPOSE: We have previously shown that delivering targeted radiotherapy to the tumour bed intraoperatively is feasible and desirable. In this study, we report on the feasibility, safety, and long-term efficacy of TARGeted Intraoperative radioTherapy (Targit), using the Intrabeam system. METHODS AND MATERIALS: A total of 300 cancers in 299 unselected patients underwent breast-conserving surgery and Targit as a boost to the tumor bed. After lumpectomy, a single dose of 20 Gy was delivered intraoperatively. Postoperative external beam whole-breast radiotherapy excluded the usual boost. We also performed a novel individualized case control (ICC) analysis that computed the expected recurrences for the cohort by estimating the risk of recurrence for each patient using their characteristics and follow-up period. RESULTS: The treatment was well tolerated. The median follow up was 60.5 months (range, 10-122 months). Eight patients have had ipsilateral recurrence: 5-year Kaplan Meier estimate for ipsilateral recurrence is 1.73% (SE 0.77), which compares well with that seen in the boosted patients in the European Organization for Research and Treatment of Cancer study (4.3%) and the UK STAndardisation of breast RadioTherapy study (2.8%). In a novel ICC analysis of 242 of the patients, we estimated that there should be 11.4 recurrences; in this group, only 6 recurrences were observed. CONCLUSIONS: Lumpectomy and Targit boost combined with external beam radiotherapy results in a low local recurrence rate in a standard risk patient population. Accurate localization and the immediacy of the treatment that has a favorable effect on tumour microenvironment may contribute to this effect. These long-term data establish the long-term safety and efficacy of the Targit technique and generate the hypothesis that Targit boost might be superior to an external beam boost in its efficacy and justifies a randomized trial.

    @article{vaidya2011long-termsurgery.,
    author = "Vaidya, JS and Baum, M and Tobias, JS and Wenz, F and Massarut, S and Keshtgar, M and Hilaris, B and Saunders, C and Williams, NR and Brew-Graves, C and Corica, T and Roncadin, M and Kraus-Tiefenbacher, U and Sütterlin, M and Bulsara, M and Joseph, D",
    journal = "Int J Radiat Oncol Biol Phys",
    month = "Nov",
    pages = "1091--1097",
    publisher = "Elsevier",
    title = "Long-term Results of Targeted Intraoperative Radiotherapy (Targit) Boost during Breast-conserving Surgery.",
    volume = "81",
    year = "2011",
    abstract = "PURPOSE: We have previously shown that delivering targeted radiotherapy to the tumour bed intraoperatively is feasible and desirable. In this study, we report on the feasibility, safety, and long-term efficacy of TARGeted Intraoperative radioTherapy (Targit), using the Intrabeam system. METHODS AND MATERIALS: A total of 300 cancers in 299 unselected patients underwent breast-conserving surgery and Targit as a boost to the tumor bed. After lumpectomy, a single dose of 20 Gy was delivered intraoperatively. Postoperative external beam whole-breast radiotherapy excluded the usual boost. We also performed a novel individualized case control (ICC) analysis that computed the expected recurrences for the cohort by estimating the risk of recurrence for each patient using their characteristics and follow-up period. RESULTS: The treatment was well tolerated. The median follow up was 60.5 months (range, 10-122 months). Eight patients have had ipsilateral recurrence: 5-year Kaplan Meier estimate for ipsilateral recurrence is 1.73% (SE 0.77), which compares well with that seen in the boosted patients in the European Organization for Research and Treatment of Cancer study (4.3%) and the UK STAndardisation of breast RadioTherapy study (2.8%). In a novel ICC analysis of 242 of the patients, we estimated that there should be 11.4 recurrences; in this group, only 6 recurrences were observed. CONCLUSIONS: Lumpectomy and Targit boost combined with external beam radiotherapy results in a low local recurrence rate in a standard risk patient population. Accurate localization and the immediacy of the treatment that has a favorable effect on tumour microenvironment may contribute to this effect. These long-term data establish the long-term safety and efficacy of the Targit technique and generate the hypothesis that Targit boost might be superior to an external beam boost in its efficacy and justifies a randomized trial.",
    doi = "10.1016/j.ijrobp.2010.07.1996",
    issn = "1879-355X",
    issue = "4",
    language = "ENG",
    pii = "S0360-3016(10)03043-9",
    day = "15",
    publicationstatus = "published",
    }

  • Vaidya, J. (2011) Woman’s Hour BBC Radio 4 Live BBC.
    [BibTeX]
    @misc{vaidya2011womanslive,
    author = "Vaidya, JS",
    month = "Oct",
    publisher = "BBC",
    school = "London",
    title = "Woman's Hour BBC Radio 4 Live",
    year = "2011",
    confidential = "False",
    day = "27",
    publicationstatus = "published",
    }

  • Dindyal, S. & Vaidya, J. (2011) Novel use of Prolene suture for duct delineation during microductectomy. IN Surgical Techniques Development, 1.e11.
    [BibTeX]
    @article{dindyal2011novelmicroductectomy,
    author = "Dindyal, S and Vaidya, JS",
    journal = "Surgical Techniques Development",
    month = "Aug",
    pages = "e11",
    title = "Novel use of Prolene suture for duct delineation during microductectomy",
    volume = "1",
    year = "2011",
    issn = "2038-9582",
    issue = "1",
    day = "31",
    publicationstatus = "published",
    }

  • Vaidya, J. (2011) Woman’s Hour, BBC Radio 4 Live BBC.
    [BibTeX]
    @misc{vaidya2011womanslive,
    author = "Vaidya, JS",
    month = "Aug",
    publisher = "BBC",
    school = "London",
    title = "Woman's Hour, BBC Radio 4 Live",
    year = "2011",
    confidential = "False",
    keyword = "Breast Cancer",
    day = "4",
    publicationstatus = "published",
    }

  • Wenz, F., Vaidya, J., Joseph, D., Bulsara, M., Williams, N., Tobias, J. & Baum, M. (2011) TARGETED INTRAOPERATIVE RADIOTHERAPY–THE TARGIT-A TRIAL UPDATE. IN Radiotherapy and Oncology, 99.S123–S124.
    [BibTeX]
    @article{wenz2011targetedupdate,
    author = "Wenz, F and Vaidya, J and Joseph, D and Bulsara, M and Williams, N and Tobias, J and Baum, M",
    journal = "Radiotherapy and Oncology",
    month = "May",
    pages = "S123--S124",
    publisher = "Elsevier",
    title = "TARGETED INTRAOPERATIVE RADIOTHERAPY–THE TARGIT-A TRIAL UPDATE",
    volume = "99",
    year = "2011",
    issn = "0167-8140",
    issue = "311 oral",
    day = "31",
    publicationstatus = "published",
    }

  • Keshtgar, M., Vaidya, J., Tobias, J., Wenz, F., Joseph, D., Stacey, C., Metaxas, M., Keller, A., Corica, T., Williams, N. & Baum, M. (2011) Targeted intraoperative radiotherapy for breast cancer in patients in whom external beam radiation is not possible.. IN Int J Radiat Oncol Biol Phys, 80.31-38. doi:10.1016/j.ijrobp.2010.01.045
    [BibTeX] [Abstract] [Download PDF]

    External beam radiation therapy (EBRT) following wide local excision of the primary tumor is the standard treatment in early breast cancer. In some circumstances this procedure is not possible or is contraindicated or difficult. The purpose of this study was to determine the safety and efficacy of targeted intraoperative radiotherapy (TARGIT) when EBRT is not feasible.

    @article{keshtgar2011targetedpossible.,
    author = "Keshtgar, MR and Vaidya, JS and Tobias, JS and Wenz, F and Joseph, D and Stacey, C and Metaxas, MG and Keller, A and Corica, T and Williams, NR and Baum, M",
    journal = "Int J Radiat Oncol Biol Phys",
    month = "May",
    organization = "United States",
    pages = "31--38",
    title = "Targeted intraoperative radiotherapy for breast cancer in patients in whom external beam radiation is not possible.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/20646864",
    volume = "80",
    year = "2011",
    abstract = "External beam radiation therapy (EBRT) following wide local excision of the primary tumor is the standard treatment in early breast cancer. In some circumstances this procedure is not possible or is contraindicated or difficult. The purpose of this study was to determine the safety and efficacy of targeted intraoperative radiotherapy (TARGIT) when EBRT is not feasible.",
    doi = "10.1016/j.ijrobp.2010.01.045",
    eissn = "1879-355X",
    issue = "1",
    keyword = "Adult",
    keyword = "Aged",
    keyword = "Aged, 80 and over",
    keyword = "Australia",
    keyword = "Breast Neoplasms",
    keyword = "Female",
    keyword = "Follow-Up Studies",
    keyword = "Germany",
    keyword = "Great Britain",
    keyword = "Humans",
    keyword = "Intraoperative Period",
    keyword = "Middle Aged",
    keyword = "Neoplasm Recurrence, Local",
    keyword = "Radiotherapy",
    keyword = "Tumor Burden",
    language = "eng",
    pii = "S0360-3016(10)00145-8",
    day = "1",
    }

  • Kraus-Tiefenbacher, U., Biggs, P., Vaidya, J. & Francescatti, D. (2011) Electronic Brachytherapy / Low KV IORT: Physics and Techniques. IN Gunderson, L., Willett, C., Calvo, F. & Harrison, L. (Eds.), Intraoperative Irradiation: Techniques and Results.. doi:10.1007/978-1-61779-015-7
    [BibTeX]
    @incollection{kraus-tiefenbacher2011electronictechniques,
    author = "Kraus-Tiefenbacher, U and Biggs, P and Vaidya, JS and Francescatti, D",
    booktitle = "Intraoperative Irradiation: Techniques and Results",
    editor = "Gunderson, LL and Willett, CG and Calvo, FA and Harrison, LB",
    month = "Apr",
    number = "5",
    pages = "89--98",
    publisher = "Springer",
    school = "New York Dordrecht Heidelberg London",
    title = "Electronic Brachytherapy / Low KV IORT: Physics and Techniques",
    year = "2011",
    doi = "10.1007/978-1-61779-015-7",
    isbn = "1617790141",
    isbn = "9781617790140",
    keyword = "TARGIT",
    keyword = "Breast cancer",
    keyword = "intraoperative radiotherapy",
    keyword = "IORT",
    language = "English",
    day = "15",
    publicationstatus = "published",
    }

  • Thorat, M., Thorat, P., Vaidya, H. & JS, V. (2011) Analysis of temporal trends in the BMJ archive. IN BMJ: British Medical Journal, 341.c3306. doi:10.1136/bmj.c3306
    [BibTeX] [Download PDF]
    @article{thorat2011analysisarchive,
    author = "Thorat, MA and Thorat, PM and Vaidya, HJ and Vaidya JS",
    journal = "BMJ: British Medical Journal",
    month = "Feb",
    pages = "c3306",
    title = "Analysis of temporal trends in the BMJ archive",
    url = "http://www.bmj.com/content/341/bmj.c3306",
    volume = "341",
    year = "2011",
    doi = "10.1136/bmj.c3306",
    day = "5",
    publicationstatus = "published",
    }

  • Thorat, M., Thorat, P., Vaidya, H. & Vaidya, J. (2011) 169 years of medical research: An analysis of the temporal trends in the BMJ Archive. IN BMJ (Clinical Research Ed.), 342.329.
    [BibTeX] [Download PDF]
    @article{thorat2011169archive,
    author = "Thorat, M and Thorat, P and Vaidya, H and Vaidya, JS",
    journal = "BMJ (Clinical Research Ed.)",
    month = "Feb",
    pages = "329",
    title = "169 years of medical research: An analysis of the temporal trends in the BMJ Archive",
    url = "http://www.bmj.com/content/341/bmj.c3306",
    volume = "342",
    year = "2011",
    issn = "0959-8138",
    publicationstatus = "published",
    }

  • Bertaud, S., Dindyal, S., Kaur, C. & Vaidya, J. (2011) Diffuse primary large B cell lymphoma of leg type presenting on the breast: a rare case of surgical excision. IN BMJ Case Reports, .. doi:10.1136/bcr.05.2011.4286
    [BibTeX] [Abstract]

    Primary breast lymphoma is a rare subtype of breast malignancy whose diagnosis relies on histopathological characteristics and a high index of suspicion in clinically unusual presentations of breast pathology. The authors report a rare case of diffuse primary large B cell lymphoma of leg type presenting as a single lesion confined to the breast. Unusually for this subtype of lymphoma, the lesion was surgically excised and the patient, to date, has made an uneventful recovery.

    @article{bertaud2011diffuseexcision,
    author = "Bertaud, S and Dindyal, S and Kaur, C and Vaidya, JS",
    journal = "BMJ Case Reports",
    title = "Diffuse primary large B cell lymphoma of leg type presenting on the breast: a rare case of surgical excision",
    year = "2011",
    abstract = "Primary breast lymphoma is a rare subtype of breast malignancy whose diagnosis relies on histopathological characteristics and a high index of suspicion in clinically unusual presentations of breast pathology. The authors report a rare case of diffuse primary large B cell lymphoma of leg type presenting as a single lesion confined to the breast. Unusually for this subtype of lymphoma, the lesion was surgically excised and the patient, to date, has made an uneventful recovery.",
    doi = "10.1136/bcr.05.2011.4286",
    publicationstatus = "published",
    }

  • Bertaud, S., Dindyal, S., Kaur, C. & Vaidya, J. (2011) Diffuse primary large B cell lymphoma of leg type presenting on the breast: a rare case of surgical excision.. IN BMJ case reports, 2011..
    [BibTeX] [Abstract]

    Primary breast lymphoma is a rare subtype of breast malignancy whose diagnosis relies on histopathological characteristics and a high index of suspicion in clinically unusual presentations of breast pathology. The authors report a rare case of diffuse primary large B cell lymphoma of leg type presenting as a single lesion confined to the breast. Unusually for this subtype of lymphoma, the lesion was surgically excised and the patient, to date, has made an uneventful recovery.

    @article{bertaud2011diffuseexcision.,
    author = "Bertaud, S and Dindyal, S and Kaur, C and Vaidya, J",
    journal = "BMJ case reports",
    title = "Diffuse primary large B cell lymphoma of leg type presenting on the breast: a rare case of surgical excision.",
    volume = "2011",
    year = "2011",
    abstract = "Primary breast lymphoma is a rare subtype of breast malignancy whose diagnosis relies on histopathological characteristics and a high index of suspicion in clinically unusual presentations of breast pathology. The authors report a rare case of diffuse primary large B cell lymphoma of leg type presenting as a single lesion confined to the breast. Unusually for this subtype of lymphoma, the lesion was surgically excised and the patient, to date, has made an uneventful recovery.",
    eissn = "1757-790X",
    }

  • Wenz, F., Kraus-Tiefenbacher, U., Vaidya, J. & Baum, M. (2011) Intraoperative Radiotherapy for Breast Cancer Wenz, F. & Kraus-Tiefenbacher, U. (Eds.), .
    [BibTeX]
    @book{wenz2011intraoperativecancer,
    author = "Wenz, F and Kraus-Tiefenbacher, U and Vaidya, JS and Baum, M",
    editor = "Wenz, F and Kraus-Tiefenbacher, U",
    publisher = "",
    school = "Bremen; London; Boston, Mass.",
    series = "UNI-MED Science",
    title = "Intraoperative Radiotherapy for Breast Cancer",
    year = "2011",
    isbn = "3837411788",
    isbn = "9783837411782",
    keyword = "TARGIT",
    keyword = "IORT",
    keyword = "Breast Cancer",
    publicationstatus = "published",
    }

  • Vaidya, J. (2010) Intraoperative radiotherapy for early breast cancer Reply. IN LANCET, 376.1143-1144.
    [BibTeX]
    @article{vaidya2010intraoperativereply,
    address = "UCL, London N19 5LW, England",
    author = "Vaidya, JS",
    journal = "LANCET",
    month = "Oct",
    pages = "1143--1144",
    publisher = "ELSEVIER SCIENCE INC",
    title = "Intraoperative radiotherapy for early breast cancer Reply",
    volume = "376",
    year = "2010",
    issn = "0140-6736",
    issue = "9747",
    language = "EN",
    day = "2",
    }

  • Vaidya, J. (2010) The solution to the debate (and equipoise) will come from a randomised trial. IN BMJ: British Medical Journal, ..
    [BibTeX] [Download PDF]
    @article{vaidya2010thetrial,
    author = "Vaidya, JS",
    journal = "BMJ: British Medical Journal",
    month = "Oct",
    title = "The solution to the debate (and equipoise) will come from a randomised trial",
    url = "http://www.bmj.com/rapid-response/2011/11/03/solution-debate-and-equipoise-will-come-randomised-trial",
    year = "2010",
    day = "30",
    publicationstatus = "published",
    }

  • Baum, M., Vaidya, J., Tobias, J., Keshtgar, M., Williams, N., Wenz, F., Bulsara, M., Saunders, C., Joseph, D. & Grp, T. T. (2010) TARGIT (TARGETED INTRA-OPERATIVE RADIOTHERAPY FOR EARLY STAGE BREAST CANCER): RESULTS FROM THE TARGIT A RANDOMIZED CONTROLLED TRIAL PERGAMON-ELSEVIER SCIENCE LTD, 19-19. doi:10.1016/j.ejcsup.2010.06.051
    [BibTeX]
    @inproceedings{baum2010targittrial,
    author = "Baum, M and Vaidya, JS and Tobias, JS and Keshtgar, M and Williams, NR and Wenz, F and Bulsara, M and Saunders, C and Joseph, D and TARGIT Trialists Grp",
    booktitle = "EJC SUPPLEMENTS",
    month = "Sep",
    note = "Presented as a plenary lecture by JS Vaidya",
    organization = "Nottingham, ENGLAND",
    pages = "19--19",
    publisher = "PERGAMON-ELSEVIER SCIENCE LTD",
    title = "TARGIT (TARGETED INTRA-OPERATIVE RADIOTHERAPY FOR EARLY STAGE BREAST CANCER): RESULTS FROM THE TARGIT A RANDOMIZED CONTROLLED TRIAL",
    volume = "8",
    year = "2010",
    doi = "10.1016/j.ejcsup.2010.06.051",
    startyear = "2010",
    startmonth = "Sep",
    startday = "15",
    finishyear = "2010",
    finishmonth = "Sep",
    finishday = "17",
    issn = "1359-6349",
    issue = "6",
    language = "EN",
    conference = "1st British Breast Cancer Research Conference",
    }

  • Vaidya, J. (2010) eCancerTV interview on TARGIT-A trial eCancerTV (Oncology News Channel).
    [BibTeX] [Download PDF]
    @misc{vaidya2010ecancertvtrial,
    author = "Vaidya, JS",
    month = "Sep",
    publisher = "eCancerTV (Oncology News Channel)",
    school = "ESSO meeting, Bordeaux, France",
    title = "eCancerTV interview on TARGIT-A trial",
    url = "http://ecancer.org/tv/pubdate/637",
    url = "http://ecancer.org/tv/pubdate/637",
    year = "2010",
    confidential = "False",
    day = "16",
    publicationstatus = "published",
    }

  • Baum, M., Vaidya, J., Tobias, J., Keshtgar, M., Williams, N., Wenz, F., Bulsara, M., Saunders, C. & Joseph, D. (2010) TARGIT (targeted intra-operative radiotherapy for early stage breast cancer): Results from the TARGIT a randomized controlled trial. IN European Journal of Cancer Supplements, 8.19–O-50. doi:10.1016/j.ejcsup.2010.06.051
    [BibTeX] [Abstract] [Download PDF]

    Background: After breast conserving surgery, 90% of recurrent cancer occurs within the index quadrant. Hence, restricting radiation therapy to the immediate area around the tumour bed after removal of the primary tumour may be adequate (Vaidya JS et al. Br J Cancer 1996;74:820–4). Materials and methods: Using the technique of partial breast irradiation developed at UCL (Vaidya JS, Baum M, Tobias JS, et al. Ann Oncol 2001;12:1075–80) we launched the international TARGIT A randomized controlled trial in March 2000 comparing the policies of TARGIT versus standard whole breast external beam radiotherapy (EBRT) after breast conserving surgery with local recurrence as the main outcome measure (www.thelancet.com/protocol-reviews/99PRT-47). Accrual from 28 international centers reached 2232 in April 2010, with 80% power to detect a difference in relapse rate of 2.5% (the non-inferiority margin). Results: Patient demographic and tumour characteristics are as follows: mean age 63 years (IQR 57–69), mean tumour size 12mm (IQR 9–18mm), N stage 17% +ve. We intend to present the unblinded data with an analysis of safety and efficacy. Conclusions: If this analysis shows non-inferiority, then a clinically significant difference in early local recurrence between TARGIT and EBRT remains unlikely, making single session partial breast irradiation with TARGIT a plausible new standard of care in the near future.

    @article{baum2010targittrial,
    author = "Baum, M and Vaidya, JS and Tobias, JS and Keshtgar, M and Williams, NR and Wenz, F and Bulsara, M and Saunders, C and Joseph, D",
    journal = "European Journal of Cancer Supplements",
    month = "Sep",
    pages = "19--O-50",
    publisher = "Elsevier",
    title = "TARGIT (targeted intra-operative radiotherapy for early stage breast cancer): Results from the TARGIT a randomized controlled trial",
    url = "http://www.ejcancersupplements.info/article/S1359-6349(10)00103-5/fulltext",
    volume = "8",
    year = "2010",
    abstract = "Background: After breast conserving surgery, 90% of recurrent cancer occurs within the index quadrant. Hence, restricting radiation therapy to the immediate area around the tumour bed after removal of the primary tumour may be adequate (Vaidya JS et al. Br J Cancer 1996;74:820–4).
    Materials and methods: Using the technique of partial breast irradiation developed at UCL (Vaidya JS, Baum M, Tobias JS, et al. Ann Oncol 2001;12:1075–80) we launched the international TARGIT A randomized controlled trial in March 2000 comparing the policies of TARGIT versus standard whole breast external beam radiotherapy (EBRT) after breast conserving surgery with local recurrence as the main outcome measure (www.thelancet.com/protocol-reviews/99PRT-47). Accrual from 28 international centers reached 2232 in April 2010, with 80% power to detect a difference in relapse rate of 2.5% (the non-inferiority margin).
    Results: Patient demographic and tumour characteristics are as follows: mean age 63 years (IQR 57–69), mean tumour size 12mm (IQR 9–18mm), N stage 17% +ve. We intend to present the unblinded data with an analysis of safety and efficacy.
    Conclusions: If this analysis shows non-inferiority, then a clinically significant difference in early local recurrence between TARGIT and EBRT remains unlikely, making single session partial breast irradiation with TARGIT a plausible new standard of care in the near future.",
    doi = "10.1016/j.ejcsup.2010.06.051",
    issn = "1359-6349",
    issue = "6",
    day = "30",
    }

  • Vaidya, J., Tobias, J., Baum, M., Keshtgar, M., Williams, N., Wenz, F. & Joseph, D. (2010) Response to Ïntraoperative radiotherapy in early-stage breast cancer: results of the Montpellier phase II trial.\"(Int J Radiat Oncol Biol Phys May 2009).. IN Int J Radiat Oncol Biol Phys, 77.1289. doi:10.1016/j.ijrobp.2009.09.082
    [BibTeX] [Download PDF]
    @article{vaidya2010response2009.,
    author = "Vaidya, JS and Tobias, JS and Baum, M and Keshtgar, M and Williams, N and Wenz, F and Joseph, D",
    journal = "Int J Radiat Oncol Biol Phys",
    month = "Jul",
    organization = "United States",
    pages = "1289",
    title = "Response to \"Intraoperative radiotherapy in early-stage breast cancer: results of the Montpellier phase II trial.\"(Int J Radiat Oncol Biol Phys May 2009).",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/20610047",
    volume = "77",
    year = "2010",
    doi = "10.1016/j.ijrobp.2009.09.082",
    eissn = "1879-355X",
    issue = "4",
    keyword = "Aged",
    keyword = "Aged, 80 and over",
    keyword = "Breast Neoplasms",
    keyword = "Carcinoma, Ductal, Breast",
    keyword = "Clinical Trials, Phase II as Topic",
    keyword = "Female",
    keyword = "Humans",
    keyword = "Intraoperative Period",
    keyword = "Publishing",
    language = "eng",
    pii = "S0360-3016(09)03586-X",
    day = "15",
    }

  • Vaidya, J., Joseph, D. & Tobias, J. (2010) Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial (vol 376, pg 91, 2010). IN LANCET, 376.90-90.
    [BibTeX]
    @article{vaidya2010targeted2010,
    author = "Vaidya, JS and Joseph, DJ and Tobias, JS",
    journal = "LANCET",
    month = "Jul",
    pages = "90--90",
    publisher = "ELSEVIER SCIENCE INC",
    title = "Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial (vol 376, pg 91, 2010)",
    volume = "376",
    year = "2010",
    issn = "0140-6736",
    issue = "9735",
    keyword = "ENERGY X-RAYS",
    keyword = "RADIATION-THERAPY",
    keyword = "CONSERVING SURGERY",
    keyword = "CONSERVATIVE SURGERY",
    keyword = "AXILLARY DISSECTION",
    keyword = "TUMOR RECURRENCE",
    keyword = "LOCAL RECURRENCE",
    keyword = "CLINICAL-TRIAL",
    keyword = "IRRADIATION",
    keyword = "LUMPECTOMY",
    language = "EN",
    day = "10",
    }

  • Vaidya, J., Joseph, D., Tobias, J., Bulsara, M., Wenz, F., Saunders, C., Alvarado, M., Flyger, H., Massarut, S., Eiermann, W., Keshtgar, M., Dewar, J., Kraus-Tiefenbacher, U., Sütterlin, M., Esserman, L., Holtveg, H., Roncadin, M., Pigorsch, S., Metaxas, M., Falzon, M., Matthews, A., Corica, T., Williams, N. & Baum, M. (2010) Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial.. IN Lancet, 376.91-102. doi:10.1016/S0140-6736(10)60837-9
    [BibTeX] [Abstract] [Download PDF]

    After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.

    @article{vaidya2010targetedtrial.,
    author = "Vaidya, JS and Joseph, DJ and Tobias, JS and Bulsara, M and Wenz, F and Saunders, C and Alvarado, M and Flyger, HL and Massarut, S and Eiermann, W and Keshtgar, M and Dewar, J and Kraus-Tiefenbacher, U and Sütterlin, M and Esserman, L and Holtveg, HM and Roncadin, M and Pigorsch, S and Metaxas, M and Falzon, M and Matthews, A and Corica, T and Williams, NR and Baum, M",
    journal = "Lancet",
    month = "Jul",
    organization = "England",
    pages = "91--102",
    title = "Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/20570343",
    volume = "376",
    year = "2010",
    abstract = "After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radiotherapy.",
    doi = "10.1016/S0140-6736(10)60837-9",
    eissn = "1474-547X",
    issue = "9735",
    keyword = "Aged",
    keyword = "Breast Neoplasms",
    keyword = "Carcinoma, Ductal, Breast",
    keyword = "Disease-Free Survival",
    keyword = "Female",
    keyword = "Humans",
    keyword = "Intraoperative Care",
    keyword = "Mastectomy, Segmental",
    keyword = "Middle Aged",
    keyword = "Neoplasm Recurrence, Local",
    keyword = "Radiotherapy Dosage",
    keyword = "Radiotherapy, Adjuvant",
    language = "eng",
    pii = "S0140-6736(10)60837-9",
    day = "10",
    }

  • Vaidya, J. (2010) CNN Live: Now ‘improved’ treatment for breast cancer .
    [BibTeX] [Download PDF]
    @misc{vaidya2010cnncancer,
    author = "Vaidya, JS",
    month = "Jun",
    organization = "London",
    school = "London",
    title = "CNN Live: Now 'improved' treatment for breast cancer",
    url = "http://ibnlive.in.com/news/now-improved-treatment-for-breast-cancer/124974-17.html",
    url = "http://ibnlive.in.com/news/now-improved-treatment-for-breast-cancer/124974-17.html",
    year = "2010",
    confidential = "False",
    keyword = "Breast Cancer",
    keyword = "TARGIT",
    keyword = "Targeted intraoperative radiotherapy",
    day = "21",
    publicationstatus = "published",
    }

  • Vaidya, J., Joseph, D. & Jones, A. (2010) Fast facts: breast cancer Health Press.
    [BibTeX]
    @book{vaidya2010fastcancer,
    author = "Vaidya, JS and Joseph, D and Jones, A",
    edition = "4th",
    month = "Jun",
    publisher = "Health Press",
    school = "United Kingdom",
    title = "Fast facts: breast cancer",
    year = "2010",
    isbn = "1905832788",
    isbn = "978-1905832781",
    day = "30",
    publicationstatus = "published",
    }

  • Keshtgar, M., Tobias, J., Vaidya, J., Stacey, C., Corica, T., Joseph, D., Keller, A., Wenz, F., Williams, N. & Baum, M. (2010) Single dose intra-operative radiotherapy for breast cancer patients where external beam radiation was not feasible – results after 3 years of follow-up PERGAMON-ELSEVIER SCIENCE LTD, 130-131.
    [BibTeX]
    @inproceedings{keshtgar2010singlefollow-up,
    author = "Keshtgar, M and Tobias, JS and Vaidya, JS and Stacey, C and Corica, T and Joseph, D and Keller, A and Wenz, F and Williams, NR and Baum, M",
    booktitle = "EJC SUPPLEMENTS",
    month = "Mar",
    organization = "Barcelona, SPAIN",
    pages = "130--131",
    publisher = "PERGAMON-ELSEVIER SCIENCE LTD",
    title = "Single dose intra-operative radiotherapy for breast cancer patients where external beam radiation was not feasible - results after 3 years of follow-up",
    volume = "8",
    year = "2010",
    startyear = "2010",
    startmonth = "Mar",
    startday = "24",
    finishyear = "2010",
    finishmonth = "Mar",
    finishday = "24",
    issn = "1359-6349",
    issue = "3",
    language = "EN",
    conference = "European Breast Cancer Conference",
    }

  • Vaidya, J. & Grp, T. T. (2010) Pragmatism in the TARGIT trial encouraged wider participation of centres yet yielded an unexpected homogeneous patient profile PERGAMON-ELSEVIER SCIENCE LTD, 131-131.
    [BibTeX]
    @inproceedings{vaidya2010pragmatismprofile,
    author = "Vaidya, JS and Targit Trialists's Grp",
    booktitle = "EJC SUPPLEMENTS",
    month = "Mar",
    organization = "Barcelona, SPAIN",
    pages = "131--131",
    publisher = "PERGAMON-ELSEVIER SCIENCE LTD",
    title = "Pragmatism in the TARGIT trial encouraged wider participation of centres yet yielded an unexpected homogeneous patient profile",
    volume = "8",
    year = "2010",
    startyear = "2010",
    startmonth = "Mar",
    startday = "24",
    finishyear = "2010",
    finishmonth = "Mar",
    finishday = "24",
    issn = "1359-6349",
    issue = "3",
    language = "EN",
    conference = "European Breast Cancer Conference",
    }

  • Vaidya, J. (2010) BBC News Channel – Breakfast News Live .
    [BibTeX]
    @misc{vaidya2010bbclive,
    author = "Vaidya, JS",
    month = "Mar",
    organization = "London",
    school = "London",
    title = "BBC News Channel - Breakfast News Live",
    year = "2010",
    confidential = "False",
    day = "31",
    publicationstatus = "published",
    }

  • Vaidya, J. (2010) LANDMARK CLINICAL TRIALS IN BREAST SURGICAL ONCOLOGY – The UK experience. IN Kuerer, H. (Ed.), Kuerer’s Breast Surgical Oncology. 1 ed..
    [BibTeX] [Download PDF]
    @incollection{vaidya2010landmarkexperience,
    author = "Vaidya, JS",
    booktitle = "Kuerer's Breast Surgical Oncology",
    edition = "1",
    editor = "Kuerer, H",
    howpublished = "Paper and DVD",
    number = "46",
    pages = "535--555",
    publisher = "McGraw-Hill",
    school = "United States of America",
    title = "LANDMARK CLINICAL TRIALS IN BREAST SURGICAL ONCOLOGY - The UK experience",
    url = "http://www.jayantvaidya.org/",
    url = "http://www.mhprofessional.com/product.php?isbn=0071601767",
    year = "2010",
    isbn = "0071601767",
    isbn = "978-0071601764",
    language = "English",
    publicationstatus = "published",
    }

  • Baum, M., Thornton, H., Gøtzsche, P., Bewley, S., Jørgensen, K., Barratt, A., Ross, N., Woloshin, S., Schwartz, L., Musiello, T., Blennerhassett, M., Napoli, M., Baines, C., Vaidya, J., Williams, N., Havercroft, D., Zahl, P., Retsky, M., Kaplan, R., Dixon-Woods, M., Berry, D., Isaacson, K., Brahams, D., Pryke, M., Tindall, G., Bender, D. & Marshall, T. (2010) Breast cancer awareness month. Still awaiting screening facts.. IN BMJ, 341.c6152.
    [BibTeX] [Download PDF]
    @article{baum2010breastfacts.,
    author = "Baum, M and Thornton, H and Gøtzsche, PC and Bewley, S and Jørgensen, KJ and Barratt, A and Ross, N and Woloshin, S and Schwartz, L and Musiello, T and Blennerhassett, M and Napoli, M and Baines, CJ and Vaidya, JS and Williams, N and Havercroft, D and Zahl, PH and Retsky, M and Kaplan, RM and Dixon-Woods, M and Berry, DA and Isaacson, K and Brahams, D and Pryke, M and Tindall, G and Bender, DA and Marshall, T",
    journal = "BMJ",
    organization = "England",
    pages = "c6152",
    title = "Breast cancer awareness month. Still awaiting screening facts.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/21045038",
    volume = "341",
    year = "2010",
    eissn = "1756-1833",
    keyword = "Aged",
    keyword = "Breast Neoplasms",
    keyword = "Early Detection of Cancer",
    keyword = "Female",
    keyword = "Humans",
    keyword = "Middle Aged",
    language = "eng",
    }

  • Vaidya, J., Baldassarre, G., Thorat, M. & Massarut, S. (2010) Role of glucocorticoids in breast cancer.. IN Curr Pharm Des, 16.3593-3600.
    [BibTeX] [Abstract] [Download PDF]

    Glucocorticoids play an essential role in embryonic development and tissue homeostasis and possess important anti-inflammatory and immunosuppressive properties. Due to their very wide spectrum of activity, Glucocorticoids are one of the most commonly used drugs-used in the treatment of asthma, arthritis, autoimmune diseases and shock/SIRS. glucocorticoids are a main component of treatment regimens in hematological malignancies due to their pro-apoptotic properties and are also used as co-treatment several other cancers and chemotherapy regimens including those in breast cancer treatment. In breast cancer, however, glucocorticoids may have diverse effects and could inhibit chemosensitivity. Additionally, glucocorticoids through their receptor may interact with ER in a feedback loop regulating each other’s activities. The normal variation of glucocorticoid levels with time of the day, menstrual cycle or year could have a interesting chronobiological interaction with the well recorded variation in breast cancer proliferation and metastatic potential. Glucocorticoids could play a very complex role in breast cancer epidemiology, biology and treatment; this review aims to present a comprehensive discussion as well as speculate future directions for research.

    @article{vaidya2010rolecancer.,
    author = "Vaidya, JS and Baldassarre, G and Thorat, MA and Massarut, S",
    journal = "Curr Pharm Des",
    organization = "Netherlands",
    pages = "3593--3600",
    title = "Role of glucocorticoids in breast cancer.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/20977423",
    volume = "16",
    year = "2010",
    abstract = "Glucocorticoids play an essential role in embryonic development and tissue homeostasis and possess important anti-inflammatory and immunosuppressive properties. Due to their very wide spectrum of activity, Glucocorticoids are one of the most commonly used drugs-used in the treatment of asthma, arthritis, autoimmune diseases and shock/SIRS. glucocorticoids are a main component of treatment regimens in hematological malignancies due to their pro-apoptotic properties and are also used as co-treatment several other cancers and chemotherapy regimens including those in breast cancer treatment. In breast cancer, however, glucocorticoids may have diverse effects and could inhibit chemosensitivity. Additionally, glucocorticoids through their receptor may interact with ER in a feedback loop regulating each other's activities. The normal variation of glucocorticoid levels with time of the day, menstrual cycle or year could have a interesting chronobiological interaction with the well recorded variation in breast cancer proliferation and metastatic potential. Glucocorticoids could play a very complex role in breast cancer epidemiology, biology and treatment; this review aims to present a comprehensive discussion as well as speculate future directions for research.",
    eissn = "1873-4286",
    issue = "32",
    keyword = "Breast Neoplasms",
    keyword = "Circadian Rhythm",
    keyword = "Female",
    keyword = "Glucocorticoids",
    keyword = "Humans",
    language = "eng",
    pii = "BSP/CPD/E-Pub/000244",
    }

  • Vaidya, J., Baum, M., Tobias, J., Massarut, S., Wenz, F., Hilaris, B., Corica, T., Roncadin, M., Kraus-Tiefenbacher, U., Keshtgar, M., Williams, N., Brew-Graves, C., Bulsara, M., Sanders, C. & Joseph, D. (2009) Targeted Intraoperative Radiotherapy (Targit) Boost after Breast Conserving Surgery Results in a Remarkably Low Recurrence Rate in a Standard Risk Population: 5 Year Results UCL, London, England and Ctr Riferimento Oncol, I-33081 Aviano, Italy and Univ Mannheim, Mannheim, Germany and Sir Charles Gairdner Hosp, Perth, WA, Australia and Our Lady Mercy New York Med Sch, New York, NY USA, AMER ASSOC CANCER RESEARCH, 741S–741S.
    [BibTeX]
    @inproceedings{vaidya2009targetedresults,
    address = "UCL, London, England and Ctr Riferimento Oncol, I-33081 Aviano, Italy and Univ Mannheim, Mannheim, Germany and Sir Charles Gairdner Hosp, Perth, WA, Australia and Our Lady Mercy New York Med Sch, New York, NY USA",
    author = "Vaidya, JS and Baum, M and Tobias, J and Massarut, S and Wenz, F and Hilaris, B and Corica, T and Roncadin, M and Kraus-Tiefenbacher, U and Keshtgar, M and Williams, N and Brew-Graves, C and Bulsara, M and Sanders, C and Joseph, D",
    booktitle = "CANCER RESEARCH",
    month = "Dec",
    organization = "San Antonio, TX",
    pages = "741S--741S",
    publisher = "AMER ASSOC CANCER RESEARCH",
    title = "Targeted Intraoperative Radiotherapy (Targit) Boost after Breast Conserving Surgery Results in a Remarkably Low Recurrence Rate in a Standard Risk Population: 5 Year Results",
    volume = "69",
    year = "2009",
    startyear = "2009",
    startmonth = "Dec",
    startday = "9",
    finishyear = "2009",
    finishmonth = "Dec",
    finishday = "13",
    issn = "0008-5472",
    issue = "24",
    keyword = "CANCER",
    language = "EN",
    conference = "32nd Annual San Antonio Breast Cancer Symposium",
    day = "15",
    }

  • Vaidya, J., Baum, M., Tobias, J., Massarut, S., Wenz, F., Hilaris, B., Corica, T., Roncadin, M., Kraus-Tiefenbacher, U. & Keshtgar, M. (2009) Targeted intraoperative radiotherapy (Targit) boost after breast conserving surgery results in a remarkably low recurrence rate in a standard risk population: 5 year results. IN Cancer Research, 69.4104. doi:10.1158/0008-5472.SABCS-09-4104
    [BibTeX] [Abstract]

    Background: In 1998 we started a phase II study of TARGeted Intraoperative radioTherapy (Targit) using the IntrabeamTM system. We present the updated results of this first group of breast cancer patients treated with breast conserving surgery where Targit was used as a boost to the tumour bed.Patients and Method: We treated 300 cancers in 299 patients undergoing breast-conserving surgery with no other selection criteria. 32% of the patients were younger than 51 years, 57% of cancers were between 1 to 2cm, (21% > 2cm), 29% had a grade 3 tumour and 29% were node positive. After lumpectomy, a single dose of 20Gy was delivered intraoperatively using 50 kV X-rays –calculated at the surface of the tumour bed1. In all except 9 patients Targit was delivered at the time of the lumpectomy. Postoperative external beam radiotherapy excluded the usual boost. We analyzed recurrences according to their position within the ipsilateral breast.Results: The treatment was well tolerated. The median follow up is 60.5 months (range 10-120 months). 8 patients have had ipsilateral recurrence: 5- year Kaplan Meier estimate for ipsilateral recurrence 1.74% (SE 0.77). 5 of these 8 patients had recurrence in the tumor bed: 5-year Kaplan Meier recurrence rate is 1.04% (SE 0.59). Additionally, 7 patients developed a contralateral breast cancer. Our results appear superior to those seen in the boosted patients in the EORTC study (4.3%) and the START-B study (2.8%) despite a higher node positivity in our series (29%), compared with 21% in the EORTC and 24% in the START-B trial and a larger proportion of younger women (<50 were 32% in Targit, 37% in EORTC and 21% in START-B).Conclusion: Lumpectomy and Targit boost combined with external beam radiotherapy results in an exceptionally low tumor bed recurrence rate in an unselected patient population. This could be attributed to both accurate localisation and timeliness of the treatment that could have a favorable effect on tumour micro-environment2. When used as a boost Targit is likely to be superior to conventional external boost. These data establish the long-term safety and efficacy of the Targit technique, which is being used in the soon to be completed randomised TARGIT trial of partial breast irradiation vs conventional external beam whole breast radiotherapy.1. Vaidya JS, Baum M, Tobias JS, Morgan S, D’Souza D. The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer. Eur J Surg Oncol 2002;28(4):447-54.2. Belletti B, Vaidya JS, D’Andrea S, Entschladen F, Roncadin M, Lovat F, et al. Targeted Intraoperative radiotherapy (TARGIT) impairs surgical wound-stimulated breast cancer cell proliferation and invasion Clin.Cancer Res. 2008;14(5):1325-32.

    @article{vaidya2009targetedresults,
    author = "Vaidya, JS and Baum, M and Tobias, J and Massarut, S and Wenz, F and Hilaris, B and Corica, T and Roncadin, M and Kraus-Tiefenbacher, U and Keshtgar, M",
    journal = "Cancer Research",
    month = "Dec",
    pages = "4104",
    publisher = "AMER ASSOC CANCER RESEARCH",
    title = "Targeted intraoperative radiotherapy (Targit) boost after breast conserving surgery results in a remarkably low recurrence rate in a standard risk population: 5 year results",
    volume = "69",
    year = "2009",
    abstract = "Background: In 1998 we started a phase II study of TARGeted Intraoperative radioTherapy (Targit) using the IntrabeamTM system. We present the updated results of this first group of breast cancer patients treated with breast conserving surgery where Targit was used as a boost to the tumour bed.Patients and Method: We treated 300 cancers in 299 patients undergoing breast-conserving surgery with no other selection criteria. 32% of the patients were younger than 51 years, 57% of cancers were between 1 to 2cm, (21% > 2cm), 29% had a grade 3 tumour and 29% were node positive. After lumpectomy, a single dose of 20Gy was delivered intraoperatively using 50 kV X-rays –calculated at the surface of the tumour bed1. In all except 9 patients Targit was delivered at the time of the lumpectomy. Postoperative external beam radiotherapy excluded the usual boost. We analyzed recurrences according to their position within the ipsilateral breast.Results: The treatment was well tolerated. The median follow up is 60.5 months (range 10-120 months). 8 patients have had ipsilateral recurrence: 5- year Kaplan Meier estimate for ipsilateral recurrence 1.74% (SE 0.77). 5 of these 8 patients had recurrence in the tumor bed: 5-year Kaplan Meier recurrence rate is 1.04% (SE 0.59). Additionally, 7 patients developed a contralateral breast cancer. Our results appear superior to those seen in the boosted patients in the EORTC study (4.3%) and the START-B study (2.8%) despite a higher node positivity in our series (29%), compared with 21% in the EORTC and 24% in the START-B trial and a larger proportion of younger women (<50 were 32% in Targit, 37% in EORTC and 21% in START-B).Conclusion: Lumpectomy and Targit boost combined with external beam radiotherapy results in an exceptionally low tumor bed recurrence rate in an unselected patient population. This could be attributed to both accurate localisation and timeliness of the treatment that could have a favorable effect on tumour micro-environment2. When used as a boost Targit is likely to be superior to conventional external boost. These data establish the long-term safety and efficacy of the Targit technique, which is being used in the soon to be completed randomised TARGIT trial of partial breast irradiation vs conventional external beam whole breast radiotherapy.1. Vaidya JS, Baum M, Tobias JS, Morgan S, D'Souza D. The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer. Eur J Surg Oncol 2002;28(4):447-54.2. Belletti B, Vaidya JS, D'Andrea S, Entschladen F, Roncadin M, Lovat F, et al. Targeted Intraoperative radiotherapy (TARGIT) impairs surgical wound-stimulated breast cancer cell proliferation and invasion Clin.Cancer Res. 2008;14(5):1325-32.",
    doi = "10.1158/0008-5472.SABCS-09-4104",
    issn = "0008-5472",
    issue = "Suppl. 24",
    day = "15",
    publicationstatus = "published",
    }

  • Vaidya, J., Baldassarre, G. & Massarut, S. (2009) Beneficial effects of intraoperative radiotherapy on tumor microenvironment could improve outcomes.. IN International Journal of Radiation Oncology Biology Physics, 74.976. doi:10.1016/j.ijrobp.2009.02.041
    [BibTeX]
    @article{vaidya2009beneficialoutcomes.,
    author = "Vaidya, JS and Baldassarre, G and Massarut, S",
    journal = "International Journal of Radiation Oncology Biology Physics",
    month = "Jul",
    pages = "976",
    title = "Beneficial effects of intraoperative radiotherapy on tumor microenvironment could improve outcomes.",
    volume = "74",
    year = "2009",
    doi = "10.1016/j.ijrobp.2009.02.041",
    issn = "0360-3016",
    issue = "3",
    }

  • Vaidya, J. (2009) Women undergoing screening mammography experience a higher incidence of invasive breast cancer, without a corresponding reduction in symptomatic breast cancer.. IN BMJ (Clinical Research Ed.), ..
    [BibTeX] [Download PDF]
    @article{vaidya2009womencancer.,
    author = "Vaidya, JS",
    journal = "BMJ (Clinical Research Ed.)",
    month = "Jul",
    title = "Women undergoing screening mammography experience a higher incidence of invasive breast cancer, without a corresponding reduction in symptomatic breast cancer.",
    url = "http://www.bmj.com/rapid-response/2011/11/02/women-undergoing-screening-mammography-experience-higher-incidence-invasiv",
    year = "2009",
    issn = "0959-8138",
    day = "20",
    publicationstatus = "published",
    }

  • Baum, M., Vaidya, J., Thornton, H., McCartney, M., Barrat, A. & and , 19O. (2009) Breast cancer screening peril Negative consequences of the breast screening programme. IN The Times, ..
    [BibTeX]
    @article{baum2009breastprogramme,
    author = "Baum, M and Vaidya, JS and Thornton, H and McCartney, M and Barrat, A and and, 19O",
    journal = "The Times",
    month = "Feb",
    title = "Breast cancer screening peril Negative consequences of the breast screening programme",
    year = "2009",
    day = "19",
    }

  • Keshtgar, M., Vaidya, J., Keller, A., Wenz, F., Corica, T., Joseph, D., Stacey, C., Tobias, J., Williams, N. & Baum, M. (2009) Intra-operative radiotherapy for breast cancer in patients where external beam radiation was not possible − results after 3 years of follow-up , S48.
    [BibTeX]
    @inproceedings{keshtgar2009intra-operativefollow-up,
    author = "Keshtgar, M and Vaidya, JS and Keller, A and Wenz, F and Corica, T and Joseph, D and Stacey, C and Tobias, JS and Williams, NR and Baum, M",
    booktitle = "The Breast",
    pages = "S48",
    title = "Intra-operative radiotherapy for breast cancer in patients where external beam radiation was not possible − results after 3 years of follow-up",
    volume = "18",
    year = "2009",
    issue = "Supplement 1",
    }

  • Keshtgar, M., Vaidya, J., Stacy, C., Tobias, J., Williams, N. & Baum, M. (2009) Single dose radiotherapy during surgery for breast cancer patients where external beam radiation was not feasible- results after 3 years of follow-up Department of Surgery, Royal Free Hospital, , 1239-1240.
    [BibTeX]
    @inproceedings{keshtgar2009singlefollow-up,
    address = "Department of Surgery, Royal Free Hospital",
    author = "Keshtgar, M and Vaidya, J and Stacy, C and Tobias, J and Williams, N and Baum, M",
    booktitle = "European Journal of Surgical Oncology",
    pages = "1239--1240",
    title = "Single dose radiotherapy during surgery for breast cancer patients where external beam radiation was not feasible- results after 3 years of follow-up",
    volume = "35",
    year = "2009",
    issue = "11",
    keyword = "Breast cancer",
    keyword = "radiotherapy",
    keyword = "during surgery",
    }

  • Vaidya, J. (2009) APBI with 50 Kv photons – targeted intraoperative radiotherapy (TARGIT). IN Wazer, D. (Ed.), Accelerated Partial Breast Irradiation. 2nd ed..
    [BibTeX]
    @incollection{vaidya2009apbitargit,
    author = "Vaidya, JS",
    booktitle = "Accelerated Partial Breast Irradiation",
    edition = "2nd",
    editor = "Wazer, D",
    number = "19",
    pages = "327--344",
    publisher = "Springer",
    school = "Boston",
    title = "APBI with 50 Kv photons – targeted intraoperative radiotherapy (TARGIT)",
    year = "2009",
    }

  • Hadad, S., Vaidya, J., Baker, L., Koh, H., Heron, T., Hussain, K. & Thompson, A. (2008) Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis (World Journal of Surgery 31, 6, DOI: 10.1007/s00268-007-9050-2). IN World Journal of Surgery, 32.2747-2747. doi:10.1007/s00268-008-9750-2
    [BibTeX]
    @article{hadad2008delay10.1007/s00268-007-9050-2,
    author = "Hadad, SM and Vaidya, JS and Baker, L and Koh, HC and Heron, TP and Hussain, K and Thompson, AM",
    journal = "World Journal of Surgery",
    month = "Dec",
    pages = "2747--2747",
    title = "Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis (World Journal of Surgery 31, 6, DOI: 10.1007/s00268-007-9050-2)",
    volume = "32",
    year = "2008",
    doi = "10.1007/s00268-008-9750-2",
    issn = "0364-2313",
    eissn = "1432-2323",
    issue = "12",
    }

  • Ansari, B. & Vaidya, J. (2008) Reduced adhesion formation following laparoscopic versus open colorectal surgery (Br J Surg 2008; 95: 909-914).. IN Br J Surg, 95.1542. doi:10.1002/bjs.6453
    [BibTeX] [Download PDF]
    @article{ansari2008reduced909-914.,
    author = "Ansari, B and Vaidya, JS",
    journal = "Br J Surg",
    month = "Dec",
    organization = "England",
    pages = "1542",
    title = "Reduced adhesion formation following laparoscopic versus open colorectal surgery (Br J Surg 2008; 95: 909-914).",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/18991311",
    volume = "95",
    year = "2008",
    doi = "10.1002/bjs.6453",
    eissn = "1365-2168",
    issue = "12",
    keyword = "Colorectal Neoplasms",
    keyword = "Humans",
    keyword = "Laparoscopy",
    keyword = "Tissue Adhesions",
    language = "eng",
    }

  • Vaidya, J. & Osborne, M. (2008) An uncommon (hepatic) scintiscan during sentinel node biopsy–an optical illusion.. IN Int J Surg, 6.422-423. doi:10.1016/j.ijsu.2006.05.025
    [BibTeX] [Download PDF]
    @article{vaidya2008anillusion.,
    author = "Vaidya, JS and Osborne, M",
    journal = "Int J Surg",
    month = "Oct",
    organization = "England",
    pages = "422--423",
    title = "An uncommon (hepatic) scintiscan during sentinel node biopsy--an optical illusion.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/18947817",
    volume = "6",
    year = "2008",
    doi = "10.1016/j.ijsu.2006.05.025",
    eissn = "1743-9159",
    issue = "5",
    keyword = "Aged",
    keyword = "Breast Neoplasms",
    keyword = "Diagnosis, Differential",
    keyword = "Female",
    keyword = "Humans",
    keyword = "Liver Neoplasms",
    keyword = "Lymph Nodes",
    keyword = "Neoplasm Recurrence, Local",
    keyword = "Optical Illusions",
    keyword = "Preoperative Care",
    keyword = "Reoperation",
    keyword = "Sensitivity and Specificity",
    keyword = "Sentinel Lymph Node Biopsy",
    language = "eng",
    pii = "S1743-9191(06)00132-4",
    }

  • Vaidya, J., Baum, M., Tobias, J. & et , A. (2008) Efficacy of targeted intraoperative radiotherapy (Targit) boost after breast-conserving surgery: updated results , 565.
    [BibTeX] [Abstract] [Download PDF]

    Background: In 1998 we started a phase II study of TARGeted Intraoperative radioTherapy (TARGIT) using the Intrabeam system. We present the updated results of this first group of breast cancer patients treated with breast-conserving surgery where Targit was used as a boost to the tumor bed. Methods: We treated 301 cancers in 300 patients undergoing breast- conserving surgery with no other selection criteria. 97 patients were younger than 51 years, 57% of cancers were between 1 to 2cm, (21% > 2cm), 29% had a grade 3 tumor and 29% were node positive. After lumpectomy, 20Gy was delivered intraoperatively using 50 kV X-rays to the surface of the tumor bed. Postoperative external beam radiotherapy excluded the usual boost. One patient from the original series (Vaidya JS, Baum M, Tobias JS et al. Targeted intraoperative radiotherapy [TARGIT] yields very low recurrence rates when given as a boost. Int J Rad Oncol Biol Phys 66:1335–1338, 2006) did not receive external beam radiotherapy and is now excluded, but remains recurrence free after 51 months. Results: The treatment was well tolerated. At median follow-up of 49 months, 5 patients (1.66%) had local recurrence. The Kaplan-Meier estimate of local recurrence at 5 years is 1.52% (SE=0.76%). This compares very favorably with the 4.3% recurrence rate in boosted patients from the EORTC boost study in which only 8.1% patients were node-positive, as opposed to 29% in our series. Conclusions: It appears that lumpectomy and Targit boost combined with external beam radiotherapy results in an exceptionally low local recurrence rate. This could be attributed to both accurate geometry of the boost and timeliness of the treatment. Irradiation of the tumour bed at the time of surgery might also provide a favorable effect on the micro-environment of any residual disease (Belletti B, Vaidya JS, D’Andrea S, et al. Targeted intraoperative radiotherapy [TARGIT] impairs surgical wound-stimulated breast cancer cell proliferation and invasion. Clin Cancer Res [in press], 2008). These results suggest that not only could Targit be safely used as a boost, but that it is likely to be superior to conventional external boost.

    @inproceedings{vaidya2008efficacyresults,
    author = "Vaidya, JS and Baum, M and Tobias, JS and et, A",
    booktitle = "Journal of Clinical Oncology",
    month = "May",
    pages = "565",
    title = "Efficacy of targeted intraoperative radiotherapy (Targit) boost after breast-conserving surgery: updated results",
    url = "http://www.asco.org/ASCOv2/Meetings/Abstracts?\\&vmview=abst_detail_view\\&confID=55\\&abstractID=33499",
    volume = "26",
    year = "2008",
    abstract = "Background: In 1998 we started a phase II study of TARGeted Intraoperative radioTherapy (TARGIT) using the Intrabeam system. We present the updated results of this first group of breast cancer patients treated with breast-conserving surgery where Targit was used as a boost to the tumor bed. Methods: We treated 301 cancers in 300 patients undergoing breast- conserving surgery with no other selection criteria. 97 patients were younger than 51 years, 57% of cancers were between 1 to 2cm, (21% > 2cm), 29% had a grade 3 tumor and 29% were node positive. After lumpectomy, 20Gy was delivered intraoperatively using 50 kV X-rays to the surface of the tumor bed. Postoperative external beam radiotherapy excluded the usual boost. One patient from the original series (Vaidya JS, Baum M, Tobias JS et al. Targeted intraoperative radiotherapy [TARGIT] yields very low recurrence rates when given as a boost. Int J Rad Oncol Biol Phys 66:1335–1338, 2006) did not receive external beam radiotherapy and is now excluded, but remains recurrence free after 51 months. Results: The treatment was well tolerated. At median follow-up of 49 months, 5 patients (1.66%) had local recurrence. The Kaplan-Meier estimate of local recurrence at 5 years is 1.52% (SE=0.76%). This compares very favorably with the 4.3% recurrence rate in boosted patients from the EORTC boost study in which only 8.1% patients were node-positive, as opposed to 29% in our series. Conclusions: It appears that lumpectomy and Targit boost combined with external beam radiotherapy results in an exceptionally low local recurrence rate. This could be attributed to both accurate geometry of the boost and timeliness of the treatment. Irradiation of the tumour bed at the time of surgery might also provide a favorable effect on the micro-environment of any residual disease (Belletti B, Vaidya JS, D'Andrea S, et al. Targeted intraoperative radiotherapy [TARGIT] impairs surgical wound-stimulated breast cancer cell proliferation and invasion. Clin Cancer Res [in press], 2008). These results suggest that not only could Targit be safely used as a boost, but that it is likely to be superior to conventional external boost.",
    issue = "15S",
    day = "15",
    publicationstatus = "published",
    }

  • Keshtgar, M., Tobias, J., Vaidya, J., Williams, N., Stacey, C., Metaxas, M., Douek, M., Brew-Graves, C. & Baum, M. (2008) Breast cancer patients treated with intra-operative radiotherapy [IORT] alone when conventional external beam radiation therapy [EBRT] was not possible. IN JOURNAL OF CLINICAL ONCOLOGY, 26..
    [BibTeX] [Download PDF]
    @article{keshtgar2008breastpossible,
    author = "Keshtgar, M and Tobias, JS and Vaidya, JS and Williams, N and Stacey, C and Metaxas, M and Douek, M and Brew-Graves, C and Baum, M",
    journal = "JOURNAL OF CLINICAL ONCOLOGY",
    month = "May",
    title = "Breast cancer patients treated with intra-operative radiotherapy [IORT] alone when conventional external beam radiation therapy [EBRT] was not possible",
    url = "http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2\\&SrcApp=PARTNER_APP\\&SrcAuth=LinksAMR\\&KeyUT=000208457400039\\&DestLinkType=FullRecord\\&DestApp=ALL_WOS\\&UsrCustomerID=f41074198c063036414efcbc916f8956",
    volume = "26",
    year = "2008",
    issn = "0732-183X",
    issue = "15",
    day = "20",
    }

  • Jones, L., Law, P. & Vaidya, J. (2008) \"Cancer\" is described as the diagnosis by three times as many patients scheduled for mastectomy compared with breast conserving surgery PERGAMON-ELSEVIER SCIENCE LTD, 90-91.
    [BibTeX]
    @inproceedings{jones2008cancersurgery,
    author = "Jones, L and Law, P and Vaidya, JS",
    booktitle = "EJC SUPPLEMENTS",
    month = "Apr",
    organization = "Berlin, GERMANY",
    pages = "90--91",
    publisher = "PERGAMON-ELSEVIER SCIENCE LTD",
    title = "\"Cancer\" is described as the diagnosis by three times as many patients scheduled for mastectomy compared with breast conserving surgery",
    volume = "6",
    year = "2008",
    startyear = "2008",
    startmonth = "Apr",
    startday = "15",
    finishyear = "2008",
    finishmonth = "Apr",
    finishday = "19",
    issn = "1359-6349",
    issue = "7",
    language = "EN",
    conference = "6th European Breast Cancer Conference",
    }

  • Vaidya, J. & Gadgil, S. (2008) Estimation of the proportion of patients in whom an experimental treatment is effective in a positive randomised trial, using a novel variance-guided equation PERGAMON-ELSEVIER SCIENCE LTD, 113-113.
    [BibTeX]
    @inproceedings{vaidya2008estimationequation,
    author = "Vaidya, JS and Gadgil, S",
    booktitle = "EJC SUPPLEMENTS",
    month = "Apr",
    organization = "Berlin, GERMANY",
    pages = "113--113",
    publisher = "PERGAMON-ELSEVIER SCIENCE LTD",
    title = "Estimation of the proportion of patients in whom an experimental treatment is effective in a positive randomised trial, using a novel variance-guided equation",
    volume = "6",
    year = "2008",
    startyear = "2008",
    startmonth = "Apr",
    startday = "15",
    finishyear = "2008",
    finishmonth = "Apr",
    finishday = "19",
    issn = "1359-6349",
    issue = "7",
    language = "EN",
    conference = "6th European Breast Cancer Conference",
    }

  • Belletti, B., Vaidya, J., D’Andrea, S., Entschladen, F., Roncadin, M., Lovat, F., Berton, S., Perin, T., Candiani, E., Reccanello, S., Veronesi, A., Canzonieri, V., Trovò, M., Zaenker, K., Colombatti, A., Baldassarre, G. & Massarut, S. (2008) Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding.. IN Clin Cancer Res, 14.1325-1332. doi:10.1158/1078-0432.CCR-07-4453
    [BibTeX] [Abstract] [Download PDF]

    After apparently successful excision of breast cancer, risk of local recurrence remains high mainly in the area surrounding the original tumor, indicating that wound healing processes may be implicated. The proportional reduction of this risk by radiotherapy does not depend on the extent of surgery, suggesting that radiotherapy, in addition to killing tumor cells, may influence the tumor microenvironment.

    @article{belletti2008targetedwounding.,
    author = "Belletti, B and Vaidya, JS and D'Andrea, S and Entschladen, F and Roncadin, M and Lovat, F and Berton, S and Perin, T and Candiani, E and Reccanello, S and Veronesi, A and Canzonieri, V and Trovò, MG and Zaenker, KS and Colombatti, A and Baldassarre, G and Massarut, S",
    journal = "Clin Cancer Res",
    month = "Mar",
    organization = "United States",
    pages = "1325--1332",
    title = "Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/18316551",
    volume = "14",
    year = "2008",
    abstract = "After apparently successful excision of breast cancer, risk of local recurrence remains high mainly in the area surrounding the original tumor, indicating that wound healing processes may be implicated. The proportional reduction of this risk by radiotherapy does not depend on the extent of surgery, suggesting that radiotherapy, in addition to killing tumor cells, may influence the tumor microenvironment.",
    doi = "10.1158/1078-0432.CCR-07-4453",
    issn = "1078-0432",
    issue = "5",
    keyword = "Animals",
    keyword = "Breast",
    keyword = "Breast Neoplasms",
    keyword = "Cell Movement",
    keyword = "Cell Proliferation",
    keyword = "Cells, Cultured",
    keyword = "Disease Progression",
    keyword = "Endothelium, Vascular",
    keyword = "Female",
    keyword = "Follow-Up Studies",
    keyword = "Humans",
    keyword = "Intraoperative Care",
    keyword = "Mammary Glands, Animal",
    keyword = "Mastectomy, Segmental",
    keyword = "Mice",
    keyword = "Middle Aged",
    keyword = "NIH 3T3 Cells",
    keyword = "Neoplasm Invasiveness",
    keyword = "Neoplasm Recurrence, Local",
    keyword = "Pilot Projects",
    keyword = "Proteomics",
    keyword = "Radiotherapy Dosage",
    keyword = "Umbilical Veins",
    language = "eng",
    pii = "14/5/1325",
    day = "1",
    }

  • Baum, M., Williams, N., Vaidya, J., Keshtgar, M. & Tobias, J. (2008) TARGIT: an international trial of intraoperative versus external beam radiotherapy BIOMED CENTRAL LTD, S37–S38. doi:10.1186/bcr1957
    [BibTeX]
    @inproceedings{baum2008targit:radiotherapy,
    author = "Baum, M and Williams, N and Vaidya, J and Keshtgar, M and Tobias, J",
    booktitle = "BREAST CANCER RESEARCH",
    month = "Feb",
    organization = "London, ENGLAND",
    pages = "S37--S38",
    publisher = "BIOMED CENTRAL LTD",
    title = "TARGIT: an international trial of intraoperative versus external beam radiotherapy",
    volume = "10",
    year = "2008",
    doi = "10.1186/bcr1957",
    startyear = "2008",
    startmonth = "May",
    startday = "13",
    issn = "1465-5411",
    issue = "Suppl. 2",
    keyword = "BREAST-CANCER",
    keyword = "MULTICENTRICITY",
    keyword = "RECURRENCE",
    language = "EN",
    conference = "Breast Cancer Research Meeting",
    }

  • Vaidya, J. & Gadgil, S. (2008) Estimation of the proportion of patients in whom an experimental treatment is effective in a positive randomised trial, using a novel variance-guided equation , 220.
    [BibTeX]
    @inproceedings{vaidya2008estimationequation,
    author = "Vaidya, JS and Gadgil, S",
    booktitle = "Eur J Cancer",
    pages = "220",
    title = "Estimation of the proportion of patients in whom an experimental treatment is effective in a positive randomised trial, using a novel variance-guided equation",
    volume = "6",
    year = "2008",
    issue = "7",
    }

  • Keshtgar, M., Tobias, J., Vaidya, J. & et , A. (2008) Use of intra-operative radiotherapy [IORT] alone in breast cancer patients when conventional external beam radiation therapy [EBRT] was not possible , 330.
    [BibTeX]
    @inproceedings{keshtgar2008usepossible,
    author = "Keshtgar, M and Tobias, J and Vaidya, JS and et, A",
    booktitle = "Eur J Cancer",
    pages = "330",
    title = "Use of intra-operative radiotherapy [IORT] alone in breast cancer patients when conventional external beam radiation therapy [EBRT] was not possible",
    volume = "6",
    year = "2008",
    issue = "7",
    }

  • Enderling, H. & Vaidya, J. (2008) Mathematical Modelling of Breast Carcinogenesis, Treatment with Surgery and Radiotherapy and Local Recurrence. IN Bellomo, N., Chaplain, M. & Angelis, E. (Eds.), Selected topics in cancer modeling: Genesis, Evolution, Immune Competition and Therapy.. doi:10.1007/978-0-8176-4713-1_13
    [BibTeX] [Abstract]

    The complexity of these different levels requires the development of new mathematical methods and ideas, which are examined in this work.Written by first-rate …

    @incollection{enderling2008mathematicalrecurrence,
    author = "Enderling, H and Vaidya, JS",
    booktitle = "Selected topics in cancer modeling: Genesis, Evolution, Immune Competition and Therapy",
    editor = "Bellomo, N and Chaplain, M and Angelis, ED",
    number = "13",
    pages = "337--362",
    publisher = "Birkhauser Boston",
    school = "New York, USA",
    series = "Modelling and Simulation in Science, Engineering and Technology",
    title = "Mathematical Modelling of Breast Carcinogenesis, Treatment with Surgery and Radiotherapy and Local Recurrence",
    year = "2008",
    abstract = "The complexity of these different levels requires the development of new mathematical methods and ideas, which are examined in this work.Written by first-rate ...",
    doi = "10.1007/978-0-8176-4713-1_13",
    isbn = "0817647120",
    isbn = "9780817647124",
    keyword = "Mathematics",
    }

  • Vaidya, J. (2008) Reduction in HRT use is not associated with a reduction in breast cancer incidence in Scotland. IN Journal of National Cancer Institute, 100.598-599. doi:10.1093/jnci/djn080
    [BibTeX]
    @article{vaidya2008reductionscotland,
    author = "Vaidya, JS",
    journal = "Journal of National Cancer Institute",
    pages = "598--599",
    title = "Reduction in HRT use is not associated with a reduction in breast cancer incidence in Scotland",
    volume = "100",
    year = "2008",
    doi = "10.1093/jnci/djn080",
    issue = "8",
    }

  • Belletti, B., Vaidya, J., D Andrea, S., Entschladen, F., Roncadin, M., Lovat, F., Berton, F., Perin, T., Candiani, E., Reccanello, S., Veronesi, A., Canzonieri, V., Trovò, M., Zaenker, K., Colombatti, A., Baldassarre, G. & Massarut, S. (2008) Targeted Intraoperative radiotherapy (TARGIT) impairs surgical wound-stimulated breast cancer cell proliferation and invasion. IN Clinical Cancer Research, 14..
    [BibTeX] [Download PDF]
    @article{belletti2008targetedinvasion,
    author = "Belletti, B and Vaidya, JS and D Andrea, S and Entschladen, F and Roncadin, M and Lovat, F and Berton, F and Perin, T and Candiani, E and Reccanello, S and Veronesi, A and Canzonieri, V and Trovò, MG and Zaenker, KS and Colombatti, A and Baldassarre, G and Massarut, S",
    journal = "Clinical Cancer Research",
    title = "Targeted Intraoperative radiotherapy (TARGIT) impairs surgical wound-stimulated breast cancer cell proliferation and invasion",
    url = "http://clincancerres.aacrjournals.org/content/14/5/1325.abstract",
    volume = "14",
    year = "2008",
    issn = "1078-0432",
    issue = "5",
    }

  • Song, C., Purdie, C., Brown, S., Frank, T. & Vaidya, J. (2008) Dynamic response to heat- a novel physical characteristic of breast cancer.When a breast specimen is heated- the cancer warms up less than the normal tissues. Was widely reported around the world media (25-30 May 2008). IN International Journal of Surgery, 6.357-358. doi:10.1016/j.ijsu.2008.02.002
    [BibTeX]
    @article{song2008dynamic2008,
    author = "Song, C and Purdie, C and Brown, S and Frank, T and Vaidya, JS",
    journal = "International Journal of Surgery",
    pages = "357--358",
    title = "Dynamic response to heat- a novel physical characteristic of breast cancer.When a breast specimen is heated- the cancer warms up less than the normal tissues.
    Was widely reported around the world media (25-30 May 2008)",
    volume = "6",
    year = "2008",
    doi = "10.1016/j.ijsu.2008.02.002",
    issn = "1743-9191",
    issue = "4",
    }

  • Ansari, B. & Vaidya, J. (2008) Reduced adhesion formation following laparoscopic versus open colorectal surgery. IN British Journal of Surgery, 95.909-914.
    [BibTeX] [Download PDF]
    @article{ansari2008reducedsurgery,
    author = "Ansari, B and Vaidya, JS",
    journal = "British Journal of Surgery",
    pages = "909--914",
    title = "Reduced adhesion formation following laparoscopic versus open colorectal surgery",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/18991311",
    volume = "95",
    year = "2008",
    issn = "0007-1323",
    issue = "7",
    }

  • Baum, M., Vaidya & J, S. (2008) Targeted intra-operative radiotherapy—TARGIT for early breast cancer: Can we spare the patient’s daily journeys to the radiotherapist?. IN Annals of the New York Academy of Sciences, 1138.132-135. doi:10.1196/annals.1414.019
    [BibTeX]
    @article{baum2008targetedradiotherapist?,
    author = "Baum, M and Vaidya and J, S",
    journal = "Annals of the New York Academy of Sciences",
    pages = "132--135",
    title = "Targeted intra-operative radiotherapy—TARGIT for early breast cancer: Can we spare the patient’s daily journeys to the radiotherapist?",
    volume = "1138",
    year = "2008",
    doi = "10.1196/annals.1414.019",
    issn = "0077-8923",
    }

  • Jones, L., Law, P. & Vaidya, J. (2008) “Cancer” is described as their diagnosis by three times as many patients scheduled for mastectomy compared with those scheduled for breast conserving surgery , 146.
    [BibTeX]
    @inproceedings{jones2008cancersurgery,
    author = "Jones, LT and Law, P and Vaidya, JS",
    booktitle = "Eur J Cancer",
    pages = "146",
    title = "“Cancer” is described as their diagnosis by three times as many patients scheduled for mastectomy compared with those scheduled for breast conserving surgery",
    volume = "6",
    year = "2008",
    issue = "7",
    }

  • Sardessai, S., Agrawal, B. & Vaidya, J. (2008) 56. Muskaan-A trust for persons with cancer, a voluntary organization providing the only psychosocial, physical, cosmetic and financial support for breast cancer patients in Goa, India .
    [BibTeX]
    @inproceedings{sardessai200856.muskaan-aindia,
    author = "Sardessai, SG and Agrawal, B and Vaidya, JS",
    booktitle = "(PUB-401) UICC World Cancer congress 2008",
    title = "56.  Muskaan-A trust for persons with cancer, a voluntary organization providing the only psychosocial, physical, cosmetic and financial support for breast cancer patients in Goa, India",
    year = "2008",
    }

  • Keshtgar, M., Tobias, J., Vaidya, J., Stacey, C., Corica, T., Joseph, D., Keller, A., Wenz, F., Williams N R, B. & M (2008) Breast cancer patients treated with intra-operative radiotherapy alone when conventional external beam radiation therapy was not possible. IN Ejc Supplements, 6.146-146.
    [BibTeX]
    @article{keshtgar2008breastpossible,
    author = "Keshtgar, M and Tobias, JS and Vaidya, JS and Stacey, C and Corica, T and Joseph, D and Keller, A and Wenz, F and Williams N R, B and M",
    journal = "Ejc Supplements",
    pages = "146--146",
    title = "Breast cancer patients treated with intra-operative radiotherapy alone when conventional external beam radiation therapy was not possible",
    volume = "6",
    year = "2008",
    issn = "1359-6349",
    issue = "7",
    keyword = "Breast cancer",
    keyword = "radiotherapy",
    keyword = "IORT",
    keyword = "TARGIT",
    }

  • Vaidya, J. (2008) A method to test whether late extended letrozole, rather than self selection, improves the outcome in breast cancer patients who have completed 5 years of tamoxifen.. IN Journal of Clinical Oncology, ..
    [BibTeX] [Download PDF]
    @article{vaidya2008atamoxifen.,
    author = "Vaidya, JS",
    journal = "Journal of Clinical Oncology",
    title = "A method to test whether late extended letrozole, rather than self selection, improves the outcome in breast cancer patients who have completed 5 years of tamoxifen.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/18591569",
    year = "2008",
    issn = "0732-183X",
    }

  • Vaidya, J. & Osborne, M. (2008) An uncommon scinti-scan during sentinel node biopsy – an optical illusion. IN International Journal of Surgery, 6.422-423.
    [BibTeX]
    @article{vaidya2008anillusion,
    author = "Vaidya, J and Osborne, M",
    journal = "International Journal of Surgery",
    pages = "422--423",
    title = "An uncommon scinti-scan during sentinel node biopsy – an optical illusion",
    volume = "6",
    year = "2008",
    issn = "1743-9191",
    issue = "5",
    }

  • Vaidya, J., Alem, F. & Mansor, F. (2007) A stitch in time did not save nine–because ït was not my field\".. IN Int J Surg, 5.371. doi:10.1016/j.ijsu.2006.06.016
    [BibTeX] [Download PDF]
    @article{vaidya2007afield.,
    author = "Vaidya, JS and Alem, F and Mansor, F",
    journal = "Int J Surg",
    month = "Oct",
    organization = "England",
    pages = "371",
    title = "A stitch in time did not save nine--because \"it was not my field\".",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17933697",
    volume = "5",
    year = "2007",
    doi = "10.1016/j.ijsu.2006.06.016",
    eissn = "1743-9159",
    issue = "5",
    keyword = "Aged",
    keyword = "Female",
    keyword = "Gastrointestinal Hemorrhage",
    keyword = "Humans",
    keyword = "Ileostomy",
    keyword = "Medicine",
    keyword = "Specialization",
    keyword = "Suture Techniques",
    language = "eng",
    pii = "S1743-9191(06)00143-9",
    }

  • Vaidya, J. (2007) Breast cancer: an artistic view. IN The Lancet Oncology, 8.583-585. doi:10.1016/S1470-2045(07)70200-0
    [BibTeX]
    @article{vaidya2007breastview,
    author = "Vaidya, JS",
    journal = "The Lancet Oncology",
    month = "Jul",
    pages = "583--585",
    title = "Breast cancer: an artistic view",
    volume = "8",
    year = "2007",
    doi = "10.1016/S1470-2045(07)70200-0",
    issn = "1470-2045",
    issue = "7",
    keyword = "Breast cancer",
    keyword = "art",
    keyword = "rennaissance",
    keyword = "coping",
    }

  • Hadad, S., Vaidya, J., Baker, L., Koh, H., Heron, T. & Thompson, A. (2007) Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis. IN World Journal of Surgery, 31.1300-1303. doi:10.1007/s00268-007-9050-2
    [BibTeX] [Abstract] [Download PDF]

    BACKGROUND: Randomized trials suggest that laparoscopic cholecystectomy should be performed on first admission for acute cholecystitis. However, this is not widely practiced, possibly because of a perceived high conversion rate. We hypothesized that delay from onset of symptoms may increase the conversion rate. METHODS: We performed a retrospective case note review of patients undergoing emergency cholecystectomy in a single institution between January 2002 and December 2005. We analyzed whether delay from onset of symptoms was related to the conversion rate in patients with a histopathological diagnosis of acute cholecystitis. RESULTS: Of patients who underwent emergency laparoscopic cholecystectomy in our institution, 32.4% (197/608) had acute cholecystitis on histopathology. The conversion rate of those with acute cholecystitis was considerably higher (24.4%) than for those with other pathologies (6.3%). For patients with acute cholecystitis, the conversion rates increased with duration of symptoms: 9.5%, 16.1%, 38.9%, and 38.6% for delays of 0-2 days, 3-4 days, 5-6 days, and > 6 days from symptom onset, respectively (chi-square for trend = 14.2

    @article{hadad2007delaycholecystitis,
    author = "Hadad, SM and Vaidya, JS and Baker, L and Koh, HC and Heron, TP and Thompson, AM",
    journal = "World Journal of Surgery",
    month = "Jun",
    pages = "1300--1303",
    title = "Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17483986",
    volume = "31",
    year = "2007",
    abstract = "BACKGROUND: Randomized trials suggest that laparoscopic cholecystectomy should be performed on first admission for acute cholecystitis. However, this is not widely practiced, possibly because of a perceived high conversion rate. We hypothesized that delay from onset of symptoms may increase the conversion rate. METHODS: We performed a retrospective case note review of patients undergoing emergency cholecystectomy in a single institution between January 2002 and December 2005. We analyzed whether delay from onset of symptoms was related to the conversion rate in patients with a histopathological diagnosis of acute cholecystitis. RESULTS: Of patients who underwent emergency laparoscopic cholecystectomy in our institution, 32.4% (197/608) had acute cholecystitis on histopathology. The conversion rate of those with acute cholecystitis was considerably higher (24.4%) than for those with other pathologies (6.3%). For patients with acute cholecystitis, the conversion rates increased with duration of symptoms: 9.5%, 16.1%, 38.9%, and 38.6% for delays of 0-2 days, 3-4 days, 5-6 days, and > 6 days from symptom onset, respectively (chi-square for trend = 14.27, DF = 1, p = 0.00016). Most conversions were due to the presence of acute inflammatory adhesions. CONCLUSIONS: Early intervention for acute cholecystitis (preferably within 2 days of onset of symptoms) is most likely to result in successful laparoscopic cholecystectomy; increasing delay is associated with conversion to open surgery.",
    doi = "10.1007/s00268-007-9050-2",
    issn = "0364-2313",
    issue = "6",
    keyword = "laparoscopic cholecystectomy",
    keyword = "optimum time",
    keyword = "delay",
    keyword = "open",
    keyword = "conversion rates",
    }

  • Vaidya, J. (2007) Partial breast irradiation using targeted intraoperative radiotherapy (Targit). IN Nature Clinical Practice Oncology, 4.384-385. doi:10.1038/ncponc0850
    [BibTeX] [Download PDF]
    @article{vaidya2007partialtargit,
    author = "Vaidya, JS",
    journal = "Nature Clinical Practice Oncology",
    month = "Jun",
    pages = "384--385",
    title = "Partial breast irradiation using targeted intraoperative radiotherapy (Targit)",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17549089",
    volume = "4",
    year = "2007",
    doi = "10.1038/ncponc0850",
    issn = "1743-4254",
    issue = "7",
    keyword = "Targit",
    keyword = "Intraoperative radiotherapy",
    keyword = "IORT",
    keyword = "boost",
    keyword = "radiation therapy",
    keyword = "early breast cancer",
    day = "5",
    }

  • Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., Gardner, J., Munro, A. & Eljamel, S. (2007) Implementation and experiences of an intraoperative radiotherapy service , S8–S9.
    [BibTeX]
    @inproceedings{armoogum2007implementationservice,
    author = "Armoogum, K and Parry, J and Mackay, C and Thompson, A and Vaidya, JS and Ackland, C and Gardner, J and Munro, A and Eljamel, S",
    booktitle = "Clin Oncol (R Coll Radiol)",
    pages = "S8--S9",
    title = "Implementation and experiences of an intraoperative radiotherapy service",
    volume = "19",
    year = "2007",
    issue = "3",
    }

  • Vaidya, J. & Massarut, S. (2007) Increased tissue stiffness during mammography may contribute to carcinogenesis. IN International Journal of Surgery, 5.213.
    [BibTeX] [Download PDF]
    @article{vaidya2007increasedcarcinogenesis,
    author = "Vaidya, JS and Massarut, S",
    journal = "International Journal of Surgery",
    pages = "213",
    title = "Increased tissue stiffness during mammography may contribute to carcinogenesis",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17509506",
    volume = "5",
    year = "2007",
    issn = "1743-9191",
    issue = "3",
    }

  • Vaidya, J. (2007) Locally advanced breast cancer in a 15th century painting in Milan. IN The Breast, 16.102-103. doi:10.1016/j.breast.2006.09.002
    [BibTeX] [Download PDF]
    @article{vaidya2007locallymilan,
    author = "Vaidya, JS",
    journal = "The Breast",
    pages = "102--103",
    title = "Locally advanced breast cancer in a 15th century painting in Milan",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17081754",
    volume = "16",
    year = "2007",
    doi = "10.1016/j.breast.2006.09.002",
    issn = "0960-9776",
    issue = "1",
    }

  • Massarut, S., Baldassarre, G., Belletti, B., Colombatti, A., D’Andrea, S., Candiani, E., Perin, T., Reccanello, S., Roncadin, M. & Vaidya, J. (2007) Erratum: Intraoperative radiotherapy impairs breast cancer cell motility induced by surgical wound fluid (Journal of Clinical Oncology (2006) 24, (10611)). IN Journal of Clinical Oncology, 25.1154-1154.
    [BibTeX]
    @article{massarut2007erratum:10611,
    author = "Massarut, S and Baldassarre, G and Belletti, B and Colombatti, A and D'Andrea, S and Candiani, E and Perin, T and Reccanello, S and Roncadin, M and Vaidya, JS",
    journal = "Journal of Clinical Oncology",
    pages = "1154--1154",
    title = "Erratum: Intraoperative radiotherapy impairs breast cancer cell motility induced by surgical wound fluid (Journal of Clinical Oncology (2006) 24, (10611))",
    volume = "25",
    year = "2007",
    issn = "0732-183X",
    issue = "9",
    }

  • Vaidya, J. (2007) Junior Doctors should have a parallel postgraduate student contract. IN International Journal of Surgery, .. doi:10.1016/j.ijsu.2006.05.015
    [BibTeX] [Abstract] [Download PDF]

    All of us are acutely aware of the low level of training opportunity that is now available to Junior Doctors. The big mistake is in accepting that everything the trainees do is ‘‘work’’ and hence European Working Time Directive (EWTD) applies to it all. But Junior Doctor training is an apprenticeship which is a combination of service (work) and training/learning. Hence these should be formally distinguished, and EWTD should apply only to the work part. For example, an SpR should have the stipulated 48 (or 30!) hours per week of WORK and another 30 of 40 (or as many as we þ they decide are required) hours per week of LEARNING which is formally timetabled and NOT counted as work. Or better e we formally stipulate that 40% of the time a Junior Doctor is in the hospital he/she is purely learning and 60% is purely working. This may sound artificial, but is necessary for protecting the very existence of surgical and medical training. If that is accepted e then they can be around to learn for 66% longer. So out of the 80 hours a trainee is in the hospital, 48 hours is work and 32 hours is learning. OR, of the 90 hours a trainee is in the hospital, 54 hours is work and 36 hours is learning or postgraduate studentship. Of course, no salary need be paid for these learning/postgraduate studentship hours, and they are not included in the EWTD hours count. Such work þ postgraduate studentship will then match the training most of us have undergone; and if implemented the eager trainees will be ‘‘allowed’’ to be in their alma mater e the place of learning e the hospital e long enough for adequate training/education. This is a simple concept, but if this model works, it could be applied to the rest of the World.

    @article{vaidya2007juniorcontract,
    author = "Vaidya, JS",
    journal = "International Journal of Surgery",
    title = "Junior Doctors should have a parallel postgraduate student contract",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17660138",
    year = "2007",
    abstract = "All of us are acutely aware of the low level of training
    opportunity that is now available to Junior Doctors.
    The big mistake is in accepting that everything the
    trainees do is ‘‘work’’ and hence European Working Time
    Directive (EWTD) applies to it all.
    But Junior Doctor training is an apprenticeship which is
    a combination of service (work) and training/learning.
    Hence these should be formally distinguished, and EWTD
    should apply only to the work part.
    For example, an SpR should have the stipulated 48 (or
    30!) hours per week of WORK and another 30 of 40 (or as
    many as we þ they decide are required) hours per week of
    LEARNING which is formally timetabled and NOT counted as
    work. Or better e we formally stipulate that 40% of the
    time a Junior Doctor is in the hospital he/she is purely
    learning and 60% is purely working. This may sound
    artificial, but is necessary for protecting the very existence of surgical and medical training. If that is accepted e then they can be around to learn for 66% longer. So out of the 80 hours a trainee is in the hospital, 48 hours is work and 32 hours is learning. OR, of the 90 hours a trainee is in the hospital, 54 hours is work and 36 hours is learning or postgraduate studentship. Of course, no salary need be paid for these learning/postgraduate studentship hours, and they are not included in the EWTD hours count. Such work þ postgraduate studentship will then match the training most of us have undergone; and if implemented the eager trainees will be ‘‘allowed’’ to be in their alma mater e the place of learning e the hospital e long enough for adequate training/education. This is a simple concept, but if this model works, it could be applied to the rest of the World.",
    doi = "10.1016/j.ijsu.2006.05.015",
    issn = "1743-9191",
    }

  • Armoogum, K., Parry, J., Mackay, C., Thompson, A., Vaidya, J., Ackland, C., Gardner, J. & Munro, A. (2007) Measurement of Skin Dose from Very Low Energy X-rays during Partial Breast Irradiation , S23.
    [BibTeX]
    @inproceedings{armoogum2007measurementirradiation,
    author = "Armoogum, K and Parry, J and Mackay, C and Thompson, A and Vaidya, J and Ackland, C and Gardner, J and Munro, A",
    booktitle = "Clin Oncol (R Coll Radiol)",
    pages = "S23",
    title = "Measurement of Skin Dose from Very Low Energy X-rays during Partial Breast Irradiation",
    volume = "19",
    year = "2007",
    issue = "3",
    }

  • Song, C., Brown, S., Purdie, C., Frank, T. & Vaidya, J. (2007) Dynamic thermography for tumour margins during surgery , 258.
    [BibTeX]
    @inproceedings{song2007dynamicsurgery,
    author = "Song, C and Brown, S and Purdie, C and Frank, T and Vaidya, J",
    booktitle = "Minimally Invasive Therapy",
    pages = "258",
    title = "Dynamic thermography for tumour margins during surgery",
    volume = "16",
    year = "2007",
    issue = "5",
    }

  • Enderling, H., Anderson, A., Chaplain, M. & Vaidya, J. (2007) A mathematical model of breast cancer development,local treatment and recurrence.. IN Journal of Theoretical Biology, 246.245-259. doi:10.1016/j.jtbi.2006.12.010
    [BibTeX] [Download PDF]
    @article{enderling2007arecurrence.,
    author = "Enderling, H and Anderson, ARA and Chaplain, MAJ and Vaidya, JS",
    journal = "Journal of Theoretical Biology",
    pages = "245--259",
    title = "A mathematical model of breast cancer development,local treatment and recurrence.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17289081",
    volume = "246",
    year = "2007",
    doi = "10.1016/j.jtbi.2006.12.010",
    issn = "0022-5193",
    issue = "2",
    keyword = "Targit",
    keyword = "Intraoperative radiotherapy",
    keyword = "mathematical modelling",
    keyword = "radiation therapy",
    }

  • Vaidya, J. (2007) An alternative model of cancer spread and metastasis. IN International Journal of Surgery, 5.73-75.
    [BibTeX]
    @article{vaidya2007anmetastasis,
    author = "Vaidya, JS",
    journal = "International Journal of Surgery",
    pages = "73--75",
    title = "An alternative model of cancer spread and metastasis",
    volume = "5",
    year = "2007",
    issn = "1743-9191",
    issue = "2",
    }

  • Vaidya, J., Baum, M., Tobias, J., Massarut, S., Wenz, F., Murphy, O., Hilaris, B., Houghton, J., Saunders, C., Corica, T., Roncadin, M., Kraus-Tiefenbacher, U., Melchaert, F., Keshtgar, M., Sainsbury, R., Douek, M., Harrison, E., Thompson, A. & Joseph, D. (2006) Targeted intraoperative radiotherapy (targit) yields very low recurrence rates when given as a boost. IN INT J RADIAT ONCOL, 66.1335-1338. doi:10.1016/j.ijrobp.2006.07.1378
    [BibTeX] [Abstract]

    Purpose: Patients undergoing breast-conserving surgery were offered boost radiotherapy with targeted intraoperative radiotherapy (TARGIT) using the Intrabeam system to test the feasibility, safety, and efficacy of the new approach.Methods and Materials: We treated 302 cancers in 301 unselected patients. This was not a low-risk group. One-third of patients (98/301) were younger than 51 years of age. More than half of the tumors (172, 57%) were between 1 cm and 2 cm, and one-fifth (62, 21%) were > 2 cm; 29% (86) had a Grade 3 tumor and, in 29% (87), axillary lymph nodes contained metastasis. After primary surgery, 20 Gy was delivered intraoperatively to the surface of the tumor bed, followed by external-beam radiotherapy (EBRT), but excluding the usual boost.Results: The treatment was well tolerated. The follow-up ranged from 3 to 80 months (164 and 90 patients completed 2 and 3 years follow-up, respectively). Four patients (1.3%) had local recurrence. The Kaplan-Meier estimate of local recurrence is 2.6% (SE = 1.7) at 5 years. This compares favorably with the 4.3% recurrence rate in boosted patients from the EORTC boost study, in which only 8.1% patients were node-positive, as opposed to 29% in our series.Conclusion: Targeted intraoperative radiotherapy combined with EBRT results in a low local recurrence rate. This could be attributed to both accurate targeting and timeliness of the treatment. These data support the need for a randomized trial to test whether the TARGIT boost is superior to conventional external boost, especially in high-risk women. (c) 2006 Elsevier Inc.

    @article{vaidya2006targetedboost,
    address = "Univ Dundee, Ninewells Hosp \\& Med Sch, Dept Surg, Dept Mol Oncol, Dundee DD1 2UY, Scotland and UCL, Dept Surg \\& Radiat Oncol, London, England and Ctr Riferimento Oncol, Dept Surg \\& Radiat Oncol, I-33081 Aviano, Italy and Univ Mannheim, Med Ctr, Mannheim, Germany and Univ Western Australia, Dept Radiat Oncol, Sir Charles Gairdner Hosp, Perth, WA 6009, Australia and Univ Western Australia, Sch Surg \\& Pathol, Perth, WA 6009, Australia and New York Med Coll, Dept Radiat Oncol, New York, NY USA",
    author = "Vaidya, JS and Baum, M and Tobias, JS and Massarut, S and Wenz, F and Murphy, O and Hilaris, B and Houghton, J and Saunders, C and Corica, T and Roncadin, M and Kraus-Tiefenbacher, U and Melchaert, F and Keshtgar, M and Sainsbury, R and Douek, M and Harrison, E and Thompson, A and Joseph, D",
    journal = "INT J RADIAT ONCOL",
    month = "Dec",
    pages = "1335--1338",
    publisher = "ELSEVIER SCIENCE INC",
    title = "Targeted intraoperative radiotherapy (targit) yields very low recurrence rates when given as a boost",
    volume = "66",
    year = "2006",
    abstract = "Purpose: Patients undergoing breast-conserving surgery were offered boost radiotherapy with targeted intraoperative radiotherapy (TARGIT) using the Intrabeam system to test the feasibility, safety, and efficacy of the new approach.Methods and Materials: We treated 302 cancers in 301 unselected patients. This was not a low-risk group. One-third of patients (98/301) were younger than 51 years of age. More than half of the tumors (172, 57%) were between 1 cm and 2 cm, and one-fifth (62, 21%) were > 2 cm; 29% (86) had a Grade 3 tumor and, in 29% (87), axillary lymph nodes contained metastasis. After primary surgery, 20 Gy was delivered intraoperatively to the surface of the tumor bed, followed by external-beam radiotherapy (EBRT), but excluding the usual boost.Results: The treatment was well tolerated. The follow-up ranged from 3 to 80 months (164 and 90 patients completed 2 and 3 years follow-up, respectively). Four patients (1.3%) had local recurrence. The Kaplan-Meier estimate of local recurrence is 2.6% (SE = 1.7) at 5 years. This compares favorably with the 4.3% recurrence rate in boosted patients from the EORTC boost study, in which only 8.1% patients were node-positive, as opposed to 29% in our series.Conclusion: Targeted intraoperative radiotherapy combined with EBRT results in a low local recurrence rate. This could be attributed to both accurate targeting and timeliness of the treatment. These data support the need for a randomized trial to test whether the TARGIT boost is superior to conventional external boost, especially in high-risk women. (c) 2006 Elsevier Inc.",
    doi = "10.1016/j.ijrobp.2006.07.1378",
    issn = "0360-3016",
    issue = "5",
    keyword = "breast cancer",
    keyword = "targeted intraoperative radiotherapy (TARGIT)",
    keyword = "boost",
    keyword = "recurrence rate",
    keyword = "breast-conserving surgery",
    keyword = "EARLY BREAST-CANCER",
    keyword = "BRACHYTHERAPY",
    keyword = "RADIATION",
    language = "EN",
    day = "1",
    }

  • Vaidya, J. (2006) An alternative model of cancer cell growth and metastasis. IN International Journal of Surgery, 5.73-75. doi:10.1016/j.ijsu.2006.06.003
    [BibTeX] [Abstract] [Download PDF]

    Abstract I propose an alternative model of cancer in which metastasis need not all arise out of spread from the “original” tumour. The model assumes that cancer cells arise from stem cells that best grow in the organ of their differentiation. When the internal milieu allows it they also grow at other sites as well, thus complementing the conventional (spreading) metastatic process. Several phenomena in the natural history of cancer, especially breast cancer, that challenge the conventional model, fit well after inclusion of the new model. These are (a) a very modest benefit of screening (b) frequent sparing of lungs from haematogenous metastasis (c) presence of occult cancers in autopsy studies (d) only a modest effect of local treatment (e) relative ineffectiveness of high-dose chemotherapy (f) constant time between surgery and peak of hazard of relapse irrespective of stage of the tumour. All these phenomena are much easier to explain when one rejects the dogma that all metastasis arise only from the primary tumour. This paper is aimed only to suggest an alternative perspective of natural history of solid tumours – to stimulate research on the complex internal milieu that allows cancer cells to develop in new light.

    @article{vaidya2006anmetastasis,
    author = "Vaidya, JS",
    journal = "International Journal of Surgery",
    month = "Jul",
    pages = "73--75",
    title = "An alternative model of cancer cell growth and metastasis",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17448967",
    volume = "5",
    year = "2006",
    abstract = "Abstract
    I propose an alternative model of cancer in which metastasis need not all arise out of spread from the “original” tumour. The model assumes that cancer cells arise from stem cells that best grow in the organ of their differentiation. When the internal milieu allows it they also grow at other sites as well, thus complementing the conventional (spreading) metastatic process. Several phenomena in the natural history of cancer, especially breast cancer, that challenge the conventional model, fit well after inclusion of the new model. These are (a) a very modest benefit of screening (b) frequent sparing of lungs from haematogenous metastasis (c) presence of occult cancers in autopsy studies (d) only a modest effect of local treatment (e) relative ineffectiveness of high-dose chemotherapy (f) constant time between surgery and peak of hazard of relapse irrespective of stage of the tumour. All these phenomena are much easier to explain when one rejects the dogma that all metastasis arise only from the primary tumour. This paper is aimed only to suggest an alternative perspective of natural history of solid tumours – to stimulate research on the complex internal milieu that allows cancer cells to develop in new light.",
    doi = "10.1016/j.ijsu.2006.06.003",
    issn = "1743-9191",
    issue = "2",
    keyword = "model",
    keyword = "alternative",
    keyword = "hypothesis",
    keyword = "natural history",
    keyword = "cancer",
    day = "14",
    }

  • Vaidya, J., Walton, L. & Dewar, J. (2006) Single dose targeted intraoperative radiotherapy (TARGIT) for breast cancer can be delivered as a second procedure under local anaesthetic. IN World Journal of Surgical Oncology, 4.2. doi:10.1186/1477-7819-4-2
    [BibTeX] [Download PDF]
    @article{vaidya2006singleanaesthetic,
    author = "Vaidya, JS and Walton, L and Dewar, J",
    journal = "World Journal of Surgical Oncology",
    month = "Jan",
    pages = "2",
    title = "Single dose targeted intraoperative radiotherapy (TARGIT) for breast cancer can be delivered as a second procedure under local anaesthetic",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/16417631",
    volume = "4",
    year = "2006",
    doi = "10.1186/1477-7819-4-2",
    issn = "1477-7819",
    keyword = "Targit",
    keyword = "Intraoperative radiotherapy",
    keyword = "IORT",
    keyword = "radiation therapy",
    keyword = "local anaesthetic",
    day = "17",
    }

  • Vaidya, J. (2006) Intraoperative Radiotherapy: a Precise Approach for Partial Breast Irradiation. IN Wazer, D., Arthur, D. & Vicini, A. (Eds.), Accelerated Partial Breast Irradiation: Techniques and Clinical Implementation.. doi:10.1007/3-540-28203-3
    [BibTeX]
    @incollection{vaidya2006intraoperativeradiotherapy:irradiation,
    author = "Vaidya, JS",
    booktitle = "Accelerated Partial Breast Irradiation: Techniques and Clinical Implementation",
    editor = "Wazer, D and Arthur, D and Vicini, A",
    number = "12",
    pages = "163--178",
    publisher = "Springer",
    title = "Intraoperative
    Radiotherapy: a Precise Approach for Partial Breast Irradiation",
    year = "2006",
    doi = "10.1007/3-540-28203-3",
    isbn = "978-3-540-28202-0",
    }

  • Keshtgar, M., Tobias, J., Vaidya, J. & et , A. (2006) Use of intra-operative radiotherapy [IORT] alone in breast cancer patients when conventional external beam radiation therapy [EBRT] was not possible , S86.
    [BibTeX]
    @inproceedings{keshtgar2006usepossible,
    author = "Keshtgar, M and Tobias, J and Vaidya, JS and et, A",
    booktitle = "Eur J Surg Oncol",
    pages = "S86",
    title = "Use of intra-operative radiotherapy [IORT] alone in breast cancer patients when conventional external beam radiation therapy [EBRT] was not possible",
    volume = "32",
    year = "2006",
    issue = "Supplement 1",
    }

  • Enderling, H., Chaplain, M., Anderson, S., Munro, A. & Vaidya, J. (2006) Mathematical modelling of radiotherapy strategies for early breast cancer. IN Journal of Theoretical Biology, 241.158-171. doi:10.1016/j.jtbi.2005.11.015
    [BibTeX]
    @article{enderling2006mathematicalcancer,
    author = "Enderling, H and Chaplain, MAJ and Anderson, S and Munro, AJ and Vaidya, JS",
    journal = "Journal of Theoretical Biology",
    pages = "158--171",
    title = "Mathematical modelling of radiotherapy strategies for early breast cancer",
    volume = "241",
    year = "2006",
    doi = "10.1016/j.jtbi.2005.11.015",
    issn = "0022-5193",
    issue = "1",
    }

  • Vaidya, J., Baum, M., Tobias, J., Massarut, S., Wenz, F., Murphy, O., Hilaris, B., Houghton, J., Saunders, C., Corica, T., Roncadin, M., Kraus-Tiefenbacher, U., Melchaert, F., Keshtgar, M., Sainsbury, R., Douek, M., Harrison, E., Thompson, A. & Joseph, D. (2006) Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost.. IN International Journal of Radiation Oncology Biology Physics, 66.1335-1338. doi:10.1016/j.ijrobp.2006.07.1378
    [BibTeX] [Abstract] [Download PDF]

    Purpose: Patients undergoing breast-conserving surgery were offered boost radiotherapy with targeted intraoperative radiotherapy (TARGIT) using the Intrabeam system to test the feasibility, safety, and efficacy of the new approach. Methods and Materials: We treated 302 cancers in 301 unselected patients. This was not a low-risk group. One-third of patients (98/301) were younger than 51 years of age. More than half of the tumors (172, 57%) were between 1 cm and 2 cm, and one-fifth (62, 21%) were > 2 cm; 29% (86) had a Grade 3 tumor and, in 29% (87), axillary lymph nodes contained metastasis. After primary surgery, 20 Gy was delivered intraoperatively to the surface of the tumor bed, followed by external-beam radiotherapy (EBRT), but excluding the usual boost. Results: The treatment was well tolerated. The follow-up ranged from 3 to 80 months (164 and 90 patients completed 2 and 3 years follow-up, respectively). Four patients (1.3%) had local recurrence. The Kaplan-Meier estimate of local recurrence is 2.6% (SE = 1.7) at 5 years. This compares favorably with the 4.3% recurrence rate in boosted patients from the EORTC boost study, in which only 8.1% patients were node-positive, as opposed to 29% in our series. Conclusion: Targeted intraoperative radiotherapy combined with EBRT results in a low local recurrence rate. This could be attributed to both accurate targeting and timeliness of the treatment. These data support the need for a randomized trial to test whether the TARGIT boost is superior to conventional external boost, especially in high-risk women

    @article{vaidya2006targetedboost.,
    address = "j.s.vaidya@dundee.ac.uk",
    author = "Vaidya, JS and Baum, M and Tobias, JS and Massarut, S and Wenz, F and Murphy, O and Hilaris, B and Houghton, J and Saunders, C and Corica, T and Roncadin, M and Kraus-Tiefenbacher, U and Melchaert, F and Keshtgar, M and Sainsbury, R and Douek, M and Harrison, E and Thompson, A and Joseph, D",
    journal = "International Journal of Radiation Oncology Biology Physics",
    pages = "1335--1338",
    publisher = "ELSEVIER SCIENCE INC",
    title = "Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17084562",
    volume = "66",
    year = "2006",
    abstract = "Purpose: Patients undergoing breast-conserving surgery were offered boost radiotherapy with targeted intraoperative radiotherapy (TARGIT) using the Intrabeam system to test the feasibility, safety, and efficacy of the new approach.
    Methods and Materials: We treated 302 cancers in 301 unselected patients. This was not a low-risk group. One-third of patients (98/301) were younger than 51 years of age. More than half of the tumors (172, 57%) were between 1 cm and 2 cm, and one-fifth (62, 21%) were > 2 cm; 29% (86) had a Grade 3 tumor and, in 29% (87), axillary lymph nodes contained metastasis. After primary surgery, 20 Gy was delivered intraoperatively to the surface of the tumor bed, followed by external-beam radiotherapy (EBRT), but excluding the usual boost.
    Results: The treatment was well tolerated. The follow-up ranged from 3 to 80 months (164 and 90 patients completed 2 and 3 years follow-up, respectively). Four patients (1.3%) had local recurrence. The Kaplan-Meier estimate of local recurrence is 2.6% (SE = 1.7) at 5 years. This compares favorably with the 4.3% recurrence rate in boosted patients from the EORTC boost study, in which only 8.1% patients were node-positive, as opposed to 29% in our series.
    Conclusion: Targeted intraoperative radiotherapy combined with EBRT results in a low local recurrence rate. This could be attributed to both accurate targeting and timeliness of the treatment. These data support the need for a randomized trial to test whether the TARGIT boost is superior to conventional external boost, especially in high-risk women",
    doi = "10.1016/j.ijrobp.2006.07.1378",
    issn = "0360-3016",
    issue = "5",
    keyword = "Targit",
    keyword = "Intraoperative radiotherapy",
    keyword = "IORT",
    keyword = "boost",
    keyword = "radiation therapy",
    keyword = "TARGIT",
    keyword = "targeted intraoperative radiotherapy",
    keyword = "radiotherapy",
    keyword = "recurrence",
    }

  • Vaidya, J. (2006) Intraoperative radiotherapy for breast cancer. .
    [BibTeX]
    @article{vaidya2006intraoperativecancer,
    author = "Vaidya, JS",
    journal = "",
    publisher = "Springer",
    school = "Boston",
    series = "Accelerated Partial Breast Irradiation",
    title = "Intraoperative radiotherapy for breast cancer",
    year = "2006",
    }

  • Massarut, S., Belletti, B., Vaidya, J., D Andrea, S., Roncadin, M., Candiani, E., Reccanello, S., Perin, T., Colombatti, A. & Baldassarre, G. (2006) Targeted intraoperative radiotherapy abrogates the stimulatory effect of breast surgical wound fluid on cancer cell motility and invasion , 10611.
    [BibTeX]
    @inproceedings{massarut2006targetedinvasion,
    author = "Massarut, S and Belletti, B and Vaidya, JS and D Andrea, S and Roncadin, M and Candiani, E and Reccanello, S and Perin, T and Colombatti, A and Baldassarre, G",
    booktitle = "Journal of Clinical Oncology",
    pages = "10611",
    title = "Targeted intraoperative radiotherapy abrogates the stimulatory effect of breast surgical wound fluid on cancer cell motility and invasion",
    volume = "24",
    year = "2006",
    issue = "18S",
    }

  • Vaidya, J. & Massarut, S. (2006) Recent advances in Surgery -28. IN The Surgeon, 4.119.
    [BibTeX]
    @article{vaidya2006recent-28,
    author = "Vaidya, JS and Massarut, S",
    journal = "The Surgeon",
    pages = "119",
    title = "Recent advances in Surgery -28",
    volume = "4",
    year = "2006",
    issue = "2",
    }

  • Vaidya, J. (2006) In favour of partial breast irradiation in selected patients and a well directed intraoperative boost. IN The Breast, 15.581-583. doi:10.1016/j.breast.2006.06.001
    [BibTeX]
    @article{vaidya2006inboost,
    author = "Vaidya, JS",
    journal = "The Breast",
    pages = "581--583",
    title = "In favour of partial breast irradiation in selected patients and a well directed intraoperative boost",
    volume = "15",
    year = "2006",
    doi = "10.1016/j.breast.2006.06.001",
    issn = "0960-9776",
    issue = "5",
    }

  • Kraus-Tiefenbacher, U., Bauer, L., Vaidya, J., Baum, M., Tobias, J., Murphy, O., Joseph, D., Hilaris, B., Massarut, S., Melchert, F. & Wenz, F. (2006) Intraoperative radiotherapy (IORT) as a boost in patients with breast cancer , 26-27.
    [BibTeX]
    @inproceedings{kraus-tiefenbacher2006intraoperativecancer,
    author = "Kraus-Tiefenbacher, U and Bauer, L and Vaidya, J and Baum, M and Tobias, J and Murphy, O and Joseph, D and Hilaris, B and Massarut, S and Melchert, F and Wenz, F",
    booktitle = "Strahlentherapie Und Onkologie",
    pages = "26--27",
    title = "Intraoperative radiotherapy (IORT) as a boost in patients with breast cancer",
    volume = "182",
    year = "2006",
    issue = "Suppl",
    }

  • Tobias, J., Keshtgar, M., Douek, M., Vaidya, J., Stacey, C., Metaxas, M., Sainsbury, R. & Baum, M. (2006) Breast conserving surgery with intra-operative radiotherapy: The right approach for the 21st century? IN Drinkovic, I. (Ed.), . UCL Hosp, Middlesex Hosp, Meyerstein Inst Oncol, London W1T 3AA, England, MEDIMOND S R L, 97-103.
    [BibTeX]
    @inproceedings{tobias2006breastcentury?,
    address = "UCL Hosp, Middlesex Hosp, Meyerstein Inst Oncol, London W1T 3AA, England",
    author = "Tobias, JS and Keshtgar, M and Douek, M and Vaidya, JS and Stacey, C and Metaxas, M and Sainsbury, R and Baum, M",
    booktitle = "Proceedings of the XIV World Congress on Breast Diseases",
    editor = "Drinkovic, I",
    organization = "Zagreb, CROATIA",
    pages = "97--103",
    publisher = "MEDIMOND S R L",
    title = "Breast conserving surgery with intra-operative radiotherapy: The right approach for the 21st century?",
    year = "2006",
    startyear = "2006",
    startmonth = "May",
    startday = "18",
    finishyear = "2006",
    finishmonth = "May",
    finishday = "21",
    isbn = "88-7587-292-9",
    keyword = "CANCER PATIENTS",
    keyword = "TARGIT",
    keyword = "BRACHYTHERAPY",
    keyword = "LUMPECTOMY",
    keyword = "RADIATION",
    keyword = "TRIAL",
    keyword = "TUMOR",
    language = "EN",
    conference = "14th World Congress on Breast Diseases",
    }

  • Vaidya, J., Baum, M., Tobias, J. & et , A. (2006) A very low recurrence rate is achieved by a targeted intraoperative radiotherapy (TARGIT) boost after breast conserving surgery for cancer , S86.
    [BibTeX]
    @inproceedings{vaidya2006acancer,
    author = "Vaidya, JS and Baum, M and Tobias, JS and et, A",
    booktitle = "Eur J Surg Oncol",
    pages = "S86",
    title = "A very low recurrence rate is achieved by a targeted intraoperative radiotherapy (TARGIT) boost after breast conserving surgery for cancer",
    volume = "32",
    year = "2006",
    issue = "Supplement 1",
    }

  • Tobias, J., Vaidya, J., Keshtgar, M., Douek, M., Metaxas, M., Stacey, C., Sainsbury, R., D ‘Souza, D. & Baum, M. (2006) Breast-conserving surgery with intra-operative radiotherapy:the right approach for the 21st century?. IN Clinical Oncology, 18.220-228. doi:10.1016/j.clon.2005.11.017
    [BibTeX] [Download PDF]
    @article{tobias2006breast-conservingcentury?,
    address = "j.s.vaidya@dundee.ac.uk",
    author = "Tobias, JS and Vaidya, JS and Keshtgar, M and Douek, M and Metaxas, M and Stacey, C and Sainsbury, R and D 'Souza, D and Baum, M",
    journal = "Clinical Oncology",
    pages = "220--228",
    title = "Breast-conserving surgery with intra-operative radiotherapy:the right approach for the 21st century?",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/16605053",
    volume = "18",
    year = "2006",
    doi = "10.1016/j.clon.2005.11.017",
    issn = "0936-6555",
    issue = "3",
    keyword = "breast",
    keyword = "breast cancer",
    keyword = "breast conserving surgery",
    keyword = "intraoperative",
    keyword = "intra-operative",
    }

  • Vaidya, J., Kocabayoglu, P., McLean, D. & Jordan, L. (2006) Eyes do not see what the mind does not know – a desmoid tumour in the breast. IN International Journal of Surgery, ..
    [BibTeX] [Download PDF]
    @article{vaidya2006eyesbreast,
    author = "Vaidya, JS and Kocabayoglu, P and McLean, D and Jordan, L",
    journal = "International Journal of Surgery",
    title = "Eyes do not see what the mind does not know – a desmoid tumour in the breast",
    url = "http://linkinghub.elsevier.com/retrieve/pii/S1743919106001233",
    year = "2006",
    issn = "1743-9191",
    }

  • Vaidya, J. (2005) V-index: A fairer index to quantify an individual ‘s research output capacity. IN BMJ, ..
    [BibTeX] [Download PDF]
    @article{vaidya2005v-index:capacity,
    author = "Vaidya, JS",
    journal = "BMJ",
    month = "Dec",
    title = "V-index: A fairer index to quantify an individual 's research output capacity",
    url = "http://bmj.com/cgi/eletters/331/7528/1339-c#123188",
    year = "2005",
    issn = "0959-8138",
    day = "6",
    }

  • Vaidya, J. (2005) Does screening mammography cause cancers?. IN BMJ, ..
    [BibTeX] [Download PDF]
    @article{vaidya2005doescancers?,
    author = "Vaidya, JS",
    journal = "BMJ",
    month = "May",
    title = "Does screening mammography cause cancers?",
    url = "http://bmj.bmjjournals.com/cgi/eletters/330/7497/936#106627",
    year = "2005",
    issn = "0959-8138",
    day = "16",
    }

  • Vaidya, J. (2005) Therapy of breast diseases: experts’ overview. IN Breast Cancer Research, 7.59-60.
    [BibTeX]
    @article{vaidya2005therapyoverview,
    author = "Vaidya, JS",
    journal = "Breast Cancer Research",
    month = "Jan",
    pages = "59--60",
    title = "Therapy of breast diseases: experts’ overview",
    volume = "7",
    year = "2005",
    issn = "1465-5411",
    day = "26",
    }

  • Vaidya, J., Baum, M., Tobias, J., Wenz, F., Massarut, S., Hilaris, B., Houghton, J., Murphy, O., Saunders, C., Corica, T., Harrison, E., Keshtgar, M., Douek, M., Sainsbury, R., Kraus-Tiefenbacher, U., Melchart, F. & Joseph, D. (2005) Targeted intraoperative radiotherapy (TARGIT) as a boost yields very low recurrence rates. Univ Dundee, Dundee, Scotland and Ninewells Hosp, Dundee DD1 9SY, Scotland and UCL, London WC1E 6BT, England and Univ Mannheim, Mannheim, Germany and CRO, Aviano, Italy and Sir Charles Gairdner Hosp, Perth, WA, Australia and Our Lady Mercy New York Med Coll, New York, NY USA, SPRINGER, S180–S180.
    [BibTeX]
    @inproceedings{vaidya2005targetedrates.,
    address = "Univ Dundee, Dundee, Scotland and Ninewells Hosp, Dundee DD1 9SY, Scotland and UCL, London WC1E 6BT, England and Univ Mannheim, Mannheim, Germany and CRO, Aviano, Italy and Sir Charles Gairdner Hosp, Perth, WA, Australia and Our Lady Mercy New York Med Coll, New York, NY USA",
    author = "Vaidya, JS and Baum, M and Tobias, JS and Wenz, F and Massarut, S and Hilaris, BS and Houghton, J and Murphy, O and Saunders, C and Corica, T and Harrison, E and Keshtgar, M and Douek, M and Sainsbury, R and Kraus-Tiefenbacher, U and Melchart, F and Joseph, D",
    booktitle = "BREAST CANCER RESEARCH AND TREATMENT",
    month = "Jan",
    organization = "San Antonio, TX",
    pages = "S180--S180",
    publisher = "SPRINGER",
    title = "Targeted intraoperative radiotherapy (TARGIT) as a boost yields very low recurrence rates.",
    volume = "94",
    year = "2005",
    startyear = "2005",
    startmonth = "Dec",
    startday = "8",
    finishyear = "2005",
    finishmonth = "Dec",
    finishday = "11",
    issn = "0167-6806",
    language = "EN",
    conference = "28th Annual San Antonio Breast Cancer Symposium",
    }

  • Vaidya, J., Tobias, J., Baum, M., Wenz, F., Kraus-Tiefenbacher, U., D’Souza, D., Keshtgar, M., Massarut, S., Hilaris, B., Saunders, C. & Joseph, D. (2005) TARGeted Intraoperative radiotherapy(TARGIT):an innovative approach to partial-breast irradiation. IN Seminars in Radiation Oncology, 15.84-91.
    [BibTeX] [Download PDF]
    @article{vaidya2005targetedirradiation,
    author = "Vaidya, JS and Tobias, JS and Baum, M and Wenz, F and Kraus-Tiefenbacher, U and D'Souza, D and Keshtgar, M and Massarut, S and Hilaris, B and Saunders, C and Joseph, D",
    journal = "Seminars in Radiation Oncology",
    pages = "84--91",
    title = "TARGeted Intraoperative radiotherapy(TARGIT):an innovative approach to partial-breast irradiation",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/15809933",
    volume = "15",
    year = "2005",
    issn = "1053-4296",
    issue = "2",
    }

  • Enderling, H., Chaplain, M., Anderson, S., Munro, A. & Vaidya, J. (2005) Mathematical modelling of radiotherapy strategies for early breast cancer. IN Journal of Theoretical Biology, 241.158-171. doi:10.1016/j.jtbi.2005.11.015
    [BibTeX] [Download PDF]
    @article{enderling2005mathematicalcancer,
    author = "Enderling, H and Chaplain, MAJ and Anderson, S and Munro, AJ and Vaidya, JS",
    journal = "Journal of Theoretical Biology",
    pages = "158--171",
    title = "Mathematical modelling of radiotherapy strategies for early breast cancer",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/16386275",
    volume = "241",
    year = "2005",
    doi = "10.1016/j.jtbi.2005.11.015",
    issn = "0022-5193",
    issue = "1",
    keyword = "Targit",
    keyword = "Intraoperative radiotherapy",
    keyword = "mathematical modelling",
    keyword = "radiation therapy",
    }

  • Vaidya, J. (2005) Screening for disease – The good – The bad and the thoughtful.. IN International Journal of Surgery, 3.107-112.
    [BibTeX] [Download PDF]
    @article{vaidya2005screeningthoughtful.,
    author = "Vaidya, JS",
    journal = "International Journal of Surgery",
    note = "Epub 2005 Aug 18",
    pages = "107--112",
    publisher = "Elsevier",
    title = "Screening for disease - The good - The bad and the thoughtful.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/17462269",
    volume = "3",
    year = "2005",
    issn = "1743-9191",
    issue = "2",
    keyword = "screening mammography",
    keyword = "screening for disease",
    keyword = "natural history of cancer",
    }

  • Vaidya, J., Dewar, J., Brown, D. & Thompson, A. (2005) A mathematical model for the effect of false negative rate of sentinel node biopsy on breast cancer mortality – a tool for everyday use.. IN Breast Cancer Research, .225-227.
    [BibTeX] [Download PDF]
    @article{vaidya2005ause.,
    author = "Vaidya, JS and Dewar, JA and Brown, DC and Thompson, AM",
    journal = "Breast Cancer Research",
    pages = "225--227",
    title = "A mathematical model for the effect of false negative rate of sentinel node biopsy on breast cancer mortality - a tool for everyday use.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/16168143",
    year = "2005",
    issn = "1465-5411",
    issue = "7",
    keyword = "SNB",
    keyword = "sentinel node biopsy",
    keyword = "mathematical model",
    keyword = "risk",
    keyword = "benefit",
    keyword = "early breast cancer",
    }

  • Vaidya, J., Wilson, A. & Choudhury, R. (2004) Orientation of a breast specimen with radio-opaque thread – A novel solution. IN European Journal of Surgical Oncology, 30.460-461. doi:10.1016/j.ejso.2004.01.008
    [BibTeX]
    @article{vaidya2004orientationsolution,
    author = "Vaidya, JS and Wilson, AJ and Choudhury, R",
    journal = "European Journal of Surgical Oncology",
    month = "May",
    pages = "460--461",
    title = "Orientation of a breast specimen with radio-opaque thread - A novel solution",
    volume = "30",
    year = "2004",
    doi = "10.1016/j.ejso.2004.01.008",
    issn = "0748-7983",
    issue = "4",
    }

  • Vaidya, J., Wilson, A. & Choudhary, R. (2004) Orientation of a breast specimen with radio-opaque thread – A novel solution. IN European Journal of Surgical Oncology, 30.460-461.
    [BibTeX] [Download PDF]
    @article{vaidya2004orientationsolution,
    author = "Vaidya, JS and Wilson, A and Choudhary, R",
    journal = "European Journal of Surgical Oncology",
    pages = "460--461",
    title = "Orientation of a breast specimen with radio-opaque thread - A novel solution",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/15063903",
    volume = "30",
    year = "2004",
    issn = "0748-7983",
    keyword = "Needle",
    keyword = "Localisation",
    keyword = "Biopsy",
    keyword = "Orientation",
    keyword = "Novel Technique",
    }

  • Vaidya HJ c/o Vaidya, J. (2004) Playstation Thumb. IN The Lancet, 363.1080.
    [BibTeX] [Download PDF]
    @article{vaidya2004playstationthumb,
    author = "Vaidya, HJ c/o Vaidya, JS",
    journal = "The Lancet",
    pages = "1080",
    title = "Playstation Thumb",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/15051306",
    volume = "363",
    year = "2004",
    issn = "0140-6736",
    issue = "9414",
    keyword = "Friction",
    keyword = "Injury",
    keyword = "Child",
    keyword = "Games Console",
    keyword = "Playstation",
    }

  • Vaidya, J., Tobias, J., Baum, M., Keshtgar, M., Houghton, J., Wenz, F., Corica, T. & Joseph, D. (2004) Intraoperative radiotherapy: The debate continues. IN The Lancet Oncology, 5.339-340. doi:10.1016/S1470-2045(04)01488-3
    [BibTeX] [Download PDF]
    @article{vaidya2004intraoperativecontinues,
    author = "Vaidya, JS and Tobias, J and Baum, M and Keshtgar, M and Houghton, J and Wenz, F and Corica, T and Joseph, D",
    journal = "The Lancet Oncology",
    pages = "339--340",
    title = "Intraoperative radiotherapy: The debate continues",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/15172352",
    volume = "5",
    year = "2004",
    doi = "10.1016/S1470-2045(04)01488-3",
    issn = "1470-2045",
    issue = "6",
    keyword = "Debate",
    keyword = "Intraoperative",
    keyword = "Radiotherapy",
    keyword = "Randomised",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Breast Cancer",
    keyword = "Clinical Trials",
    keyword = "TARGIT Trial",
    keyword = "intraoperative",
    keyword = "intra-operative",
    keyword = "radiotherapy",
    keyword = "debate",
    keyword = "breast",
    keyword = "breast cancer",
    }

  • Vaidya, J., Tobias, J., Baum, M., Keshtgar, M., Joseph, D., Wenz, F., Houghton, J., Saunders, C., Corica, T., D’Souza, D., Sainsbury, R., Massarut, S., Taylor, I. & Hilaris, B. (2004) Intraoperative radiotherapy for breast cancer. IN The Lancet Oncology, 5.165-173. doi:10.1016/S1470-2045(04)01412-3
    [BibTeX] [Abstract]

    Postoperative radiotherapy, which forms part of breast- conserving therapy, may not need to encompass the whole breast. Apart from the consumption of huge resources and patients\\’ time, postoperative radiotherapy deters many women from receiving the benefits of breast-conserving surgery, forcing them to choose a mastectomy instead. If radiotherapy could be given in the operating theatre immediately after surgery, many of these disadvantages could be overcome. One striking fact about local recurrence after breast-conserving surgery is that most occurs in the area of breast immediately next to the primary tumour; this is despite the finding that two-thirds of mastectomy samples have microscopic tumours distributed throughout the breast, even when radiotherapy is omitted. Thus, only the area adjacent to the tumour may need treatment with radiotherapy. On the basis of this premise, clinical scientists have used new technology to administer radiotherapy to the area at greatest risk of local recurrence, with the aim of completing the whole local treatment in one sifting. In this review, we have elaborated on the rationale and different methods of delivery of intraoperative radiotherapy. If this approach is validated by the results of current randomised trials, it could save time, money, and breasts

    @article{vaidya2004intraoperativecancer,
    author = "Vaidya, JS and Tobias, JS and Baum, M and Keshtgar, M and Joseph, D and Wenz, F and Houghton, J and Saunders, C and Corica, T and D'Souza, D and Sainsbury, R and Massarut, S and Taylor, I and Hilaris, B",
    journal = "The Lancet Oncology",
    note = "WoS ID: 000220167200019
    JournalEnglishReview51LANCET LTDARRIAGADA R, 2002, ANN ONCOL, V13, P1404; ASTOR MB, 2000, INT J RADIAT ONCOL, V47, P809; ATHAS WF, 2000, J NATL CANCER I, V92, P269; BARTELINK H, 2001, NEW ENGL J MED, V345, P1378; BOYAGES J, 1990, RADIOTHER ONCOL, V19, P29; BRENNER DJ, 1999, PHYS MED BIOL, V44, P323; CHAN DY, 2000, J ENDOUROL, V14, P111; CLARK RM, 1982, INT J RADIAT ONCOL, V8, P967; CLARK RM, 1996, J NATL CANCER I, V88, P1659; CLARK RM, 1992, J NATL CANCER I, V84, P683; DENG GR, 1996, SCIENCE, V274, P2057; FISHER B, 1995, NEW ENGL J MED, V333, P1456; FISHER ER, 1992, SEMIN SURG ONCOL, V8, P161; FORREST AP, 1996, LANCET, V348, P708; HARROLD EV, 1998, CANCER J SCI AM, V4, P302; INTRA M, 2002, ARCH SURG-CHICAGO, V137, P737; JOHANSSON B, 2000, P 10 INT BRACH C MAD, P127; KING TA, 2000, AM J SURG, V180, P299; KONIARIS LG, 2000, J AM COLL SURGEONS, V191, P164; KRISHNAN L, 2001, BREAST J, V7, P91; KURITA H, 2000, MINIM INVAS NEUROSUR, V43, P197; KURTZ JM, 1989, CANCER, V63, P1912; LILJEGREN G, 1999, J CLIN ONCOL, V17, P2326; LU Q, 1996, ENDOCRINOLOGY, V137, P3061; MACHTAY M, 1994, INT J RADIAT ONCOL, V30, P43; MCCULLOCH PG, 1993, BRIT J SURG, V80, P1005; NAKAMURA J, 1996, ENDOCRINOLOGY, V137, P5589; NIELSEN M, 1987, BRIT J CANCER, V56, P814; ONEILL JS, 1988, BRIT MED J, V296, P741; PERERA F, 1997, J SURG ONCOL, V65, P263; POLGAR C, 2002, J SURG ONCOL, V80, P121; POLGAR C, 2002, STRAHLENTHER ONKOL, V178, P597; RIBEIRO GG, 1993, CLIN ONCOL, V5, P278; SAMUEL LM, 1999, BREAST, V8, P95; SCHNITT SJ, 1984, CANCER, V53, P1049; SEDLMAYER F, 1996, INT J RADIAT ONCOL, V34, P1133; SOLOMON SB, 2001, J COMPUT ASSIST TOMO, V25, P74; TURNER BC, 2000, CANCER, V88, P1091; TURNER BC, 1999, J CLIN ONCOL, V17, P3017; VAIDYA JS, 2001, ANN ONCOL, V12, P1075; VAIDYA JS, 2003, BREAST CANC RES T S1, V82, P1039; VAIDYA JS, 1996, BRIT J CANCER, V74, P820; VAIDYA JS, 2002, EUR J SURG ONCOL, V28, P447; VAIDYA JS, 2002, LANCET ONCOL, V3, P252; VAIDYA JS, 2002, P 21 EUR SOC THER RA, V21; VAIDYA JS, PROTOCOL 99PRT47 TAR; VAIDYA JS, 2002, THESIS U LONDON; VERONESI U, 2001, EUR J CANCER, V37, P2178; VERONESI U, 1993, NEW ENGL J MED, V328, P1587; VICINI FA, 2001, J CLIN ONCOL, V19, P1993; WAZER DE, 2001, INT J RADIAT ONCOL, V50, P10712MAR802MILONDONVaidya JS Royal Free \\& Univ Coll Med Sch, Dept Surg, Clin Trials Grp, Charles Bell House,67-73 Riding House St, London W1W 7EJ, EnglandLANCET ONCOL84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND",
    pages = "165--173",
    title = "Intraoperative radiotherapy for breast cancer",
    volume = "5",
    year = "2004",
    abstract = "Postoperative radiotherapy, which forms part of breast- conserving therapy, may not need to encompass the whole breast. Apart from the consumption of huge resources and patients\\' time, postoperative radiotherapy deters many women from receiving the benefits of breast-conserving surgery, forcing them to choose a mastectomy instead. If radiotherapy could be given in the operating theatre immediately after surgery, many of these disadvantages could be overcome. One striking fact about local recurrence after breast-conserving surgery is that most occurs in the area of breast immediately next to the primary tumour; this is despite the finding that two-thirds of mastectomy samples have microscopic tumours distributed throughout the breast, even when radiotherapy is omitted. Thus, only the area adjacent to the tumour may need treatment with radiotherapy. On the basis of this premise, clinical scientists have used new technology to administer radiotherapy to the area at greatest risk of local recurrence, with the aim of completing the whole local treatment in one sifting. In this review, we have elaborated on the rationale and different methods of delivery of intraoperative radiotherapy. If this approach is validated by the results of current randomised trials, it could save time, money, and breasts",
    doi = "10.1016/S1470-2045(04)01412-3",
    issn = "1470-2045",
    issue = "3",
    keyword = "Benefits",
    keyword = "Breast",
    keyword = "Breast cancer",
    keyword = "Breast Conserving surgery",
    keyword = "Breast Neoplasms",
    keyword = "Breast-Cancer",
    keyword = "Breast-Conserving",
    keyword = "Breast-Conserving Surgery",
    keyword = "cancer",
    keyword = "Clinical",
    keyword = "Clinical Trial",
    keyword = "Clinical Trials",
    keyword = "Clinical-Trial",
    keyword = "Delivery",
    keyword = "Female",
    keyword = "Humans",
    keyword = "instrumentation",
    keyword = "Intraoperative",
    keyword = "Intraoperative Care",
    keyword = "Local recurrence",
    keyword = "Mastectomies",
    keyword = "Mastectomy",
    keyword = "Neoplasm Recurrence",
    keyword = "Local",
    keyword = "New Technologies",
    keyword = "Patient",
    keyword = "Patient Acceptance of Health Care",
    keyword = "Patients",
    keyword = "Postoperative",
    keyword = "prevention \\& control",
    keyword = "Radiotherapy",
    keyword = "Randomised",
    keyword = "Randomised Trial",
    keyword = "randomised trials",
    keyword = "Rationale",
    keyword = "Recurrence",
    keyword = "Resource",
    keyword = "Resources",
    keyword = "Surgery",
    keyword = "Technologies",
    keyword = "Technology",
    keyword = "Therapies",
    keyword = "Therapy",
    keyword = "Treatment",
    keyword = "Tumour",
    keyword = "Tumours",
    keyword = "Uk",
    keyword = "Women",
    keyword = "AXILLARY DISSECTION",
    keyword = "breast cancer",
    keyword = "CANCER",
    keyword = "CANINE MODEL",
    keyword = "CONSERVATIVE SURGERY",
    keyword = "CONSERVING SURGERY",
    keyword = "IRRADIATION FOLLOWING LUMPECTOMY",
    keyword = "LOCAL RECURRENCE",
    keyword = "PHOTON RADIATION ENERGY",
    keyword = "POSTOPERATIVE RADIOTHERAPY",
    keyword = "radiotherapy",
    keyword = "RANDOMIZED CLINICAL-TRIAL",
    keyword = "RECURRENCE",
    keyword = "RISK",
    keyword = "STAGE-I",
    keyword = "THERAPY",
    keyword = "TRIAL",
    keyword = "TRIALS",
    keyword = "TUMOR BED",
    keyword = "WOMEN",
    keyword = "breast cancer",
    keyword = "breast",
    keyword = "intra-operative",
    keyword = "intraoperative",
    keyword = "radiotherapy",
    }

  • Vaidya, J. (2004) Therapy of breast diseases: Experts’ overview. IN Breast Cancer Research, 7.59-60.
    [BibTeX]
    @article{vaidya2004therapyoverview,
    author = "Vaidya, JS",
    journal = "Breast Cancer Research",
    pages = "59--60",
    title = "Therapy of breast diseases: Experts' overview",
    volume = "7",
    year = "2004",
    issn = "1465-5411",
    keyword = "Breast Cancer Management",
    }

  • Gray, L., Vaidya, J., Baum, M., Badwe, R., Mittra, I., Siddiqui, T. & Wiarda, D. (2004) Functional maps of metastases from breast cancers: Proof of the principle that multidimensional scaling can summarize disease progression. IN World Journal of Surgery, 28.646-651.
    [BibTeX] [Download PDF]
    @article{gray2004functionalprogression,
    author = "Gray, LC and Vaidya, JS and Baum, M and Badwe, RA and Mittra, I and Siddiqui, T and Wiarda, D",
    journal = "World Journal of Surgery",
    pages = "646--651",
    title = "Functional maps of metastases from breast cancers: Proof of the principle that multidimensional scaling can summarize disease progression",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/15185001",
    volume = "28",
    year = "2004",
    issn = "0364-2313",
    issue = "7",
    keyword = "Mathematical Model",
    keyword = "Breast Cancer",
    keyword = "Multidimensional",
    }

  • Tobias, J., Vaidya, J., Keshtgar, M., D’Souza, D. & Baum, M. (2004) Reducing radiotherapy dose in early breast cancer: the concept of conformal intraoperative brachytherapy. IN British Journal of Radiology, 77.279-284. doi:10.1259/bjr/17186381
    [BibTeX]
    @article{tobias2004reducingbrachytherapy,
    author = "Tobias, JS and Vaidya, JS and Keshtgar, M and D'Souza, DP and Baum, M",
    journal = "British Journal of Radiology",
    note = "WoS ID: 000221127300003
    JournalEnglishEditorial Material30BRITISH INST RADIOLOGY*EARL BREAST CANC, 2000, LANCET, V355, P1757; *EARL BREAST CANC, 1992, LANCET, V339, P1; *ROYAL COLL RAD, 1995, REV COMM ROYAL COLL; ABE O, 1998, LANCET, V352, P930; ATKINS H, 1972, BRIT MED J, V2, P423; BARTELINK H, 2001, NEW ENGL J MED, V345, P1378; BAUM M, 2002, LANCET, V360, P1520; BAUM M, 2002, LANCET, V359, P2131; BAUM M, 1997, LANCET, V349, P208; CLARKE M, 1998, LANCET, V351, P1451; COSGROVE GR, 1997, NEUROSURGERY, V40, P518; DOLECKOVA M, 2001, ISRO 2001; DOUGLAS RM, 1996, INT J RADIAT ONCOL, V36, P443; FALLOWFIELD LJ, 1986, BRIT MED J, V293, P1331; GORMAN C, 2002, TIME MAGAZINE, V159, P46; LIND PARM, 1997, ACTA ONCOL, V36, P509; MEINARDI MT, 2001, J CLIN ONCOL, V19, P2746; ORECCHIA R, 2002, EUR J CANC S3, V30, PS90; RUTQVIST LE, 1990, BRIT J CANCER, V61, P866; TOBIAS JS, 1986, BRIT J RADIOL, V59, P653; VAIDIYA JS, 2003, BREAST CANCER RES S1, V82, PS2; VAIDYA JS, 2001, ANN ONCOL, V12, P1; VAIDYA JS, 2001, BREASR CANC RES TREA, V69, P145; VAIDYA JS, 1996, BRIT J CANCER, V74, P820; VAIDYA JS, 1998, EUR J CANCER, V34, P1143; VAIDYA JS, 2002, EUR J SURG ONCOL, V28, P447; VAIDYA JS, 2002, LANCET ONCOL, V3, P252; VERONESI U, 2002, BREAST, V11, P194; VERONESI U, 2001, EUR J CANCER, V37, P2178; VERONESI U, 2002, EUR J CANCER S3, V38, PS891APR816RPLONDONTobias JS Univ Coll London, Hosp NHS Trust, Meyerstein Inst Oncol, Mortimer St, London WC1E 6BT, EnglandBRIT J RADIOL36 PORTLAND PLACE, LONDON W1N 4AT, ENGLAND",
    pages = "279--284",
    title = "Reducing radiotherapy dose in early breast cancer: the concept of conformal intraoperative brachytherapy",
    volume = "77",
    year = "2004",
    doi = "10.1259/bjr/17186381",
    issn = "0007-1285",
    issue = "916",
    keyword = "Breast",
    keyword = "Intraoperative Radiotherapy",
    keyword = "TARGIT",
    keyword = "IORT",
    keyword = "breast cancer",
    keyword = "CANCER",
    keyword = "CONSERVATION",
    keyword = "IRRADIATION",
    keyword = "MULTICENTRICITY",
    keyword = "RADIATION",
    keyword = "radiotherapy",
    keyword = "RANDOMIZED-TRIALS",
    keyword = "RECURRENCE",
    keyword = "TAMOXIFEN",
    keyword = "TARGIT",
    keyword = "breast",
    keyword = "radiotherapy",
    keyword = "intraoperative radiotherapy",
    keyword = "brachytherapy",
    keyword = "radiotherapy doses",
    }

  • Vaidya, J. (2003) Comment on Ä comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy\".. IN J Clin Anesth, 15.570.
    [BibTeX] [Download PDF]
    @article{vaidya2003commentcholecystectomy.,
    author = "Vaidya, JS",
    journal = "J Clin Anesth",
    month = "Nov",
    organization = "United States",
    pages = "570",
    title = "Comment on \"A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy\".",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/14698374",
    volume = "15",
    year = "2003",
    issn = "0952-8180",
    issue = "7",
    keyword = "Antiemetics",
    keyword = "Cholecystectomy, Laparoscopic",
    keyword = "Droperidol",
    keyword = "Drug Therapy, Combination",
    keyword = "Humans",
    keyword = "Ondansetron",
    keyword = "Postoperative Nausea and Vomiting",
    keyword = "Randomized Controlled Trials as Topic",
    language = "eng",
    pii = "S0952818003001363",
    }

  • Vaidya, J., Lalude, O., Grant, D. & Mukhtar, H. (2003) Gallstone ileus.. IN Lancet, 362.1105. doi:10.1016/S0140-6736(03)14465-0
    [BibTeX] [Download PDF]
    @article{vaidya2003gallstoneileus.,
    author = "Vaidya, JS and Lalude, O and Grant, D and Mukhtar, H",
    journal = "Lancet",
    month = "Oct",
    organization = "England",
    pages = "1105",
    title = "Gallstone ileus.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/14550697",
    volume = "362",
    year = "2003",
    doi = "10.1016/S0140-6736(03)14465-0",
    eissn = "1474-547X",
    issue = "9390",
    keyword = "Aged",
    keyword = "Female",
    keyword = "Gallstones",
    keyword = "Humans",
    keyword = "Ileus",
    keyword = "Treatment Outcome",
    language = "eng",
    pii = "S0140-6736(03)14465-0",
    day = "4",
    }

  • VAIDYA, J., Lalude, O., Grant, D. & Mukhtar, H. (2003) Clinical Picture: Gall Stone Ileus. IN The Lancet, .362-1105.
    [BibTeX]
    @article{vaidya2003clinicalileus,
    author = "VAIDYA, J and Lalude, O and Grant, D and Mukhtar, H",
    journal = "The Lancet",
    month = "Oct",
    pages = "362--1105",
    title = "Clinical Picture: Gall Stone Ileus",
    year = "2003",
    day = "4",
    publicationstatus = "published",
    }

  • Vaidya, J., Critchley, J., Hackshaw, A., Glaser, J., Hedley, A., Lam, T., McGhee, S., Leung, G., Pow, M., Milne, E., Thun, M., Davis, R., McKee, M., Enstrom, J., Kabat, G., Horton, R., Tonks, A. & Smith, R. (2003) Passive smoking (multiple letters). IN British Medical Journal, 327.501-505.
    [BibTeX]
    @article{vaidya2003passiveletters,
    author = "Vaidya, JS and Critchley, J and Hackshaw, A and Glaser, JH and Hedley, AJ and Lam, TH and McGhee, SM and Leung, GM and Pow, M and Milne, E and Thun, MJ and Davis, RM and McKee, M and Enstrom, JE and Kabat, GC and Horton, R and Tonks, A and Smith, R",
    journal = "British Medical Journal",
    month = "Aug",
    pages = "501--505",
    title = "Passive smoking (multiple letters)",
    volume = "327",
    year = "2003",
    issn = "0959-8146",
    issue = "7413",
    day = "30",
    }

  • Hensel, W., Fishbein, M., Kopans, D., Fletcher, S., Vaidya, J., Baum, M., Gøtzsche, P. & Elmore, J. (2003) Mammographic screening for breast cancer [3] (multiple letters). IN New England Journal of Medicine, 349.610-612. doi:10.1056/NEJM200308073490617
    [BibTeX]
    @article{hensel2003mammographicletters,
    author = "Hensel, WA and Fishbein, MJ and Kopans, DB and Fletcher, SW and Vaidya, JS and Baum, M and Gøtzsche, PC and Elmore, JG",
    journal = "New England Journal of Medicine",
    month = "Aug",
    pages = "610--612",
    title = "Mammographic screening for breast cancer [3] (multiple letters)",
    volume = "349",
    year = "2003",
    doi = "10.1056/NEJM200308073490617",
    issn = "0028-4793",
    issue = "6",
    day = "7",
    }

  • Vaidya, J. & Baum, M. (2003) Mammographic screening for breast cancer. IN NEW ENGL J MED, 349.611-611.
    [BibTeX]
    @article{vaidya2003mammographiccancer,
    address = "UCL, London W1W 7EJ, England",
    author = "Vaidya, JS and Baum, M",
    journal = "NEW ENGL J MED",
    month = "Aug",
    pages = "611--611",
    publisher = "MASSACHUSETTS MEDICAL SOC/NEJM",
    title = "Mammographic screening for breast cancer",
    volume = "349",
    year = "2003",
    issn = "0028-4793",
    issue = "6",
    language = "EN",
    day = "7",
    }

  • Vaidya, J. & Baum, M. (2003) Mammographic screening for breast cancer.. IN N Engl J Med, 349.610-612.
    [BibTeX] [Download PDF]
    @article{vaidya2003mammographiccancer.,
    author = "Vaidya, JS and Baum, M",
    journal = "N Engl J Med",
    month = "Aug",
    organization = "United States",
    pages = "610--612",
    title = "Mammographic screening for breast cancer.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/12908462",
    volume = "349",
    year = "2003",
    eissn = "1533-4406",
    issue = "6",
    keyword = "Aged",
    keyword = "Breast Neoplasms",
    keyword = "Data Interpretation, Statistical",
    keyword = "Female",
    keyword = "Humans",
    keyword = "Mammography",
    keyword = "Middle Aged",
    keyword = "Risk",
    language = "eng",
    day = "7",
    }

  • Vaidya, J. (2003) Passive smoking: study was flawed from outset.. IN BMJ, 327.501. doi:10.1136/bmj.327.7413.501
    [BibTeX] [Download PDF]
    @article{vaidya2003passiveoutset.,
    author = "Vaidya, JS",
    journal = "BMJ",
    month = "Aug",
    note = "PMCID: PMC188394",
    organization = "England",
    pages = "501",
    title = "Passive smoking: study was flawed from outset.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/12946977",
    volume = "327",
    year = "2003",
    doi = "10.1136/bmj.327.7413.501",
    eissn = "1756-1833",
    issue = "7413",
    keyword = "Humans",
    keyword = "Retraction of Publication as Topic",
    keyword = "Smoking",
    keyword = "Spouses",
    keyword = "Time Factors",
    keyword = "Tobacco Smoke Pollution",
    language = "eng",
    pii = "327/7413/501",
    day = "30",
    }

  • Vaidya, J., Wilson, A., Houghton, J., Tobias, J., Joseph, D., Wenz, F., Hilaris, B., Massarut, S., Keshtgar, M., Sainsbury, R., Taylor, I., D’Souza, D., Saunders, C., Corica, T., Ezio, C., Mauro, A. & Baum, M. (2003) Cosmetic outcome after targeted intraoperative radiotherapy (targit) for early breast caner. UCL, Middlesex Hosp, London WC1E 6BT, England and UCL, Whittington Hosp, London WC1E 6BT, England and Sir Charles Gairdner Hosp, Perth, WA, Australia and Inst Klin Radiol, Mannheim, Germany and New York Med Coll, Our Lady Mercy New York Ctr, New York, NY USA and Ctr Riferimento Oncol, I-33081 Aviano, Italy, KLUWER ACADEMIC PUBL, S180–S180.
    [BibTeX]
    @inproceedings{vaidya2003cosmeticcaner.,
    address = "UCL, Middlesex Hosp, London WC1E 6BT, England and UCL, Whittington Hosp, London WC1E 6BT, England and Sir Charles Gairdner Hosp, Perth, WA, Australia and Inst Klin Radiol, Mannheim, Germany and New York Med Coll, Our Lady Mercy New York Ctr, New York, NY USA and Ctr Riferimento Oncol, I-33081 Aviano, Italy",
    author = "Vaidya, JS and Wilson, A and Houghton, J and Tobias, JS and Joseph, D and Wenz, F and Hilaris, B and Massarut, S and Keshtgar, M and Sainsbury, R and Taylor, I and D'Souza, D and Saunders, C and Corica, T and Ezio, C and Mauro, A and Baum, M",
    booktitle = "BREAST CANCER RESEARCH AND TREATMENT",
    month = "Jan",
    organization = "SAN ANTONIO, TX",
    pages = "S180--S180",
    publisher = "KLUWER ACADEMIC PUBL",
    title = "Cosmetic outcome after targeted intraoperative radiotherapy (targit) for early breast caner.",
    volume = "82",
    year = "2003",
    startyear = "2003",
    startmonth = "Dec",
    startday = "3",
    finishyear = "2003",
    finishmonth = "Dec",
    finishday = "6",
    issn = "0167-6806",
    language = "EN",
    conference = "26th Annual San Antonio Breast Cancer Symposium",
    }

  • (2003) Mammographic screening for breast cancer (Letter). IN New England Journal of Medicine, 349.611.
    [BibTeX]
    @article{2003mammographicletter,
    author = "",
    editor = "Vaidya, JS and Baum, M",
    journal = "New England Journal of Medicine",
    pages = "611",
    title = "Mammographic screening for breast cancer (Letter)",
    volume = "349",
    year = "2003",
    issn = "0028-4793",
    issue = "6",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "letter",
    keyword = "Mammographic",
    keyword = "screening",
    }

  • Vaidya, J. (2003) Intraoperative radiotherapy for breast cancer. IN Taylor, I. & Johnson, C. (Eds.), Recent Advances in Surgery 26..
    [BibTeX]
    @incollection{vaidya2003intraoperativecancer,
    author = "Vaidya, JS",
    booktitle = "Recent Advances in Surgery 26",
    editor = "Taylor, I and Johnson, CD",
    pages = "167--183",
    publisher = "Churchill Livingston",
    school = "London",
    title = "Intraoperative radiotherapy for breast cancer",
    year = "2003",
    keyword = "advances",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Radiotherapy",
    keyword = "Recent Advances",
    keyword = "surgery",
    }

  • Vaidya, J., Houghton, J., Tobias, J., Keshtgar, M., Sainsbury, R., Taylor, I. & Baum, M. (2003) Updated results of early trials of targeted intraoperative radiotherapy (TARGIT) for breast cancer , 795.
    [BibTeX]
    @inproceedings{vaidya2003updatedcancer,
    author = "Vaidya, JS and Houghton, J and Tobias, J and Keshtgar, M and Sainsbury, R and Taylor, I and Baum, M",
    booktitle = "European Journal of Surgical Oncology",
    note = "British Association of Surgical Oncology, London, 24-25 November 2003",
    pages = "795",
    title = "Updated results of early trials of targeted intraoperative radiotherapy (TARGIT) for breast cancer",
    volume = "29",
    year = "2003",
    issue = "9",
    keyword = "Association",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "British",
    keyword = "cancer",
    keyword = "Intraoperative Radiotherapy",
    keyword = "November",
    keyword = "ONCOLOGY",
    keyword = "Radiotherapy",
    keyword = "Result",
    keyword = "Surgical",
    keyword = "Surgical Oncology",
    keyword = "TRIAL",
    keyword = "TRIALS",
    }

  • Vaidya, J. (2003) The randomised study to test whether addition of ondansetron to droperidol reduces postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy was underpowered. IN J Clin. Anaesthesia, 15.570.
    [BibTeX]
    @article{vaidya2003theunderpowered,
    author = "Vaidya, JS",
    journal = "J Clin. Anaesthesia",
    pages = "570",
    title = "The randomised study to test whether addition of ondansetron to droperidol reduces postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy was underpowered",
    volume = "15",
    year = "2003",
    }

  • (2003) Passive smoking – Study was flawed from outset (Letter). IN BMJ (Clinical Research Ed.), 327.501.
    [BibTeX]
    @article{2003passiveletter,
    author = "",
    editor = "Vaidya, JS",
    journal = "BMJ (Clinical Research Ed.)",
    pages = "501",
    title = "Passive smoking - Study was flawed from outset (Letter)",
    volume = "327",
    year = "2003",
    issn = "0959-8138",
    issue = "7413",
    keyword = "letter",
    keyword = "passive",
    keyword = "Passive Smoking",
    keyword = "Smoking",
    }

  • Gray, L., Vaidya, J., Houghton, J. & Baum, M. (2003) Functional maps: A novel way of visualizing patterns of recurrence of breast cancer , S90.
    [BibTeX]
    @inproceedings{gray2003functionalcancer,
    author = "Gray, L and Vaidya, JS and Houghton, J and Baum, M",
    booktitle = "Breast Cancer Research and Treatment",
    pages = "S90",
    title = "Functional maps: A novel way of visualizing patterns of recurrence of breast cancer",
    volume = "82 (Su",
    year = "2003",
    issue = "372",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "functional",
    keyword = "novel",
    keyword = "Pattern",
    keyword = "PATTERNS",
    keyword = "Recurrence",
    }

  • Vaidiya, J., Tobias, J., Houghton, J., Joseph, D., Wenz, F., Hilaris, B., Massarut, S., Keshtgar, M., Sainsbury, R., Taylor, I., Corica, T., Saunders, C., Roncadin, M., DSouza, D. & Baum, M. (2003) Intra-operative breast radiation: the targeted intra-operative radiotherapy (Targit) trial , S2–S3.
    [BibTeX]
    @inproceedings{vaidiya2003intra-operativetrial,
    author = "Vaidiya, JS and Tobias, JS and Houghton, J and Joseph, D and Wenz, F and Hilaris, BS and Massarut, S and Keshtgar, M and Sainsbury, R and Taylor, I and Corica, T and Saunders, C and Roncadin, M and DSouza, D and Baum, M",
    booktitle = "Breast Cancer Research and Treatment",
    note = "WoS ID: 000186783100007
    JournalEnglishMeeting Abstract1KLUWER ACADEMIC PUBLVAIDYA JS, 2001, ANN ONCOL, V12, P107521747ANDORDRECHTCtr Riferimento Oncol, I-33081 Aviano, ItalyBREAST CANCER RES TREATVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS",
    pages = "S2--S3",
    title = "Intra-operative breast radiation: the targeted intra-operative radiotherapy (Targit) trial",
    volume = "82",
    year = "2003",
    issue = "S1",
    keyword = "TARGIT",
    keyword = "radiotherapy",
    keyword = "intraoperative",
    keyword = "intraoperative radiotherapy",
    keyword = "breast",
    keyword = "breast cancer",
    keyword = "Breast",
    keyword = "Intra-operative",
    keyword = "Intraoperative Radiotherapy",
    keyword = "radiation",
    keyword = "Radiotherapy",
    keyword = "TRIAL",
    keyword = "CANCER",
    keyword = "RADIATION",
    keyword = "TARGIT",
    }

  • Vaidya, J. (2003) Chocolate cigarettes “recruit” children to smoking .
    [BibTeX]
    @techreport{vaidya2003chocolatesmoking,
    author = "Vaidya, JS",
    institution = "",
    journal = "BMJ News Roundup",
    pages = "302",
    title = "Chocolate cigarettes “recruit” children to smoking",
    volume = "326",
    year = "2003",
    }

  • Vaidya, J., Wilson, A., Houghton, J., Tobias, J., Joseph, D., Wenz, F., Hilaris, B., Massarut, S., Keshtgar, M., Sainsbury, R., Taylor, I., D’Souza, D., Saunders, C., Corica, T., Ezio, C., Mauro, A. & Baum, M. (2003) Cosmetic outcome after targeted intraoperative radiotherapy (TARGIT) for early breast cancer. IN Breast Cancer Research and Treatment, 82.1039.
    [BibTeX]
    @article{vaidya2003cosmeticcancer,
    author = "Vaidya, JS and Wilson, A and Houghton, J and Tobias, JS and Joseph, D and Wenz, F and Hilaris, B and Massarut, S and Keshtgar, M and Sainsbury, R and Taylor, I and D'Souza, D and Saunders, C and Corica, T and Ezio, C and Mauro, A and Baum, M",
    journal = "Breast Cancer Research and Treatment",
    note = "WoS ID: 000186783100570
    JournalEnglishMeeting Abstract1KLUWER ACADEMIC PUBLVAIDYA JS, 2001, ANN ONCOL, V12, P107521747ANDORDRECHTUniv Coll London, Middlesex Hosp, London WC1E 6BT, EnglandBREAST CANCER RES TREATVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS",
    pages = "1039",
    title = "Cosmetic outcome after targeted intraoperative radiotherapy (TARGIT) for early breast cancer",
    volume = "82",
    year = "2003",
    issn = "0167-6806",
    issue = "S1",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "Intraoperative Radiotherapy",
    keyword = "outcome",
    keyword = "Radiotherapy",
    keyword = "breast cancer",
    keyword = "CANCER",
    keyword = "radiotherapy",
    keyword = "TARGIT",
    }

  • (2003) Gallstone ileus (Editorial). IN The Lancet, 362.1105.
    [BibTeX]
    @article{2003gallstoneeditorial,
    author = "",
    editor = "Vaidya, JS and Lalude, O and Grant, D and Mukhtar, H",
    journal = "The Lancet",
    pages = "1105",
    title = "Gallstone ileus (Editorial)",
    volume = "362",
    year = "2003",
    issn = "0140-6736",
    issue = "9390",
    keyword = "editorial",
    keyword = "Gallstone",
    }

  • Vaidya, J., Joseph, D., Hilaris, B., Tobias, J., Houghton, J., D’Souza, D., Sainsbury, R., Keshtgar, M., Sainsbury, R., Taylor, I. & Baum, M. (2002) Targeted intraoperative radiotherapy (TARGIT) for breast cancer: an international trial. UCL, London, England and Middlesex Hosp, London, England and Sir Charles Gairdner Hosp, Perth, WA, Australia and Our Lady Mercy New York Med Ctr, New York, NY USA, KLUWER ACADEMIC PUBL, S116–S116.
    [BibTeX]
    @inproceedings{vaidya2002targetedtrial.,
    address = "UCL, London, England and Middlesex Hosp, London, England and Sir Charles Gairdner Hosp, Perth, WA, Australia and Our Lady Mercy New York Med Ctr, New York, NY USA",
    author = "Vaidya, JS and Joseph, D and Hilaris, B and Tobias, JS and Houghton, J and D'Souza, D and Sainsbury, R and Keshtgar, M and Sainsbury, R and Taylor, I and Baum, M",
    booktitle = "BREAST CANCER RESEARCH AND TREATMENT",
    month = "Dec",
    organization = "SAN ANTONIO, TX",
    pages = "S116--S116",
    publisher = "KLUWER ACADEMIC PUBL",
    title = "Targeted intraoperative radiotherapy (TARGIT) for breast cancer: an international trial.",
    volume = "76",
    year = "2002",
    startyear = "2002",
    startmonth = "Dec",
    startday = "11",
    finishyear = "2002",
    finishmonth = "Dec",
    finishday = "14",
    issn = "0167-6806",
    language = "EN",
    conference = "25th San Antonio Breast Cancer Symposium",
    }

  • Vaidya, J. & Palazzo, F. (2002) Radiotherapy in soft-tissue sarcoma.. IN Lancet, 360.1989. doi:10.1016/S0140-6736(02)11902-7
    [BibTeX] [Download PDF]
    @article{vaidya2002radiotherapysarcoma.,
    author = "Vaidya, JS and Palazzo, FF",
    journal = "Lancet",
    month = "Dec",
    organization = "England",
    pages = "1989",
    title = "Radiotherapy in soft-tissue sarcoma.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/12493322",
    volume = "360",
    year = "2002",
    doi = "10.1016/S0140-6736(02)11902-7",
    issn = "0140-6736",
    issue = "9349",
    keyword = "Humans",
    keyword = "Postoperative Period",
    keyword = "Radiation Injuries",
    keyword = "Sarcoma",
    keyword = "Wound Healing",
    language = "eng",
    pii = "S0140-6736(02)11902-7",
    day = "14",
    }

  • Schultheis, C., Sachs, B., Haider, S., Vaidya, J., Palazzo, F., O’Sullivan, B., Bell, R., Davis, A., Turcotte, R. & Zee, B. (2002) Radiotherapy in soft-tissue sarcoma [21] (multiple letters). IN Lancet, 360.1988-1989.
    [BibTeX]
    @article{schultheis2002radiotherapyletters,
    author = "Schultheis, C and Sachs, B and Haider, S and Vaidya, JS and Palazzo, FF and O'Sullivan, B and Bell, R and Davis, A and Turcotte, R and Zee, B",
    journal = "Lancet",
    month = "Dec",
    pages = "1988--1989",
    title = "Radiotherapy in soft-tissue sarcoma [21] (multiple letters)",
    volume = "360",
    year = "2002",
    issn = "0140-6736",
    issue = "9349",
    day = "14",
    }

  • Vaidya, J. (2002) Instructional video demonstrating the novel technique of TARGeted Intraoperative radioTherapy (TARGIT) for breast cancer European Journal of Surgical Oncology.
    [BibTeX] [Download PDF]
    @misc{vaidya2002instructionalcancer,
    author = "Vaidya, JS",
    month = "Jun",
    publisher = "European Journal of Surgical Oncology",
    title = "Instructional video demonstrating the novel technique of TARGeted Intraoperative radioTherapy (TARGIT) for breast cancer",
    url = "http://youtu.be/GVlHGpvRf8A",
    url = "http://youtu.be/GVlHGpvRf8A",
    year = "2002",
    confidential = "False",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "Intraoperative Radiotherapy",
    keyword = "novel",
    keyword = "Radiotherapy",
    keyword = "technique",
    keyword = "Video",
    keyword = "TARGIT",
    keyword = "targeted intraoperative radiotherapy",
    }

  • Vaidya, J., Mukhtar, H. & Bryan, R. (2002) Colonic metastasis from a breast cancer–a case report and a few questions.. IN European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 28.463-464.
    [BibTeX]
    @article{vaidya2002colonicquestions.,
    author = "Vaidya, JS and Mukhtar, H and Bryan, R",
    journal = "European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology",
    month = "Jun",
    pages = "463--464",
    title = "Colonic metastasis from a breast cancer--a case report and a few questions.",
    volume = "28",
    year = "2002",
    issn = "0748-7983",
    issue = "4",
    }

  • Vaidya, J. (2002) 7 Healthcast: Targeting Tumors, 7 News, Boston, USA .
    [BibTeX]
    @misc{vaidya20027usa,
    author = "Vaidya, JS",
    month = "Jun",
    title = "7 Healthcast: Targeting Tumors, 7 News, Boston, USA",
    year = "2002",
    keyword = "news",
    keyword = "Tumor",
    keyword = "TUMORS",
    keyword = "USA",
    day = "6",
    }

  • Vaidya, J., Hall-Craggs, M., Baum, M., Tobias, J., Keshtgar, M., Sainsbury, R. & Taylor, I. (2002) Percutaneous minimally invasive stereotactic primary radiotherapy: A novel approach to breast cancer in elderly women , 37-38.
    [BibTeX]
    @inproceedings{vaidya2002percutaneouswomen,
    author = "Vaidya, JS and Hall-Craggs, M and Baum, M and Tobias, JS and Keshtgar, M and Sainsbury, R and Taylor, I",
    booktitle = "European Journal of Cancer",
    month = "Apr",
    pages = "37--38",
    title = "Percutaneous minimally invasive stereotactic primary radiotherapy: A novel approach to breast cancer in elderly women",
    volume = "37",
    year = "2002",
    issue = "5",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "elderly",
    keyword = "ELDERLY WOMEN",
    keyword = "novel",
    keyword = "percutaneous",
    keyword = "Radiotherapy",
    keyword = "WOMEN",
    }

  • Vaidya, J. & Palazzo, F. (2002) Preoperative radiotherapy for soft tissue sarcoma- correct interpretation of the randomised trial. Preoperative radiotherapy may indeed have a survival benefit but the trial does have enough power to detect it (Letter). IN The Lancet, 360.1988-1989.
    [BibTeX]
    @article{vaidya2002preoperativeletter,
    author = "Vaidya, JS and Palazzo, FF",
    journal = "The Lancet",
    pages = "1988--1989",
    title = "Preoperative radiotherapy for soft tissue sarcoma- correct interpretation of the randomised trial. Preoperative radiotherapy may indeed have a survival benefit but the trial does have enough power to detect it (Letter)",
    volume = "360",
    year = "2002",
    issn = "0140-6736",
    }

  • (2002) Radiotherapy in soft-tissue sarcoma (correct interpretation of the randomised trial) (Letter). IN The Lancet, 360.1988-1989.
    [BibTeX]
    @article{2002radiotherapyletter,
    author = "",
    editor = "Vaidya, JS and Palazzo, FF",
    journal = "The Lancet",
    pages = "1988--1989",
    title = "Radiotherapy in soft-tissue sarcoma (correct interpretation of the randomised trial) (Letter)",
    volume = "360",
    year = "2002",
    issn = "0140-6736",
    issue = "9349",
    keyword = "interpretation",
    keyword = "letter",
    keyword = "Radiotherapy",
    keyword = "SARCOMA",
    keyword = "Soft tissue",
    keyword = "Soft-tissue",
    keyword = "Soft-tissue Sarcoma",
    keyword = "TRIAL",
    }

  • Vaidya, J., Baum, M., Tobias, J., Hougton, J., Keshtgar, M., Sainsbury, R., Taylor, I., D’Souza, D., Metaxas, M., Morgan, S., Harte, K., Sliski, A. & Thomson, E. (2002) Targeted intra operative radiotherapy (Targit) for early breast cancer: Rationale and early clinical experience. IN European Journal of Cancer, 38.S89–S90.
    [BibTeX]
    @article{vaidya2002targetedexperience,
    author = "Vaidya, JS and Baum, M and Tobias, JS and Hougton, J and Keshtgar, M and Sainsbury, R and Taylor, I and D'Souza, DP and Metaxas, M and Morgan, S and Harte, KJ and Sliski, AP and Thomson, E",
    journal = "European Journal of Cancer",
    note = "Journal English Meeting Abstract PERGAMON-ELSEVIER SCIENCE LTD MAR 3 542PE OXFORD Univ Coll London, Dept Surg, London, England EUR J CANCER THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND",
    pages = "S89--S90",
    title = "Targeted intra operative radiotherapy (Targit) for early breast cancer: Rationale and early clinical experience",
    volume = "38",
    year = "2002",
    issn = "0959-8049",
    keyword = "Operative",
    keyword = "Radiotherapy",
    keyword = "Early",
    keyword = "Early Breast Cancer",
    keyword = "Breast",
    keyword = "Breast cancer",
    keyword = "Breast-Cancer",
    keyword = "cancer",
    keyword = "Rationale",
    keyword = "Clinical",
    keyword = "Experience",
    keyword = "abstract",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "clinical",
    keyword = "clinical experience",
    keyword = "CLINICAL-EXPERIENCE",
    keyword = "early breast cancer",
    keyword = "English",
    keyword = "EXPERIENCE",
    keyword = "Intra-operative",
    keyword = "Meeting Abstract",
    keyword = "OXFORD",
    keyword = "RATIONALE",
    keyword = "Science",
    keyword = "SURG",
    keyword = "TARGIT",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "clinical",
    keyword = "clinical experience",
    keyword = "CLINICAL-EXPERIENCE",
    keyword = "early breast cancer",
    keyword = "EXPERIENCE",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Radiotherapy",
    keyword = "RATIONALE",
    keyword = "TARGIT",
    keyword = "intraoperative radiotherapy",
    keyword = "breast cancer",
    }

  • Vaidya, J., Baum, M., Tobias, J., Morgan, S. & D’Souza, D. (2002) The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer. IN European Journal of Surgical Oncology, 28.447-454.
    [BibTeX] [Abstract] [Download PDF]

    Aim: We believe that conservative treatment of early breast cancer may not require radiotherapy that encompasses the whole breast in all patients. We have developed a novel therapeutic approach that allows targeted intraoperative radiotherapy (Targit) to be safely and accurately delivered in a standard operating theatre. We are currently recruiting for a randomized trial testing whether Targit can replace the whole 6 weeks of post-operative radiotherapy after breast conserving surgery. Methods: This paper describes the operative technique. It employs a miniature electron-beam-driven X-ray source called INTRABEAM(TM) (PeC) that emits soft X-rays (50 IN) from within the breast. The X-rays are emitted from the tip of a 10 cm x 3.2 mm diameter probe, that is enclosed in a spherical applicator (available in 2.5-5 cm diameter sizes), which in turn is inserted in the tumour bed and intraoperative radiotherapy is delivered in about 25 min. The prescribed dose is 5 and 20 Gy at 1 cm and 0.2 cm respectively, from the tumour bed. Results: The biologically effective dose is 7-53 Gy for alpha/beta = 10 and 20-120 Gy for alpha/beta = 1.5. The quick attenuation of the radiation reduces the damage to normal tissues and allows radiotherapy to be delivered in a standard operating theatre. Tungsten impregnated rubber sheets, cut to size, are placed on the chest wall to protect the heart/lungs and over the wound to stop stray radiation. The skin dose is monitored with thermoluminescent detectors (TLDs). After wide local excision of the tumour and good haemostasis, a spherical applicator is inserted in the tumour bed and the target breast tissues are wrapped around it with a purse-string suture. Thus, true conformation of the target around the applicator source is achieved in real time. Conclusion: As a tumour bed boost, this technique has the potential to reduce local recurrence by avoiding geographical misses and achieving excellent dosimetry. In patients with low risk of local recurrence, it has the potential to replace the full 6 weeks of post-operative radiotherapy with considerable implications to patients and hospitals. (C) 2002 Elsevier Science Ltd. All rights reserved

    @article{vaidya2002thecancer,
    author = "Vaidya, JS and Baum, M and Tobias, JS and Morgan, S and D'Souza, D",
    journal = "European Journal of Surgical Oncology",
    note = "Journal English Article W B SAUNDERS CO LTD JUN 578CW LONDON Vaidya JS Univ Coll London, Royal Free \\& Univ Coll London Med Sch, Dept Surg, 67-73 Riding House St, London W1W 7EJ, England EUR J SURG ONCOL 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND",
    pages = "447--454",
    title = "The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/12099658",
    volume = "28",
    year = "2002",
    abstract = "Aim: We believe that conservative treatment of early breast cancer may not require radiotherapy that encompasses the whole breast in all patients. We have developed a novel therapeutic approach that allows targeted intraoperative radiotherapy (Targit) to be safely and accurately delivered in a standard operating theatre. We are currently recruiting for a randomized trial testing whether Targit can replace the whole 6 weeks of post-operative radiotherapy after breast conserving surgery. Methods: This paper describes the operative technique. It employs a miniature electron-beam-driven X-ray source called INTRABEAM(TM) (PeC) that emits soft X-rays (50 IN) from within the breast. The X-rays are emitted from the tip of a 10 cm x 3.2 mm diameter probe, that is enclosed in a spherical applicator (available in 2.5-5 cm diameter sizes), which in turn is inserted in the tumour bed and intraoperative radiotherapy is delivered in about 25 min. The prescribed dose is 5 and 20 Gy at 1 cm and 0.2 cm respectively, from the tumour bed. Results: The biologically effective dose is 7-53 Gy for alpha/beta = 10 and 20-120 Gy for alpha/beta = 1.5. The quick attenuation of the radiation reduces the damage to normal tissues and allows radiotherapy to be delivered in a standard operating theatre. Tungsten impregnated rubber sheets, cut to size, are placed on the chest wall to protect the heart/lungs and over the wound to stop stray radiation. The skin dose is monitored with thermoluminescent detectors (TLDs). After wide local excision of the tumour and good haemostasis, a spherical applicator is inserted in the tumour bed and the target breast tissues are wrapped around it with a purse-string suture. Thus, true conformation of the target around the applicator source is achieved in real time. Conclusion: As a tumour bed boost, this technique has the potential to reduce local recurrence by avoiding geographical misses and achieving excellent dosimetry. In patients with low risk of local recurrence, it has the potential to replace the full 6 weeks of post-operative radiotherapy with considerable implications to patients and hospitals. (C) 2002 Elsevier Science Ltd. All rights reserved",
    issn = "0748-7983",
    issue = "4",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "early breast cancer",
    keyword = "Intraoperative Radiotherapy",
    keyword = "novel",
    keyword = "Radiotherapy",
    keyword = "technique",
    keyword = "Breast Cancer",
    keyword = "Intraoperative radiotherapy",
    keyword = "Surgical technique",
    keyword = "As",
    keyword = "attenuation",
    keyword = "BED",
    keyword = "Breast",
    keyword = "breast conserving surgery",
    keyword = "Breast tissue",
    keyword = "CM",
    keyword = "CO",
    keyword = "conformation",
    keyword = "conservative",
    keyword = "conserving",
    keyword = "Damage",
    keyword = "Detectors",
    keyword = "DEVELOPED",
    keyword = "Diameter",
    keyword = "dose",
    keyword = "Dosimetry",
    keyword = "English",
    keyword = "EXCISION",
    keyword = "haemostasis",
    keyword = "Hospital",
    keyword = "HOSPITALS",
    keyword = "IORT",
    keyword = "local",
    keyword = "Local Recurrence",
    keyword = "Low",
    keyword = "May",
    keyword = "MED",
    keyword = "Methods",
    keyword = "MM",
    keyword = "NORMAL-TISSUES",
    keyword = "PAPER",
    keyword = "Patient",
    keyword = "patients",
    keyword = "PROBE",
    keyword = "radiation",
    keyword = "randomized",
    keyword = "RANDOMIZED TRIAL",
    keyword = "RD",
    keyword = "Recurrence",
    keyword = "Result",
    keyword = "rights",
    keyword = "Risk",
    keyword = "Royal",
    keyword = "Science",
    keyword = "size",
    keyword = "SIZES",
    keyword = "Skin",
    keyword = "soft",
    keyword = "ST",
    keyword = "Standard",
    keyword = "SURG",
    keyword = "surgery",
    keyword = "target",
    keyword = "TARGIT",
    keyword = "testing",
    keyword = "therapeutic",
    keyword = "TIME",
    keyword = "Tissue",
    keyword = "Tissues",
    keyword = "treatment",
    keyword = "TRIAL",
    keyword = "Tumour",
    keyword = "TUNGSTEN",
    keyword = "WALL",
    keyword = "X-ray",
    keyword = "X-Rays",
    }

  • Vaidya, J., Joseph, D., Hilaris, B., Tobias, J., Houghton, J., Keshtgar, M., Sainsbury, R. & Taylor, I. (2002) Targeted intraoperative radiotherapy for breast cancer: An international trial , 135.
    [BibTeX]
    @inproceedings{vaidya2002targetedtrial,
    author = "Vaidya, JS and Joseph, D and Hilaris, BS and Tobias, JS and Houghton, J and Keshtgar, M and Sainsbury, R and Taylor, I",
    booktitle = "Abstract Book of ESTRO-21",
    pages = "135",
    title = "Targeted intraoperative radiotherapy for breast cancer: An international trial",
    volume = "21",
    year = "2002",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Radiotherapy",
    keyword = "TRIAL",
    }

  • Vaidya, J., Joseph, D., Keshtgar, M., Sainsbury, R., Taylor, I. & Baum, M. (2002) Targeted intraoperative radiotherapy (TARGIT) for breast cancer: An international trial , 452.
    [BibTeX]
    @inproceedings{vaidya2002targetedtrial,
    author = "Vaidya, JS and Joseph, D and Keshtgar, M and Sainsbury, R and Taylor, I and Baum, M",
    booktitle = "Breast Cancer Research and Treatment",
    pages = "452",
    title = "Targeted intraoperative radiotherapy (TARGIT) for breast cancer: An international trial",
    volume = "76",
    year = "2002",
    issue = "S116",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Radiotherapy",
    keyword = "TRIAL",
    }

  • (2002) Understanding and managing breast cancer: Quo vadis?. IN National Medical Journal of India, 15.252-256.
    [BibTeX]
    @article{2002understandingvadis?,
    author = "",
    editor = "Vaidya, JS",
    journal = "National Medical Journal of India",
    pages = "252--256",
    title = "Understanding and managing breast cancer: Quo vadis?",
    volume = "15",
    year = "2002",
    issue = "5",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "understanding",
    }

  • Scott, M., Vaidya, J., Lock, R., Ingham Clark, C. & Mukhtar, H. (2002) Colorectal cancer follow-up: 5 years’ experience of routine CT scanning , 51.
    [BibTeX]
    @inproceedings{scott2002colorectalscanning,
    author = "Scott, MA and Vaidya, JS and Lock, R and Ingham Clark, CL and Mukhtar, H",
    booktitle = "Colorectal Disease",
    pages = "51",
    title = "Colorectal cancer follow-up: 5 years' experience of routine CT scanning",
    volume = "(Suppl",
    year = "2002",
    keyword = "cancer",
    keyword = "Colorectal",
    keyword = "Colorectal Cancer",
    keyword = "COLORECTAL-CANCER",
    keyword = "ct",
    keyword = "CT Scanning",
    keyword = "EXPERIENCE",
    keyword = "FOLLOW UP",
    keyword = "Follow-up",
    }

  • Vaidya, J. (2002) A novel approach for local treatment of early breast cancer (PhD Thesis) .
    [BibTeX]
    @misc{vaidya2002athesis,
    author = "Vaidya, JS",
    pages = "242",
    title = "A novel approach for local treatment of early breast cancer (PhD Thesis)",
    year = "2002",
    commissioningbody = "University of London",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "early breast cancer",
    keyword = "local",
    keyword = "novel",
    keyword = "PhD",
    keyword = "treatment",
    }

  • Vaidya, J., Hall-Craggs, M., Baum, M., Tobias, J., Falzon, M., D’Souza, D. & Morgan, S. (2002) Percutaneous minimally invasive stereotactic primary radiotherapy for breast cancer. IN The Lancet Oncology, 3.252-253.
    [BibTeX]
    @article{vaidya2002percutaneouscancer,
    address = "Dr. J.S. Vaidya, Department of Surgery, University College of London, 67-73 Riding House Street, London W1W 3EJ; United Kingdom. E-Mail: j.vaidya@ucl.ac.uk",
    author = "Vaidya, JS and Hall-Craggs, M and Baum, M and Tobias, JS and Falzon, M and D'Souza, DP and Morgan, S",
    journal = "The Lancet Oncology",
    note = "High dose of radiation using the PRS400 was delivered to the centre of breast cancer on a stereotactic prone-table as the primary treatment eradicated the tumour. This approach could form the basis of one-stop out-patient treatment of breast cancer, especially for the screen detected small tumours.",
    pages = "252--253",
    publisher = "(Elesevier) LANCET LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND",
    title = "Percutaneous minimally invasive stereotactic primary radiotherapy for breast cancer",
    volume = "3",
    year = "2002",
    issn = "1470-2045",
    issue = "4",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "percutaneous",
    keyword = "Radiotherapy",
    keyword = "English",
    keyword = "RD",
    keyword = "ST",
    keyword = "SURG",
    }

  • Vaidya, J. (2002) Instructional video of Targeted Intraoperative radiotherapy-8 minutes Int J Surgery.
    [BibTeX]
    @misc{vaidya2002instructionalminutes,
    author = "Vaidya, JS",
    howpublished = "Video",
    publisher = "Int J Surgery",
    title = "Instructional video of Targeted Intraoperative radiotherapy-8 minutes",
    year = "2002",
    confidential = "False",
    }

  • (2002) Colonic metastasis from a breast cancer – A case report and a few questions (Letter). IN European Journal of Surgical Oncology, 28.463-464.
    [BibTeX]
    @article{2002colonicletter,
    author = "",
    editor = "Vaidya, JS and Mukhtar, H and Bryan, R",
    journal = "European Journal of Surgical Oncology",
    pages = "463--464",
    title = "Colonic metastasis from a breast cancer - A case report and a few questions (Letter)",
    volume = "28",
    year = "2002",
    issn = "0748-7983",
    issue = "4",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "case report",
    keyword = "Colonic Metastasis",
    keyword = "letter",
    keyword = "METASTASIS",
    keyword = "report",
    }

  • (2002) Management of early-onset breast cancer and BRCA1 or BRCA2 status (Letter). IN The Lancet, 360.640-641.
    [BibTeX]
    @article{2002managementletter,
    author = "",
    editor = "Vaidya, JS and Baum, M",
    journal = "The Lancet",
    pages = "640--641",
    title = "Management of early-onset breast cancer and BRCA1 or BRCA2 status (Letter)",
    volume = "360",
    year = "2002",
    issn = "0140-6736",
    issue = "9333",
    keyword = "BRCA1",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "letter",
    keyword = "Management",
    }

  • (2002) Minimally invasive therapy for the treatment of breast tumours. IN European Journal of Radiology, 42.52-57. doi:10.1016/S0720-048X(02)00019-0
    [BibTeX] [Abstract]

    Minimally invasive therapy has been explored as a potential means of treating breast tumours with minimal disruption to adjacent soft tissues. The purpose of this is to facilitate improved cosmesis and to offer treatment to women who are unfit for surgery. A number of treatment modalities including thermal therapies (intersitital laser photocoagulation, radiofrequency, focused ultrasound and cryotherapy), percutaneous excision and interstitial radiotherapy are being developed. The experience to date of each of these modalities is described and reviewed. Currently there are too few data to indicate the efficacy of these treatments although the preliminary data are encouraging. The need for large-scale studies examining the role of MIT in relationship to the overall management of breast cancer (including chemotherapy, radiotherapy, and the management of the axilla) and outcome is discussed.

    @article{2002minimallytumours,
    author = "",
    editor = "Hall-Craggs, M and Vaidya, JS",
    journal = "European Journal of Radiology",
    pages = "52--57",
    title = "Minimally invasive therapy for the treatment of breast tumours",
    volume = "42",
    year = "2002",
    abstract = "Minimally invasive therapy has been explored as a potential means of treating breast tumours with minimal disruption to adjacent soft tissues. The purpose of this is to facilitate improved cosmesis and to offer treatment to women who are unfit for surgery. A number of treatment modalities including thermal therapies (intersitital laser photocoagulation, radiofrequency, focused ultrasound and cryotherapy), percutaneous excision and interstitial radiotherapy are being developed. The experience to date of each of these modalities is described and reviewed. Currently there are too few data to indicate the efficacy of these treatments although the preliminary data are encouraging. The need for large-scale studies examining the role of MIT in relationship to the overall management of breast cancer (including chemotherapy, radiotherapy, and the management of the axilla) and outcome is discussed.",
    doi = "10.1016/S0720-048X(02)00019-0",
    issn = "0720-048X",
    issue = "1",
    keyword = "Breast",
    keyword = "Breast Tumours",
    keyword = "THERAPIES",
    keyword = "therapy",
    keyword = "treatment",
    keyword = "Tumour",
    keyword = "tumours",
    }

  • Vaidya, J., Tobias, J. & Thomson, E. (2001) Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. BBC Breakfast News .
    [BibTeX]
    @misc{vaidya2001singlenews,
    author = "Vaidya, JS and Tobias, JS and Thomson, ES",
    month = "Dec",
    title = "Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. BBC Breakfast News",
    year = "2001",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "cancer treatment",
    keyword = "dose",
    keyword = "early breast cancer",
    keyword = "May",
    keyword = "news",
    keyword = "radiation",
    keyword = "Radiation therapy",
    keyword = "RADIATION-THERAPY",
    keyword = "SINGLE",
    keyword = "THERAPIES",
    keyword = "therapy",
    keyword = "treatment",
    day = "5",
    }

  • Miller, A., Lee, J., Zuckerman, D., Senn, S., Thornton, H., Duffy, S., Vaidya, J., Dixon-Woods, M., Baum, M., Kurinczuk, J., Rozenberg, S., Ham, H., Liebens, F., Gøizsche, P., Tabar, L. & Smith, R. (2001) Screening for breast cancer with mammography [1] (multiple letters). IN Lancet, 358.2164-2168.
    [BibTeX]
    @article{miller2001screeningletters,
    author = "Miller, AB and Lee, JH and Zuckerman, D and Senn, S and Thornton, H and Duffy, SW and Vaidya, JS and Dixon-Woods, M and Baum, M and Kurinczuk, JJ and Rozenberg, S and Ham, H and Liebens, F and Gøizsche, PC and Tabar, L and Smith, RA",
    journal = "Lancet",
    month = "Dec",
    pages = "2164--2168",
    title = "Screening for breast cancer with mammography [1] (multiple letters)",
    volume = "358",
    year = "2001",
    issn = "0140-6736",
    issue = "9299",
    day = "22",
    }

  • Vaidya, J., Tobias, J. & Thomson, E. (2001) Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. CNN Headline News .
    [BibTeX]
    @misc{vaidya2001singlenews,
    author = "Vaidya, JS and Tobias, JS and Thomson, ES",
    month = "Nov",
    title = "Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. CNN Headline News",
    year = "2001",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "cancer treatment",
    keyword = "dose",
    keyword = "early breast cancer",
    keyword = "May",
    keyword = "news",
    keyword = "radiation",
    keyword = "Radiation therapy",
    keyword = "RADIATION-THERAPY",
    keyword = "SINGLE",
    keyword = "THERAPIES",
    keyword = "therapy",
    keyword = "treatment",
    day = "26",
    }

  • Vaidya, J., Tobias, J. & Thomson, E. (2001) Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. CBS Radio Network .
    [BibTeX]
    @misc{vaidya2001singlenetwork,
    author = "Vaidya, JS and Tobias, JS and Thomson, ES",
    month = "Nov",
    title = "Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. CBS Radio Network",
    year = "2001",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "cancer treatment",
    keyword = "CB",
    keyword = "dose",
    keyword = "early breast cancer",
    keyword = "May",
    keyword = "network",
    keyword = "radiation",
    keyword = "Radiation therapy",
    keyword = "RADIATION-THERAPY",
    keyword = "SINGLE",
    keyword = "THERAPIES",
    keyword = "therapy",
    keyword = "treatment",
    day = "26",
    }

  • Vaidya, J., Tobias, J. & Thomson, E. (2001) Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. IN Los Angeles Times, ..
    [BibTeX]
    @article{vaidya2001singletreatment,
    author = "Vaidya, JS and Tobias, JS and Thomson, ES",
    journal = "Los Angeles Times",
    month = "Nov",
    title = "Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment",
    year = "2001",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "cancer treatment",
    keyword = "dose",
    keyword = "early breast cancer",
    keyword = "May",
    keyword = "radiation",
    keyword = "Radiation therapy",
    keyword = "RADIATION-THERAPY",
    keyword = "SINGLE",
    keyword = "THERAPIES",
    keyword = "therapy",
    keyword = "treatment",
    day = "27",
    }

  • Vaidya, J., Tobias, J. & Thomson, E. (2001) Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. ABC World News Tonight .
    [BibTeX]
    @misc{vaidya2001singletonight,
    author = "Vaidya, JS and Tobias, JS and Thomson, ES",
    month = "Nov",
    title = "Single dose of radiation may be enough to replace radiation therapy in early breast cancer treatment. ABC World News Tonight",
    year = "2001",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "cancer treatment",
    keyword = "dose",
    keyword = "early breast cancer",
    keyword = "May",
    keyword = "news",
    keyword = "radiation",
    keyword = "Radiation therapy",
    keyword = "RADIATION-THERAPY",
    keyword = "SINGLE",
    keyword = "THERAPIES",
    keyword = "therapy",
    keyword = "treatment",
    keyword = "WORLD",
    day = "26",
    }

  • Vaidya, N. & Vaidya, J. (2001) Tobacco: Quit India National Organisation for Tobacco Eradication.
    [BibTeX]
    @book{vaidya2001tobacco:india,
    author = "Vaidya, NS and Vaidya, JS",
    publisher = "National Organisation for Tobacco Eradication",
    school = "Goa",
    title = "Tobacco: Quit India",
    year = "2001",
    keyword = "India",
    keyword = "Tobacco",
    }

  • Vaidya, J., Baum, M., Tobias, J., D’Souza, D., Harte, K. & Naidu, S. (2001) Targeted intraoperative radiotherapy (Targit): A novel approach to local treatment of breast cancer , 31.
    [BibTeX]
    @inproceedings{vaidya2001targetedcancer,
    author = "Vaidya, JS and Baum, M and Tobias, JS and D'Souza, D and Harte, K and Naidu, S",
    booktitle = "Radiotherapy And Oncology",
    pages = "31",
    title = "Targeted intraoperative radiotherapy (Targit): A novel approach to local treatment of breast cancer",
    volume = "58 (Su",
    year = "2001",
    issue = "S10",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "intraoperative",
    keyword = "Intraoperative Radiotherapy",
    keyword = "local",
    keyword = "novel",
    keyword = "Radiotherapy",
    keyword = "TARGIT",
    keyword = "treatment",
    }

  • Vaidya, J., Baum, M., Tobias, J., Houghton, J., Keshtgar, M., Sainsbury, R., Taylor, I., Morgan, S., Metaxas, M. & D’Souza, D. (2001) Targeted intraoperative radiotherapy for breast cancer – a randomised trial. IN Breast Cancer Research and Treatment, 69.145.
    [BibTeX]
    @article{vaidya2001targetedtrial,
    author = "Vaidya, JS and Baum, M and Tobias, JS and Houghton, J and Keshtgar, M and Sainsbury, R and Taylor, I and Morgan, S and Metaxas, M and D'Souza, D",
    journal = "Breast Cancer Research and Treatment",
    note = "Journal English Meeting Abstract KLUWER ACADEMIC PUBL 495MK DORDRECHT Univ Coll London, London, England BREAST CANCER RES TREAT SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS",
    pages = "145",
    title = "Targeted intraoperative radiotherapy for breast cancer - a randomised trial",
    volume = "69",
    year = "2001",
    issn = "0167-6806",
    issue = "3",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "intraoperative",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Radiotherapy",
    keyword = "randomised trial",
    keyword = "TRIAL",
    keyword = "abstract",
    keyword = "Breast",
    keyword = "English",
    keyword = "Meeting Abstract",
    keyword = "Netherlands",
    }

  • Vaidya, J., Baum, M., Tobias, J., Morgan, S. & Thomson, E. (2001) Targeted intraoperative radiotherapy: An innovative method of treatment for early breast cancer , S84–S85.
    [BibTeX]
    @inproceedings{vaidya2001targetedcancer,
    author = "Vaidya, JS and Baum, M and Tobias, JS and Morgan, S and Thomson, E",
    booktitle = "European Journal of Cancer",
    pages = "S84--S85",
    title = "Targeted intraoperative radiotherapy: An innovative method of treatment for early breast cancer",
    volume = "37 (Su",
    year = "2001",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "early breast cancer",
    keyword = "intraoperative",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Radiotherapy",
    keyword = "treatment",
    }

  • Vaidya, J., Tobias, J., Baum, M., Houghton, J., Keshtgar, M. & Sainsbury, R. (2001) Targeted intra-operative radiotherapy (TARGIT) for breast cancer: A randomised trial. IN Radiology, 221.278-278.
    [BibTeX]
    @article{vaidya2001targetedtrial,
    author = "Vaidya, JS and Tobias, JS and Baum, M and Houghton, J and Keshtgar, M and Sainsbury, R",
    journal = "Radiology",
    note = "Journal English Meeting Abstract RADIOLOGICAL SOC NORTH AMERICA NOV S 491UC OAK BROOK RADIOLOGY 820 JORIE BLVD, OAK BROOK, IL 60523 USA",
    pages = "278--278",
    title = "Targeted intra-operative radiotherapy (TARGIT) for breast cancer: A randomised trial",
    volume = "221",
    year = "2001",
    issn = "0033-8419",
    keyword = "abstract",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "English",
    keyword = "Intra-operative",
    keyword = "intraoperative",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Meeting Abstract",
    keyword = "NORTH",
    keyword = "North America",
    keyword = "Radiology",
    keyword = "Radiotherapy",
    keyword = "randomised trial",
    keyword = "S",
    keyword = "targeted intra-operative radiotherapy",
    keyword = "TARGIT",
    keyword = "TRIAL",
    keyword = "USA",
    }

  • Vaidya, J., Baum, M., Tobias, J., D ‘Souza, D., Naidu, S., Morgan, S., Metexas, M., Harte, K., Sliski, A. & Thomson, E. (2001) Targeted Intra-operative Radiotherapy: An Innovative Method of Treatment for Early Breast Cancer. IN Annals of Oncology, 12.1075-1080.
    [BibTeX] [Abstract]

    Introduction: We believe that conservative treatment of early breast cancer may not require radiotherapy that encompasses the whole breast. We present here the clinico-pathological basis for this view, as well as a novel therapeutic approach that allows intra-operative radiotherapy to be safely and accurately delivered to the target tissues in a standard operating theatre. The rationale: Whole-organ analysis of mastectomy specimens reveals that 80% of occult cancer foci are situated remote from the index quadrant. In contrast, over 90% of local recurrences after breast conservative therapy occur near the original tumour, even when radiotherapy is not given. Therefore, the remote occult cancer foci may be clinically irrelevant and radiotherapy to the index quadrant alone might be sufficient. A novel technique: The Photon Radiosurgery System (PRS) is an ingenious portable electron-beam driven device that can typically deliver intra-operative doses of 5-20 Gy, respectively, to 1 cm and 0.2 cm from the tumour bed over about 22 min. The pliable breast tissue – the target – wraps around the source, providing perfect conformal radiotherapy. Being soft X-rays, the dose attenuates rapidly (alpha similar to1/r(3)), reducing distant damage. Results: In our pilot study of 25 patients (age 30-80 year

    @article{vaidya2001targetedcancer,
    author = "Vaidya, JS and Baum, M and Tobias, JS and D 'Souza, DP and Naidu, SV and Morgan, S and Metexas, M and Harte, KJ and Sliski, AP and Thomson, E",
    journal = "Annals of Oncology",
    note = "Journal English Article 12 KLUWER ACADEMIC PUBL *EARL BREAST CANC, 1995, NEW ENGL J MED, V333, P1444; BAUM M, 1997, LANCET, V349, P208; COSGROVE GR, 1997, NEUROSURGERY, V40, P518; DALE RG, 1985, BRIT J RADIOL, V58, P515; DALE RG, 1997, EUR J CANCER, V33, P1707; DENG GR, 1996, SCIENCE, V274, P2057; DOUGLAS RM, 1996, INT J RADIAT ONCOL, V36, P443; FENTIMAN IS, 1996, EUR J CANCER A, V32, P608; FISHER ER, 1992, SEMIN SURG ONCOL, V8, P161; RIBEIRO GG, 1993, CLIN ONCOL, V5, P278; VAIDYA JS, 1996, BRIT J CANCER, V74, P820; VAIDYA JS, 1998, EUR J CANCER, V34, P1143 AUG 467VT DORDRECHT Vaidya JS Univ Coll London, Acad Dept Surg, 67-73 Riding House St, London W1W 7EJ, England ANN ONCOL SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS",
    pages = "1075--1080",
    title = "Targeted Intra-operative Radiotherapy: An Innovative Method of Treatment for Early Breast Cancer",
    volume = "12",
    year = "2001",
    abstract = "Introduction: We believe that conservative treatment of early breast cancer may not require radiotherapy that encompasses the whole breast. We present here the clinico-pathological basis for this view, as well as a novel therapeutic approach that allows intra-operative radiotherapy to be safely and accurately delivered to the target tissues in a standard operating theatre. The rationale: Whole-organ analysis of mastectomy specimens reveals that 80% of occult cancer foci are situated remote from the index quadrant. In contrast, over 90% of local recurrences after breast conservative therapy occur near the original tumour, even when radiotherapy is not given. Therefore, the remote occult cancer foci may be clinically irrelevant and radiotherapy to the index quadrant alone might be sufficient. A novel technique: The Photon Radiosurgery System (PRS) is an ingenious portable electron-beam driven device that can typically deliver intra-operative doses of 5-20 Gy, respectively, to 1 cm and 0.2 cm from the tumour bed over about 22 min. The pliable breast tissue - the target - wraps around the source, providing perfect conformal radiotherapy. Being soft X-rays, the dose attenuates rapidly (alpha similar to1/r(3)), reducing distant damage. Results: In our pilot study of 25 patients (age 30-80 years, T = 0.42-4.0 cm), we replaced the routine post-operative tumour bed boost with targeted intra-operative radiotherapy. There have been no major complications and no patient has developed local recurrence, although the median follow-up time is short, at 24 months. Conclusion: It is safe and feasible to deliver targeted intra- operative radiotherapy (Targit) for early breast cancer. We have begun a randomised trial - the first of its kind - comparing Targit with conventional six-week course of radiotherapy. If proven equivalent in terms of local recurrence and cosmesis, it could eliminate the need for the usual six- week course of post-operative radiotherapy",
    issn = "0923-7534",
    issue = "8",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "Breast cancer/Breast conserving therap",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "early breast cancer",
    keyword = "Intra-operative",
    keyword = "intraoperative",
    keyword = "Intraoperative Radiotherapy",
    keyword = "IORT/Pilot/Randomised tria",
    keyword = "Radiotherapy",
    keyword = "surgery",
    keyword = "targeted intra-operative radiotherapy",
    keyword = "treatment",
    keyword = "Breast cancer",
    keyword = "intraoperative radiotherapy",
    keyword = "1993",
    keyword = "1995",
    keyword = "1996",
    keyword = "age",
    keyword = "ALPHA",
    keyword = "analysis",
    keyword = "As",
    keyword = "BED",
    keyword = "breast conserving therapy/surgery",
    keyword = "Breast tissue",
    keyword = "CM",
    keyword = "COMPLICATION",
    keyword = "complications",
    keyword = "CONFORMAL RADIOTHERAPY",
    keyword = "conservative",
    keyword = "Cosmesis",
    keyword = "Dale",
    keyword = "Damage",
    keyword = "DEVELOPED",
    keyword = "DEVICE",
    keyword = "dose",
    keyword = "driven",
    keyword = "English",
    keyword = "ER",
    keyword = "FOLLOW UP",
    keyword = "Follow-up",
    keyword = "INDEX",
    keyword = "IORT",
    keyword = "IRRADIATION",
    keyword = "local",
    keyword = "Local Recurrence",
    keyword = "M",
    keyword = "mastectomy",
    keyword = "May",
    keyword = "MED",
    keyword = "MULTICENTRICITY",
    keyword = "NEED",
    keyword = "Netherlands",
    keyword = "Neurosurgery",
    keyword = "novel",
    keyword = "Patient",
    keyword = "patients",
    keyword = "Photon",
    keyword = "pilot",
    keyword = "Pilot Studies",
    keyword = "Pilot Study",
    keyword = "PR",
    keyword = "randomised trial",
    keyword = "RATIONALE",
    keyword = "Recurrence",
    keyword = "Result",
    keyword = "SAFE",
    keyword = "Science",
    keyword = "soft",
    keyword = "SPECIMENS",
    keyword = "ST",
    keyword = "Standard",
    keyword = "SURG",
    keyword = "SYSTEM",
    keyword = "target",
    keyword = "TARGET TISSUES",
    keyword = "TARGIT",
    keyword = "technique",
    keyword = "TERM",
    keyword = "therapeutic",
    keyword = "THERAPIES",
    keyword = "therapy",
    keyword = "TIME",
    keyword = "Tissue",
    keyword = "Tissues",
    keyword = "TRIAL",
    keyword = "Tumour",
    keyword = "X-ray",
    keyword = "X-Rays",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "early breast cancer",
    keyword = "intraoperative",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Radiotherapy",
    keyword = "TARGIT",
    keyword = "treatment",
    }

  • Vaidya, J., Baum, M., Tobias, J., Houghton, J., Keshtgar, M., Sainsbury, R., Taylor, I., Morgan, S., Metaxas, M. & D’Souza, D. (2001) Targeted intraoperative radiotherapy for breast cancer – a randomised trial.. IN BREAST CANCER RES TR, 69.228-228.
    [BibTeX]
    @article{vaidya2001targetedtrial.,
    address = "UCL, London, England and Middlesex Hosp, London, England and Canc Res Campaign, Clin Trial Ctr, London SW1Y 5AR, England",
    author = "Vaidya, JS and Baum, M and Tobias, JS and Houghton, J and Keshtgar, M and Sainsbury, R and Taylor, I and Morgan, S and Metaxas, M and D'Souza, D",
    journal = "BREAST CANCER RES TR",
    pages = "228--228",
    publisher = "KLUWER ACADEMIC PUBL",
    title = "Targeted intraoperative radiotherapy for breast cancer - a randomised trial.",
    volume = "69",
    year = "2001",
    issn = "0167-6806",
    issue = "3",
    language = "EN",
    }

  • (2001) Screening for breast cancer with mammography. IN The Lancet, 358.2164-2168. doi:10.1016/S0140-6736(01)07195-1
    [BibTeX]
    @article{2001screeningmammography,
    author = "",
    editor = "Vaidya, JS",
    journal = "The Lancet",
    note = "Imported via OAI, 7:29:01 2nd Sep 2005",
    pages = "2164--2168",
    title = "Screening for breast cancer with mammography",
    volume = "358",
    year = "2001",
    doi = "10.1016/S0140-6736(01)07195-1",
    issn = "0140-6736",
    issue = "9299",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "Mammography",
    keyword = "screening",
    }

  • (2001) India’s new smoking laws. IN The Lancet Oncology, 2.198.
    [BibTeX]
    @article{2001indiaslaws,
    author = "",
    editor = "Vaidya, JS",
    journal = "The Lancet Oncology",
    pages = "198",
    title = "India's new smoking laws",
    volume = "2",
    year = "2001",
    issn = "1470-2045",
    issue = "4",
    keyword = "India",
    keyword = "law",
    keyword = "Laws",
    keyword = "Smoking",
    }

  • Vaidya, J., Baum, M., Tobias, J., Houghton, J. & Keshtgar, M. (2001) Breast cancer research and treatment. , 145.
    [BibTeX]
    @inproceedings{vaidya2001breasttreatment.,
    author = "Vaidya, JS and Baum, M and Tobias, JS and Houghton, J and Keshtgar, MRSEA",
    booktitle = "British Journal of Surgery",
    pages = "145",
    title = "Breast cancer research and treatment.",
    volume = "69",
    year = "2001",
    issue = "3",
    }

  • Vaidya, J. & Vaidya, S. (2001) People cannot compute (more good- less bad = good press)(e-Letter). IN BMJ, ..
    [BibTeX] [Download PDF]
    @article{vaidya2001peoplepresse-letter,
    author = "Vaidya, JS and Vaidya, SJ",
    journal = "BMJ",
    title = "People cannot compute (more good- less bad = good press)(e-Letter)",
    url = "http://bmj.com/cgi/eletters/323/7316/782#17264",
    year = "2001",
    issn = "0959-8138",
    }

  • Vaidya, J., Tobias, J., Baum, M., Houghton, J., Keshtgar, M. & Sainsbury, R. (2001) Targeted intra-operative radiotherapy (TARGIT) for breast cancer – a randomised trial. , 113-114.
    [BibTeX]
    @inproceedings{vaidya2001targetedtrial.,
    author = "Vaidya, JS and Tobias, JS and Baum, M and Houghton, J and Keshtgar, MRS and Sainsbury, REA",
    booktitle = "Radiology",
    pages = "113--114",
    title = "Targeted intra-operative radiotherapy (TARGIT) for breast cancer - a randomised trial.",
    volume = "27",
    year = "2001",
    }

  • Vaidya, J., Baum, M., Tobias, J., Houghton, J., Keshtgar, M., Sainsbury, R., Taylor, I., D’Souza, D., Morgan, S., Metaxas, M., Harte, K., Sliski, A. & Thomson, E. (2001) Targeted intra-operative radiotherapy (TARGIT) for breast cancer – a randomised trial , 37-37. doi:10.1016/S0959-8049(01)80140-4
    [BibTeX]
    @inproceedings{vaidya2001targetedtrial,
    author = "Vaidya, JS and Baum, M and Tobias, JS and Houghton, J and Keshtgar, M and Sainsbury, R and Taylor, I and D'Souza, D and Morgan, S and Metaxas, M and Harte, K and Sliski, A and Thomson, E",
    booktitle = "European Journal of Cancer",
    pages = "37--37",
    title = "Targeted intra-operative radiotherapy (TARGIT) for breast cancer - a randomised trial",
    volume = "37",
    year = "2001",
    doi = "10.1016/S0959-8049(01)80140-4",
    issue = "Suppl 5",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "BREAST-CANCER",
    keyword = "cancer",
    keyword = "early breast cancer",
    keyword = "intraoperative",
    keyword = "Intraoperative Radiotherapy",
    keyword = "Radiotherapy",
    keyword = "randomised trial",
    keyword = "TARGIT",
    keyword = "TRIAL",
    keyword = "Intraoperative",
    keyword = "Breast cancer",
    keyword = "Breast-Cancer",
    keyword = "Randomised",
    keyword = "Randomised Trial",
    keyword = "Trial",
    }

  • Vaidya, J. (2000) Carlton Television – Intra-operative radiotherapy for breast cancer .
    [BibTeX]
    @misc{vaidya2000carltoncancer,
    author = "Vaidya, JS",
    month = "Nov",
    title = "Carlton Television - Intra-operative radiotherapy for breast cancer",
    year = "2000",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "cancer",
    keyword = "Intra-operative",
    keyword = "Radiotherapy",
    day = "8",
    }

  • Vaidya, J. (2000) Tomorrow’s World – Surgery and intra-operative radiotherapy for breast cancer .
    [BibTeX]
    @misc{vaidya2000tomorrowscancer,
    author = "Vaidya, JS",
    month = "Nov",
    title = "Tomorrow's World - Surgery and intra-operative radiotherapy for breast cancer",
    year = "2000",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "cancer",
    keyword = "Intra-operative",
    keyword = "Radiotherapy",
    keyword = "surgery",
    day = "8",
    }

  • Vaidya, J. (2000) Re: \"Safety valve\" effect of spanking – a flawed justification. IN BMJ, ..
    [BibTeX] [Download PDF]
    @article{vaidya2000re:justification,
    author = "Vaidya, JS",
    journal = "BMJ",
    title = "Re: \"Safety valve\" effect of spanking - a flawed justification",
    url = "http://bmj.com/cgi/eletters/320/7230/261#6474",
    year = "2000",
    issn = "0959-8138",
    }

  • Vaidya, J., Baum, M., Tobias, J., D’Souza, D., Harte, K. & Naidu, S. (2000) Targeted intraoperative radiotherapy (Targit) – A novel approach to local treatment of breast cancer , 862.
    [BibTeX]
    @inproceedings{vaidya2000targetedcancer,
    author = "Vaidya, JS and Baum, M and Tobias, JS and D'Souza, D and Harte, K and Naidu, S",
    booktitle = "European Journal of Surgical Oncology",
    pages = "862",
    title = "Targeted intraoperative radiotherapy (Targit) - A novel approach to local treatment of breast cancer",
    volume = "26",
    year = "2000",
    issue = "8",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "cancer",
    keyword = "Intra-operative",
    keyword = "local",
    keyword = "novel",
    keyword = "Radiotherapy",
    keyword = "treatment",
    }

  • Vaidya, J. (2000) Minor-injury care by nurse practitioners or junior doctors (Letter). IN The Lancet, 355.229.
    [BibTeX]
    @article{vaidya2000minor-injuryletter,
    author = "Vaidya, JS",
    editor = "Vaidya, JS",
    journal = "The Lancet",
    pages = "229",
    title = "Minor-injury care by nurse practitioners or junior doctors (Letter)",
    volume = "355",
    year = "2000",
    issn = "0140-6736",
    issue = "9199",
    keyword = "Care",
    keyword = "letter",
    keyword = "Minor Injury",
    }

  • Vaidya, J., Keshtgar, M. & Baum, M. (2000) Diseases of the breast. IN British Journal of Cancer, 83.1769-1770.
    [BibTeX]
    @article{vaidya2000diseasesbreast,
    author = "Vaidya, JS and Keshtgar, M and Baum, M",
    journal = "British Journal of Cancer",
    pages = "1769--1770",
    title = "Diseases of the breast",
    volume = "83",
    year = "2000",
    issn = "0007-0920",
    issue = "12",
    keyword = "Breast",
    keyword = "disease",
    keyword = "Diseases",
    }

  • Vaidya, J., Baum, M., Tobias, J., D’Souza, D., Harte, K. & Naidu, S. (2000) Targeted intraoperative radiotherapy (Targit) – A novel approach to local treatment of early breast cancer , 339.
    [BibTeX]
    @inproceedings{vaidya2000targetedcancer,
    author = "Vaidya, JS and Baum, M and Tobias, JS and D'Souza, D and Harte, K and Naidu, S",
    booktitle = "Breast",
    pages = "339",
    title = "Targeted intraoperative radiotherapy (Targit) - A novel approach to local treatment of early breast cancer",
    volume = "6",
    year = "2000",
    issue = "5",
    keyword = "Breast",
    keyword = "BREAST CANCER",
    keyword = "cancer",
    keyword = "Intra-operative",
    keyword = "local",
    keyword = "novel",
    keyword = "Radiotherapy",
    keyword = "treatment",
    }

  • VAIDYA, J., Baum, M., Tobias, J. & Houghton, J. (1999) Randomised Controlled Clinical Trial: Targeted Intraoperative radiotherapy (Targit)- comparing targeted intra-operative radiotherapy with conventional post-operative radiotherapy after breast conserving surgery for early stage breast cancer.. IN The Lancet, ..
    [BibTeX] [Download PDF]
    @article{vaidya1999randomisedcancer.,
    author = "VAIDYA, J and Baum, M and Tobias, JS and Houghton, J",
    journal = "The Lancet",
    month = "Dec",
    number = "99PRT-47",
    organization = "UK",
    title = "Randomised Controlled Clinical Trial: Targeted Intraoperative radiotherapy (Targit)- comparing targeted intra-operative radiotherapy with conventional post-operative radiotherapy after breast conserving surgery for early stage breast cancer.",
    url = "http://www.thelancet.com/journals/lancet/misc/protocol/99PRT-47%20PDF",
    year = "1999",
    publicationstatus = "published",
    }

  • Vaidya, J., Baum, M., Quinn, M., Babb, P., Jones, J., Adab, P., McGhee, S. & Hedley, A. (1999) Screening and mortality from cervical cancer (multiple letters) [4]. IN British Medical Journal, 319.642-643.
    [BibTeX]
    @article{vaidya1999screening[4],
    author = "Vaidya, JS and Baum, M and Quinn, MJ and Babb, PJ and Jones, J and Adab, P and McGhee, S and Hedley, A",
    journal = "British Medical Journal",
    month = "Sep",
    pages = "642--643",
    title = "Screening and mortality from cervical cancer (multiple letters) [4]",
    volume = "319",
    year = "1999",
    issn = "0959-8146",
    issue = "7210",
    day = "4",
    }

  • Vaidya, J. & Baum, M. (1999) Screening and mortality from cervical cancer. Does screening really reduce mortality?. IN BMJ, 319.642.
    [BibTeX] [Download PDF]
    @article{vaidya1999screeningmortality?,
    author = "Vaidya, JS and Baum, M",
    journal = "BMJ",
    month = "Sep",
    note = "PMCID: PMC1116502",
    organization = "ENGLAND",
    pages = "642",
    title = "Screening and mortality from cervical cancer. Does screening really reduce mortality?",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/10473491",
    volume = "319",
    year = "1999",
    issn = "0959-8138",
    issue = "7210",
    keyword = "Adult",
    keyword = "Female",
    keyword = "Humans",
    keyword = "Mass Screening",
    keyword = "Middle Aged",
    keyword = "Uterine Cervical Neoplasms",
    language = "eng",
    day = "4",
    }

  • Vaidya, J., Baum, M., Tobias, J., D’Souza, D., Naidu, S., Morgan, S., Harte, K., Sliski, A., Thomson, E. & Varricchione, T. (1999) Radiosurgery: An innovative method of local treatment for breast cancer. IN BRIT J CANCER, 80.100-100.
    [BibTeX]
    @article{vaidya1999radiosurgery:cancer,
    address = "UCL, Dept Surg 1, London, England and UCL, Dept Radiat Oncol, London, England and UCL, Dept Med Phys, London, England",
    author = "Vaidya, JS and Baum, M and Tobias, JS and D'Souza, DP and Naidu, SV and Morgan, S and Harte, KJ and Sliski, AP and Thomson, E and Varricchione, TR",
    journal = "BRIT J CANCER",
    month = "Jul",
    pages = "100--100",
    publisher = "CHURCHILL LIVINGSTONE",
    title = "Radiosurgery: An innovative method of local treatment for breast cancer",
    volume = "80",
    year = "1999",
    issn = "0007-0920",
    language = "EN",
    }

  • Vaidya, S., Vaidya, J. & Naik, U. (1999) Sports sponsorship by cigarette companies influences the adolescent children’s mind and helps initiate smoking: results of a national study in India. IN Journal of the Indian Medical Association, 97.354–356, 359.
    [BibTeX]
    @article{vaidya1999sportsindia,
    author = "Vaidya, SG and Vaidya, JS and Naik, UD",
    journal = "Journal of the Indian Medical Association",
    note = "Imported via OAI, 7:29:01 1st Sep 2005",
    pages = "354--356, 359",
    title = "Sports sponsorship by cigarette companies influences the adolescent children's mind and helps initiate smoking: results of a national study in India",
    volume = "97",
    year = "1999",
    issn = "0019-5847",
    issue = "9",
    }

  • (1999) The price of autonomy. IN Health Expectations, 2.78-81.
    [BibTeX]
    @article{1999theautonomy,
    author = "",
    editor = "Baum, M and Vaidya, JS",
    journal = "Health Expectations",
    pages = "78--81",
    title = "The price of autonomy",
    volume = "2",
    year = "1999",
    issn = "1369-6513",
    keyword = "Autonomy",
    }

  • Vaidya, J. & Baum, M. (1999) Randomised trials are not unethical. IN The Lancet, 353.1714.
    [BibTeX]
    @article{vaidya1999randomisedunethical,
    author = "Vaidya, JS and Baum, M",
    journal = "The Lancet",
    pages = "1714",
    title = "Randomised trials are not unethical",
    volume = "353",
    year = "1999",
    issn = "0140-6736",
    }

  • Vaidya, J. & Baum, M. (1999) The Enigma of Breast Cancer Metastasis. IN Ian, F. (Ed.), Challenges in Breast Cancer..
    [BibTeX]
    @incollection{vaidya1999themetastasis,
    author = "Vaidya, JS and Baum, M",
    booktitle = "Challenges in Breast Cancer",
    editor = "Ian, F",
    number = "1",
    pages = "3--17",
    publisher = "Blackwell Science",
    school = "London",
    title = "The Enigma of Breast Cancer Metastasis",
    year = "1999",
    }

  • Vaidya, J. & Baum, M. (1999) Does screening really reduce mortality?. IN BMJ, 319.642.
    [BibTeX]
    @article{vaidya1999doesmortality?,
    author = "Vaidya, JS and Baum, M",
    journal = "BMJ",
    pages = "642",
    title = "Does screening really reduce mortality?",
    volume = "319",
    year = "1999",
    issn = "0959-8138",
    }

  • Vaidya, J. & Baum, M. (1999) Early Cancer\" vs. \"Dormant Cancer\" and the potential hazards of the rush to surgery(e-Letter) .
    [BibTeX] [Download PDF]
    @misc{vaidya1999earlysurgerye-letter,
    author = "Vaidya, JS and Baum, M",
    journal = "BMJ",
    title = "Early Cancer\" vs. \"Dormant Cancer\" and the potential hazards of the rush to surgery(e-Letter)",
    url = "http://www.bmj.com/cgi/eletters/319/7210/642#EL4",
    year = "1999",
    issn = "0959-8138",
    }

  • (1999) Does breast cancer exist in a state of chaos?. IN European Journal of Cancer, 35.886-891. doi:10.1016/S0959-8049(99)00067-2
    [BibTeX]
    @article{1999doeschaos?,
    author = "",
    editor = "Baum, M and Chaplain, M and Anderson, A and Douek, M and Vaidya, JS",
    journal = "European Journal of Cancer",
    note = "Imported via OAI, 7:29:01 2nd Sep 2005",
    pages = "886--891",
    title = "Does breast cancer exist in a state of chaos?",
    volume = "35",
    year = "1999",
    doi = "10.1016/S0959-8049(99)00067-2",
    issn = "0959-8049",
    issue = "6",
    keyword = "Angiogenesis",
    keyword = "Breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "Mathematical Model",
    keyword = "MRI",
    keyword = "State",
    }

  • VAIDYA, J. (1998) Ethics of hepatitis B virus transmission between healthcare workers and patients Lancet Website.
    [BibTeX] [Download PDF]
    @misc{vaidya1998ethicspatients,
    author = "VAIDYA, J",
    month = "Nov",
    publisher = "Lancet Website",
    title = "Ethics of hepatitis B virus transmission between healthcare workers and patients",
    url = "http://www.thelancet.com/newlancet/sub/discuss/TOP79/msg00000.html",
    year = "1998",
    language = "English",
    day = "30",
    publicationstatus = "published",
    }

  • Douek, M., Vaidya, J., Davidson, T., Lakhani, S., Hall-Craggs, M., Baum, M. & Taylor, I. (1998) Preoperative MRI does not influence the amount of breast tissue excised in conservative cancer surgery. IN EUR J CANCER, 34.S45–S46.
    [BibTeX]
    @article{douek1998preoperativesurgery,
    address = "UCL, Dept Surg, Sch Med, London W1P 7LD, England and UCL, Dept Histopathol, Sch Med, London W1P 7LD, England and UCL, Dept Radiol, Sch Med, London W1P 7LD, England",
    author = "Douek, M and Vaidya, J and Davidson, T and Lakhani, SR and Hall-Craggs, MA and Baum, M and Taylor, I",
    journal = "EUR J CANCER",
    month = "Sep",
    pages = "S45--S46",
    publisher = "PERGAMON-ELSEVIER SCIENCE LTD",
    title = "Preoperative MRI does not influence the amount of breast tissue excised in conservative cancer surgery",
    volume = "34",
    year = "1998",
    issn = "0959-8049",
    language = "EN",
    }

  • VAIDYA, J. (1998) Patients’ expectations of adjuvant chemotherapy Lancet Website.
    [BibTeX] [Download PDF]
    @misc{vaidya1998patientschemotherapy,
    author = "VAIDYA, J",
    month = "Sep",
    publisher = "Lancet Website",
    title = "Patients’ expectations of adjuvant chemotherapy",
    url = "http://www.thelancet.com/newlancet/sub/discuss/TOP61/msg00000.html",
    year = "1998",
    language = "English",
    day = "7",
    publicationstatus = "published",
    }

  • Douek, M., Vaidya, J., Davidson, T., Lakhani, S., Hall-Crag, M., Blanchard, K., Baum, M. & Taylor, I. (1998) Pre-operative detection of breast cancer multicentricity with MRI. IN EUR J CANCER, 34.S71–S71.
    [BibTeX]
    @article{douek1998pre-operativemri,
    address = "UCL, Sch Med, Dept Radiol, London W1P 7LD, England and UCL, Sch Med, Dept Histopathol, London W1P 7LD, England and UCL, Sch Med, Dept Radiol, London W1P 7LD, England",
    author = "Douek, M and Vaidya, J and Davidson, T and Lakhani, SR and Hall-Crag, MA and Blanchard, K and Baum, M and Taylor, I",
    journal = "EUR J CANCER",
    month = "Sep",
    pages = "S71--S71",
    publisher = "PERGAMON-ELSEVIER SCIENCE LTD",
    title = "Pre-operative detection of breast cancer multicentricity with MRI",
    volume = "34",
    year = "1998",
    issn = "0959-8049",
    language = "EN",
    }

  • Douek, M., Vaidya, J., Baum, M., Taylor, I., Drew, P., Turnbull, L. & Kerin, M. (1998) Magnetic-resonance imaging and breast cancer multicentricity (multiple letters) [5]. IN Lancet, 352.652-653.
    [BibTeX]
    @article{douek1998magnetic-resonance[5],
    author = "Douek, M and Vaidya, JS and Baum, M and Taylor, I and Drew, PJ and Turnbull, LW and Kerin, MJ",
    journal = "Lancet",
    month = "Aug",
    pages = "652--653",
    title = "Magnetic-resonance imaging and breast cancer multicentricity (multiple letters) [5]",
    volume = "352",
    year = "1998",
    issn = "0140-6736",
    issue = "9128",
    day = "22",
    }

  • VAIDYA, J. (1998) Geographic latitude and major depression Lancet Website.
    [BibTeX] [Download PDF]
    @misc{vaidya1998geographicdepression,
    author = "VAIDYA, J",
    month = "Aug",
    publisher = "Lancet Website",
    title = "Geographic latitude and major depression",
    url = "http://www.thelancet.com/newlancet/sub/discuss/TOP51/msg00000.html",
    year = "1998",
    language = "English",
    day = "13",
    publicationstatus = "published",
    }

  • Conolly, S., Hearnshaw, S., Low, S., Edwards, R., Tokuda, Y., Vaidya, J., Baum, M. & Sone, S. (1998) Low-dose spiral computed tomography for lung-cancer screening (multiple letters) [4]. IN Lancet, 352.235-237.
    [BibTeX]
    @article{conolly1998low-dose[4],
    author = "Conolly, S and Hearnshaw, S and Low, S and Edwards, R and Tokuda, Y and Vaidya, JS and Baum, M and Sone, S",
    journal = "Lancet",
    month = "Jul",
    pages = "235--237",
    title = "Low-dose spiral computed tomography for lung-cancer screening (multiple letters) [4]",
    volume = "352",
    year = "1998",
    issn = "0140-6736",
    issue = "9123",
    day = "18",
    }

  • Vaidya, J., Fahey, T., Peters, T., Iacoviello, L., Donati, M., Jolobe, O., Meade, T. & Brennan, P. (1998) Interpretation of Thrombosis Prevention Trial (multiple letters) [1]. IN Lancet, 351.1204-1207.
    [BibTeX]
    @article{vaidya1998interpretation[1],
    author = "Vaidya, JS and Fahey, T and Peters, TJ and Iacoviello, L and Donati, MB and Jolobe, OMP and Meade, TW and Brennan, PJ",
    journal = "Lancet",
    month = "Apr",
    pages = "1204--1207",
    title = "Interpretation of Thrombosis Prevention Trial (multiple letters) [1]",
    volume = "351",
    year = "1998",
    issn = "0140-6736",
    issue = "9110",
    day = "18",
    }

  • Badwe, R., Bhansali, M. & Vaidya, J. (1998) Unopposed oestrogen and survival of breast cancer. IN BREAST, 7.66-71.
    [BibTeX] [Abstract]

    It has been suggested that survival of breast cancer patients may be affected by their hormonal milieu. the level of circulating oestrogen in a woman’s body changes with the phase of menstrual cycle, the amount of body fat and her menopausal status. We examined whether these factors affect survival from breast cancer. Meta-analysis of relevant literature for age (reflecting menopausal status; 22 studies), timing of surgery during the menstrual cycle in premenopausal women (28 studies) and body weight in postmenopausal women (18 studies), was carried out to determine the effect of unopposed oestrogen at the time of surgery on survival in breast cancer. The meta-analyses revealed a significantly better survival in premenopausal vs postmenopausal patients (OR 0.76, CI 0.74-0.78, 2P < 0.0000001), in patients who were operated in the luteal vs follicular phase of the menstrual cycle (OR 0.87, CI 0.79-0.97, 2P < 0.02), and in postmenopausal women who were not obese vs obese (OR 0.64, CI 0.59-0.70 2P < 0.0000001). These data indicate that unopposed oestrogen at the time of surgery may have a deleterious effect on survival in women of all ages. It prompts future research into changing the hormonal milieu at the time of surgery as a means of improving survival.

    @article{badwe1998unopposedcancer,
    address = "Tata Mem Hosp, Dept Surg Oncol, Bombay 400012, Maharashtra, India and UCL, Dept Surg, London, England",
    author = "Badwe, RA and Bhansali, MS and Vaidya, JS",
    journal = "BREAST",
    month = "Apr",
    pages = "66--71",
    publisher = "CHURCHILL LIVINGSTONE",
    title = "Unopposed oestrogen and survival of breast cancer",
    volume = "7",
    year = "1998",
    abstract = "It has been suggested that survival of breast cancer patients may be affected by their hormonal milieu. the level of circulating oestrogen in a woman's body changes with the phase of menstrual cycle, the amount of body fat and her menopausal status. We examined whether these factors affect survival from breast cancer. Meta-analysis of relevant literature for age (reflecting menopausal status; 22 studies), timing of surgery during the menstrual cycle in premenopausal women (28 studies) and body weight in postmenopausal women (18 studies), was carried out to determine the effect of unopposed oestrogen at the time of surgery on survival in breast cancer. The meta-analyses revealed a significantly better survival in premenopausal vs postmenopausal patients (OR 0.76, CI 0.74-0.78, 2P < 0.0000001), in patients who were operated in the luteal vs follicular phase of the menstrual cycle (OR 0.87, CI 0.79-0.97, 2P < 0.02), and in postmenopausal women who were not obese vs obese (OR 0.64, CI 0.59-0.70 2P < 0.0000001). These data indicate that unopposed oestrogen at the time of surgery may have a deleterious effect on survival in women of all ages. It prompts future research into changing the hormonal milieu at the time of surgery as a means of improving survival.",
    issn = "0960-9776",
    issue = "2",
    keyword = "DISEASE-FREE SURVIVAL",
    keyword = "BODY-MASS INDEX",
    keyword = "MENSTRUAL-CYCLE",
    keyword = "PREMENOPAUSAL WOMEN",
    keyword = "PROGNOSTIC FACTOR",
    keyword = "SURGICAL CURE",
    keyword = "POSTMENOPAUSAL WOMEN",
    keyword = "INFLUENCES DURATION",
    keyword = "MAMMARY-CARCINOMA",
    keyword = "RISK-FACTORS",
    language = "EN",
    }

  • Vaidya, J. & Mittra, I. (1998) New method of expressing survival in cancer is popular.. IN BMJ, 316.1092.
    [BibTeX] [Download PDF]
    @article{vaidya1998newpopular.,
    author = "Vaidya, JS and Mittra, I",
    journal = "BMJ",
    month = "Apr",
    note = "PMCID: PMC1112913",
    organization = "ENGLAND",
    pages = "1092",
    title = "New method of expressing survival in cancer is popular.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/9552922",
    volume = "316",
    year = "1998",
    issn = "0959-8138",
    issue = "7137",
    keyword = "Humans",
    keyword = "Life Expectancy",
    keyword = "Neoplasms",
    keyword = "Survival Analysis",
    language = "eng",
    day = "4",
    }

  • VAIDYA, J. (1998) Meditating on Yogic Science: attn: lateral posture switches ANS. Lancet Website.
    [BibTeX] [Download PDF]
    @misc{vaidya1998meditatingans.,
    author = "VAIDYA, J",
    month = "Apr",
    publisher = "Lancet Website",
    title = "Meditating on Yogic Science: attn: lateral posture switches ANS.",
    url = "http://www.thelancet.com/newlancet/sub/discuss/TOP20/msg00000.html",
    year = "1998",
    day = "6",
    publicationstatus = "published",
    }

  • VAIDYA, J. (1998) Pleasures (?) of pipe smoking Lancet Website.
    [BibTeX] [Download PDF]
    @misc{vaidya1998pleasuressmoking,
    author = "VAIDYA, J",
    month = "Apr",
    publisher = "Lancet Website",
    title = "Pleasures (?) of pipe smoking",
    url = "http://www.thelancet.com/newlancet/sub/discuss/TOP25/msg00000.html",
    year = "1998",
    language = "English",
    day = "20",
    publicationstatus = "published",
    }

  • Vaidya, J. & Vaidya, S. (1998) The tobacco settlement.. IN N Engl J Med, 338.690-691.
    [BibTeX] [Download PDF]
    @article{vaidya1998thesettlement.,
    author = "Vaidya, JS and Vaidya, SG",
    journal = "N Engl J Med",
    month = "Mar",
    organization = "UNITED STATES",
    pages = "690--691",
    title = "The tobacco settlement.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/9490396",
    volume = "338",
    year = "1998",
    issn = "0028-4793",
    issue = "10",
    keyword = "Developing Countries",
    keyword = "Humans",
    keyword = "Smoking",
    keyword = "Tobacco Industry",
    keyword = "United States",
    language = "eng",
    day = "5",
    }

  • VAIDYA, J. (1998) Salt intake: could the human faculty of taste be used to decide what we eat? Lancet Website.
    [BibTeX] [Download PDF]
    @misc{vaidya1998salteat?,
    author = "VAIDYA, J",
    month = "Mar",
    publisher = "Lancet Website",
    title = "Salt intake: could the human faculty of taste be used to decide what we eat?",
    url = "http://www.thelancet.com/newlancet/sub/discuss/TOP7/msg00000.html",
    year = "1998",
    language = "English",
    day = "13",
    publicationstatus = "published",
    }

  • Douek, M., Vaidya, J., Lakhani, S., Hall-Craggs, M., Baum, M. & Taylor, I. (1998) Can magnetic-resonance imaging help elucidate natural history of breast cancer multicentricity?. IN Lancet, 351.801-802. doi:10.1016/S0140-6736(98)24011-6
    [BibTeX] [Download PDF]
    @article{douek1998canmulticentricity?,
    author = "Douek, M and Vaidya, JS and Lakhani, SR and Hall-Craggs, MA and Baum, M and Taylor, I",
    journal = "Lancet",
    month = "Mar",
    organization = "ENGLAND",
    pages = "801--802",
    title = "Can magnetic-resonance imaging help elucidate natural history of breast cancer multicentricity?",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/9519954",
    volume = "351",
    year = "1998",
    doi = "10.1016/S0140-6736(98)24011-6",
    issn = "0140-6736",
    issue = "9105",
    keyword = "Breast",
    keyword = "Breast Neoplasms",
    keyword = "Contrast Media",
    keyword = "Female",
    keyword = "Gadolinium DTPA",
    keyword = "Humans",
    keyword = "Magnetic Resonance Imaging",
    keyword = "Prospective Studies",
    keyword = "Sensitivity and Specificity",
    language = "eng",
    pii = "S0140-6736(98)24011-6",
    day = "14",
    }

  • Tillotson, R., Vaidya, J., Vaidya, S. & Pohl, R. (1998) The tobacco settlement [6] (multiple letters). IN New England Journal of Medicine, 338.690-691. doi:10.1056/NEJM199803053381015
    [BibTeX]
    @article{tillotson1998theletters,
    author = "Tillotson, R and Vaidya, JS and Vaidya, SG and Pohl, R",
    journal = "New England Journal of Medicine",
    month = "Mar",
    pages = "690--691",
    title = "The tobacco settlement [6] (multiple letters)",
    volume = "338",
    year = "1998",
    doi = "10.1056/NEJM199803053381015",
    issn = "0028-4793",
    issue = "10",
    day = "5",
    }

  • Sadler, P., Luik, J., Charlton, A., While, D., Kelly, S., Vaidya, S. & Vaidya, J. (1998) Tobacco sponsorship of formula one motor racing (multiple letters) [11]. IN Lancet, 351.451-452.
    [BibTeX]
    @article{sadler1998tobacco[11],
    author = "Sadler, P and Luik, JC and Charlton, A and While, D and Kelly, S and Vaidya, SG and Vaidya, JS",
    journal = "Lancet",
    month = "Feb",
    pages = "451--452",
    title = "Tobacco sponsorship of formula one motor racing (multiple letters) [11]",
    volume = "351",
    year = "1998",
    issn = "0140-6736",
    issue = "9100",
    day = "7",
    }

  • Vaidya, J., Douek, M., Lokare, V., Secker-Walker, J., Fallowfield, L., Taylor, I. & Baum, M. (1998) Women prefer breast cancer prognosis expressed as chance of cure to 10 year survival , S65.
    [BibTeX]
    @inproceedings{vaidya1998womensurvival,
    author = "Vaidya, JS and Douek, M and Lokare, VG and Secker-Walker, J and Fallowfield, L and Taylor, I and Baum, M",
    booktitle = "European Journal of Cancer",
    pages = "S65",
    title = "Women prefer breast cancer prognosis expressed as chance of cure to 10 year survival",
    volume = "34 (Su",
    year = "1998",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "Cure Rates",
    keyword = "Life Expectancy",
    keyword = "Patient-Communication",
    keyword = "Prognosis",
    keyword = "Survival",
    keyword = "Survival Analysis",
    keyword = "women",
    }

  • Douek, M., Vaidya, J., Davidson, T., Lakhani, S., Hall-Craggs, M., Baum, M. & Taylor, I. (1998) Preoperative MRI does not infulence the amount of breast tissue excised in conservative cancer surgery , S45.
    [BibTeX]
    @inproceedings{douek1998preoperativesurgery,
    author = "Douek, M and Vaidya, JS and Davidson, T and Lakhani, SR and Hall-Craggs, MA and Baum, M and Taylor, I",
    booktitle = "",
    pages = "S45",
    title = "Preoperative MRI does not infulence the amount of breast tissue excised in conservative cancer surgery",
    year = "1998",
    keyword = "breast",
    keyword = "cancer",
    keyword = "Conservative",
    keyword = "MRI",
    keyword = "surgery",
    keyword = "tissue",
    }

  • Douek, M., Vaidya, J., Davidson, T., Lakhani, S., Hall-Craggs, M., Baum, M. & Taylor, I. (1998) Pre-operative MRI does not influence the amount of breast tissue excised in conservative cancer surgery , 45-46.
    [BibTeX]
    @inproceedings{douek1998pre-operativesurgery,
    author = "Douek, M and Vaidya, JS and Davidson, T and Lakhani, SR and Hall-Craggs, MA and Baum, M and Taylor, I",
    booktitle = "European Journal of Cancer",
    pages = "45--46",
    title = "Pre-operative MRI does not influence the amount of breast tissue excised in conservative cancer surgery",
    volume = "34",
    year = "1998",
    issue = "5",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "Breast Conservation Surgery",
    keyword = "cancer",
    keyword = "Conservative",
    keyword = "magnetic resonance imaging",
    keyword = "MRI",
    keyword = "surgery",
    keyword = "tissue",
    }

  • Vaidya, J. & Vaidya, S. (1998) US tobacco settlement. IN New England Journal of Medicine, 338.690-691.
    [BibTeX]
    @article{vaidya1998ussettlement,
    author = "Vaidya, JS and Vaidya, SG",
    journal = "New England Journal of Medicine",
    pages = "690--691",
    title = "US tobacco settlement",
    volume = "338",
    year = "1998",
    issn = "0028-4793",
    issue = "10",
    keyword = "Developing World",
    keyword = "Tobacco Eradication",
    keyword = "Tobacco Industry",
    }

  • Douek, M., Vaidya, J., Davidson, T., Lakhani, S., Blanchard, K., Baum, M. & Taylor, I. (1998) Pre-operative detection of breast cancer multicentricity with MRI , 71-71.
    [BibTeX]
    @inproceedings{douek1998pre-operativemri,
    author = "Douek, M and Vaidya, JS and Davidson, T and Lakhani, SR and Blanchard, K and Baum, M and Taylor, I",
    booktitle = "European Journal of Cancer",
    pages = "71--71",
    title = "Pre-operative detection of breast cancer multicentricity with MRI",
    volume = "34",
    year = "1998",
    issue = "5",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "magnetic resonance imaging",
    keyword = "MRI",
    keyword = "Multicentricity",
    }

  • Vaidya, J. & Mittra, I. (1998) The new method of expressing survival in cancer is popular (Author’s reply). IN BMJ (Clinical Research Ed.), 316.1092-1092.
    [BibTeX]
    @article{vaidya1998thereply,
    author = "Vaidya, JS and Mittra, I",
    journal = "BMJ (Clinical Research Ed.)",
    pages = "1092--1092",
    title = "The new method of expressing survival in cancer is popular (Author's reply)",
    volume = "316",
    year = "1998",
    issn = "0959-8138",
    keyword = "cancer",
    keyword = "Cure Rates",
    keyword = "Life Expectancy",
    keyword = "Patient-Communication",
    keyword = "Survival",
    keyword = "Survival Analysis",
    }

  • Badwe, R., Bhansali, M. & Vaidya, J. (1998) Unopposed oestrogen and breast cancer survival. IN Breast, 7.66-71.
    [BibTeX]
    @article{badwe1998unopposedsurvival,
    author = "Badwe, RA and Bhansali, MS and Vaidya, JS",
    journal = "Breast",
    pages = "66--71",
    title = "Unopposed oestrogen and breast cancer survival",
    volume = "7",
    year = "1998",
    issn = "0960-9776",
    issue = "2",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "Meta-analysis",
    keyword = "oestrogen",
    keyword = "Survival",
    keyword = "Timing of Surgery",
    }

  • Vaidya, S. & Vaidya, J. (1998) Tobacco sponsorship of Formula One motor racing. IN The Lancet, 351.452-452.
    [BibTeX] [Download PDF]
    @article{vaidya1998tobaccoracing,
    author = "Vaidya, SG and Vaidya, JS",
    journal = "The Lancet",
    pages = "452--452",
    title = "Tobacco sponsorship of Formula One motor racing",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/9482342",
    volume = "351",
    year = "1998",
    issn = "0140-6736",
    keyword = "Advertising \\& Sponsorship",
    keyword = "children",
    keyword = "Developing World",
    keyword = "Tobacco Industry",
    }

  • Vyas, J., Vaidya, J. & Chinoy, R. (1998) Prediction of nipple-areola involvement in breast cancer. IN European Journal of Surgical Oncology, 24.15-16. doi:10.1016/S0748-7983(98)80117-0
    [BibTeX] [Abstract]

    AimsTo find a pre-operative test for nipple and areola involvement in breast cancer.MethodsAreola?tumour distance was measured in 140 consecutive patients (median age 45, range: 23?83) undergoing a mastectomy. We analysed whether nipple and areola correlated with areola?tumour distance, tumour size, nodal status, perinodal involvement and lymphatic embolization.ResultsThe nipple was involved in 22 (16%) cases and this correlated with tumour size, number of lymph nodes, perinodal extension and presence of lymphatic emboli. In all these 22 cases, the tumour was within 2.5 cm of the areola. Tumour size, however, could not predict nipple involvement in tumours within 2.5 cm of the areolar edge.ConclusionsIn the one-fifth of cases where the tumour is over 2.5 cm from the areola, preserving the nipple and areola for reconstruction may be worthwhile. In remaining cases, some other predictive test for nipple involvement would be necessary.

    @article{vyas1998predictioncancer,
    author = "Vyas, JJ and Vaidya, JS and Chinoy, RF",
    journal = "European Journal of Surgical Oncology",
    note = "Imported via OAI, 7:29:01 2nd Sep 2005",
    pages = "15--16",
    title = "Prediction of nipple-areola involvement in breast cancer",
    volume = "24",
    year = "1998",
    abstract = "AimsTo find a pre-operative test for nipple and areola involvement in breast cancer.MethodsAreola?tumour distance was measured in 140 consecutive patients (median age 45, range: 23?83) undergoing a mastectomy. We analysed whether nipple and areola correlated with areola?tumour distance, tumour size, nodal status, perinodal involvement and lymphatic embolization.ResultsThe nipple was involved in 22 (16%) cases and this correlated with tumour size, number of lymph nodes, perinodal extension and presence of lymphatic emboli. In all these 22 cases, the tumour was within 2.5 cm of the areola. Tumour size, however, could not predict nipple involvement in tumours within 2.5 cm of the areolar edge.ConclusionsIn the one-fifth of cases where the tumour is over 2.5 cm from the areola, preserving the nipple and areola for reconstruction may be worthwhile. In remaining cases, some other predictive test for nipple involvement would be necessary.",
    doi = "10.1016/S0748-7983(98)80117-0",
    issn = "0748-7983",
    issue = "1",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "Conservative",
    keyword = "Nipple Involvement",
    }

  • Vaidya, J. & Baum, M. (1998) Spiral CT and lung cancer biology. IN The Lancet, 352.236-236.
    [BibTeX]
    @article{vaidya1998spiralbiology,
    author = "Vaidya, JS and Baum, M",
    journal = "The Lancet",
    pages = "236--236",
    title = "Spiral CT and lung cancer biology",
    volume = "352",
    year = "1998",
    issn = "0140-6736",
    keyword = "biology",
    keyword = "cancer",
    keyword = "CT",
    keyword = "lung",
    keyword = "Lung Cancer",
    keyword = "Natural History",
    keyword = "Over-Diagnosis",
    keyword = "screening",
    }

  • Vaidya, J., Baum, M., Tobias, J., D’Souza, D., Harte, K., Naidu, S., Mulvey, P., Sliski, A., Thomson, E. & Varricchione, T. (1998) Radiosurgery: A novel method of treatment of early breast cancer , 619-619.
    [BibTeX]
    @inproceedings{vaidya1998radiosurgery:cancer,
    author = "Vaidya, JS and Baum, M and Tobias, JS and D'Souza, D and Harte, K and Naidu, S and Mulvey, P and Sliski, A and Thomson, E and Varricchione, TR",
    booktitle = "European Journal of Surgical Oncology",
    pages = "619--619",
    title = "Radiosurgery: A novel method of treatment of early breast cancer",
    volume = "24",
    year = "1998",
    issue = "6",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "Intra-operative",
    keyword = "Local Recurrence",
    keyword = "Multicentricity",
    keyword = "Novel",
    keyword = "Radiosurgery",
    keyword = "treatment",
    }

  • Douek, M., Vaidya, J., Davidson, T., Lakhani, S., Hall-Craggs, M., Baum, M., Blanchand, K. & Taylor, I. (1998) Preoperative detection of breast cancer multicentricity with MRI , S71.
    [BibTeX]
    @inproceedings{douek1998preoperativemri,
    author = "Douek, M and Vaidya, JS and Davidson, T and Lakhani, SR and Hall-Craggs, MA and Baum, M and Blanchand, K and Taylor, I",
    booktitle = "",
    pages = "S71",
    title = "Preoperative detection of breast cancer multicentricity with MRI",
    year = "1998",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "MRI",
    keyword = "Multicentricity",
    }

  • Douek, M., Vaidya, J., Lakhani, S., Hall-Craggs, M., Baum, M. & Taylor, I. (1998) Can magnetic-resonance imaging help elucidate natural history of breast cancer multicentricity? [letter] [see comments]. IN The Lancet, 351.801-802.
    [BibTeX]
    @article{douek1998cancomments],
    author = "Douek, M and Vaidya, JS and Lakhani, SR and Hall-Craggs, MA and Baum, M and Taylor, I",
    journal = "The Lancet",
    pages = "801--802",
    title = "Can magnetic-resonance imaging help elucidate natural history of breast cancer multicentricity? [letter] [see comments]",
    volume = "351",
    year = "1998",
    issn = "0140-6736",
    issue = "9105",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "breast neoplasms",
    keyword = "cancer",
    keyword = "contrast media",
    keyword = "diagnosis",
    keyword = "diagnostic use",
    keyword = "Female",
    keyword = "gadolinium dtpa",
    keyword = "History",
    keyword = "Imaging",
    keyword = "magnetic resonance imaging",
    keyword = "Multicentricity",
    keyword = "pathology",
    keyword = "prospective studies",
    keyword = "sensitivity and specificity",
    }

  • Vaidya, J. & Baum, M. (1998) Clinical and biological implications of the Milan breast conservation trials. IN European Journal of Cancer, 34.1143-1144.
    [BibTeX]
    @article{vaidya1998clinicaltrials,
    author = "Vaidya, JS and Baum, M",
    journal = "European Journal of Cancer",
    pages = "1143--1144",
    title = "Clinical and biological implications of the Milan breast conservation trials",
    volume = "34",
    year = "1998",
    issn = "0959-8049",
    issue = "8",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "Clinical",
    keyword = "CONSERVATION",
    keyword = "Conservative Surgery",
    keyword = "Cosmesis",
    keyword = "Local Recurrence",
    keyword = "Milan",
    keyword = "Radiotherapy",
    keyword = "TRIAL",
    keyword = "TRIALS",
    }

  • Vaidya, J., Douek, M., Lokare, V., Secker-Walker, J., Fallowfield, L., Taylor, I. & Baum, M. (1998) Breast cancer prognosis expressed as \"chance of cure\" is preferable to \"10 year survival\" , 3882-3882.
    [BibTeX]
    @inproceedings{vaidya1998breastsurvival,
    author = "Vaidya, JS and Douek, M and Lokare, VG and Secker-Walker, J and Fallowfield, L and Taylor, I and Baum, M",
    booktitle = "Anticancer Research",
    pages = "3882--3882",
    title = "Breast cancer prognosis expressed as \"chance of cure\" is preferable to \"10 year survival\"",
    volume = "18",
    year = "1998",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "Cure Rates",
    keyword = "Life Expectancy",
    keyword = "Patient-Communication",
    keyword = "Prognosis",
    keyword = "Survival Analysis",
    }

  • Douek, M., Vaidya, J., Hall-Craggs, M., Lakhani, S. & Taylor, I. (1998) A classification of breast tumours based on subtracted contrast enhanced MRI , 351-351.
    [BibTeX] [Abstract]

    Meeting: British Association of Surgical Oncology, Liverpool, June 1998

    @inproceedings{douek1998amri,
    author = "Douek, M and Vaidya, JS and Hall-Craggs, MA and Lakhani, SR and Taylor, I",
    booktitle = "European Journal of Surgical Oncology",
    note = "ISSN: 0748-7983",
    pages = "351--351",
    title = "A classification of breast tumours based on subtracted contrast enhanced MRI",
    volume = "24",
    year = "1998",
    abstract = "Meeting: British Association of Surgical Oncology, Liverpool, June 1998",
    issue = "4",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "Classification",
    keyword = "MRI",
    keyword = "ONCOLOGY",
    keyword = "Tumours",
    }

  • Vaidya, J. & Baum, M. (1998) Paradoxes and provocations in breast cancer. IN Johnson, C. & Taylor, I. (Eds.), Recent Advances in Surgery 21..
    [BibTeX]
    @incollection{vaidya1998paradoxescancer,
    author = "Vaidya, JS and Baum, M",
    booktitle = "Recent Advances in Surgery 21",
    editor = "Johnson, CD and Taylor, I",
    number = "4",
    pages = "55--69",
    publisher = "Churchill Livingstone",
    school = "London",
    title = "Paradoxes and provocations in breast cancer",
    year = "1998",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "Natural History",
    keyword = "Paradoxes",
    keyword = "Recent Advances",
    keyword = "surgery",
    }

  • Vaidya, J., Douek, M., Kokare, V., Secker-Walker, J., Fallowfield, L., Taylor, I. & Baum, M. (1998) Communication of breast cancer prognosis: Women wish to know their chance of cure , 345-345.
    [BibTeX] [Abstract]

    Meeting: British Association of Surgical Oncology, Liverpool, June 1998

    @inproceedings{vaidya1998communicationcure,
    author = "Vaidya, JS and Douek, M and Kokare, VG and Secker-Walker, J and Fallowfield, L and Taylor, I and Baum, M",
    booktitle = "European Journal of Surgical Oncology",
    note = "ISSN: 0748-7983",
    pages = "345--345",
    title = "Communication of breast cancer prognosis: Women wish to know their chance of cure",
    volume = "24",
    year = "1998",
    abstract = "Meeting: British Association of Surgical Oncology, Liverpool, June 1998",
    issue = "4",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "communication",
    keyword = "ONCOLOGY",
    keyword = "Prognosis",
    keyword = "women",
    }

  • Douek, M., Vaidya, J., Davidson, T., Lakhani, S., Blanchard, K., Baum, M. & Taylor, I. (1998) Detection of breast cancer multicentricity with MRI , 3837-3837.
    [BibTeX]
    @inproceedings{douek1998detectionmri,
    author = "Douek, M and Vaidya, JS and Davidson, T and Lakhani, SR and Blanchard, K and Baum, M and Taylor, I",
    booktitle = "Anticancer Research",
    pages = "3837--3837",
    title = "Detection of breast cancer multicentricity with MRI",
    volume = "17",
    year = "1998",
    issue = "5C",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "magnetic resonance imaging",
    keyword = "MRI",
    keyword = "Multicentricity",
    }

  • Douek, M., Vaidya, J., Davidson, T., Lakhani, S., Hall-Craggs, M., Baum, M. & Taylor, I. (1998) MRI does not currently influence the amount of breast tissue excised in conservative breast surgery , 3838-3838.
    [BibTeX]
    @inproceedings{douek1998mrisurgery,
    author = "Douek, M and Vaidya, JS and Davidson, T and Lakhani, SR and Hall-Craggs, MA and Baum, M and Taylor, I",
    booktitle = "Anticancer Research",
    pages = "3838--3838",
    title = "MRI does not currently influence the amount of breast tissue excised in conservative breast surgery",
    volume = "17",
    year = "1998",
    issue = "5C",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "Breast Conservation Surgery",
    keyword = "Conservative",
    keyword = "Extent of Resection",
    keyword = "magnetic resonance imaging",
    keyword = "MRI",
    keyword = "surgery",
    keyword = "tissue",
    }

  • Douek, M., Vaidya, J., Lakhani, S., Blanchard, K., Hall-Craggs, M., Davidson, T., Baum, M. & Taylor, I. (1998) MRI in the detection of breast cancer multicentricity , 66-66.
    [BibTeX] [Abstract]

    Meeting: Association of Surgeons, Edinburgh, May 1998

    @inproceedings{douek1998mrimulticentricity,
    author = "Douek, M and Vaidya, JS and Lakhani, SR and Blanchard, K and Hall-Craggs, MA and Davidson, T and Baum, M and Taylor, I",
    booktitle = "British Journal of Surgery",
    note = "ISSN: 0007-1323",
    pages = "66--66",
    title = "MRI in the detection of breast cancer multicentricity",
    volume = "85 (Su",
    year = "1998",
    abstract = "Meeting: Association of Surgeons, Edinburgh, May 1998",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "MRI",
    keyword = "Multicentricity",
    keyword = "Surgeon",
    keyword = "Surgeons",
    }

  • Douek, M., Vaidya, J., Baum, M. & Taylor, I. (1998) Magnetic resonance imaging and breast cancer multicentricity. IN The Lancet, 352.652-653.
    [BibTeX]
    @article{douek1998magneticmulticentricity,
    author = "Douek, M and Vaidya, JS and Baum, M and Taylor, I",
    journal = "The Lancet",
    note = "ISSN: 01416736",
    pages = "652--653",
    title = "Magnetic resonance imaging and breast cancer multicentricity",
    volume = "352",
    year = "1998",
    issn = "0140-6736",
    issue = "9128",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "Imaging",
    keyword = "magnetic resonance imaging",
    keyword = "MRI",
    keyword = "Multicentricity",
    }

  • Vaidya, J. & Baum, M. (1998) Low-dose spiral computed tomography for lung-cancer screening (Letter). IN The Lancet, 352.236-236.
    [BibTeX]
    @article{vaidya1998low-doseletter,
    author = "Vaidya, JS and Baum, M",
    journal = "The Lancet",
    note = "ISSN: 0140-6736",
    pages = "236--236",
    title = "Low-dose spiral computed tomography for lung-cancer screening (Letter)",
    volume = "352",
    year = "1998",
    issn = "0140-6736",
    issue = "9123",
    keyword = "Letter",
    keyword = "Lung Cancer",
    keyword = "screening",
    }

  • Vaidya, J. (1998) Interpretation of the thrombosis prevention trial. IN The Lancet, 351.1204-1204.
    [BibTeX]
    @article{vaidya1998interpretationtrial,
    author = "Vaidya, JS",
    journal = "The Lancet",
    pages = "1204--1204",
    title = "Interpretation of the thrombosis prevention trial",
    volume = "351",
    year = "1998",
    issn = "0140-6736",
    keyword = "Confounding Factor",
    keyword = "prevention",
    keyword = "Primary Prevention",
    keyword = "Smoking",
    keyword = "TRIAL",
    keyword = "Waste of Resources",
    }

  • Vaidya, J. & Baum, M. (1997) Psion of the times.. IN Lancet, 350.1784. doi:10.1016/S0140-6736(05)63623-9
    [BibTeX] [Download PDF]
    @article{vaidya1997psiontimes.,
    author = "Vaidya, JS and Baum, M",
    journal = "Lancet",
    month = "Dec",
    organization = "ENGLAND",
    pages = "1784",
    title = "Psion of the times.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/9413502",
    volume = "350",
    year = "1997",
    doi = "10.1016/S0140-6736(05)63623-9",
    issn = "0140-6736",
    issue = "9093",
    keyword = "Breast Neoplasms",
    keyword = "Female",
    keyword = "Genes, BRCA1",
    keyword = "Humans",
    keyword = "Mathematical Computing",
    keyword = "Mutation",
    keyword = "Probability",
    language = "eng",
    pii = "S0140-6736(05)63623-9",
    day = "13",
    }

  • Vaidya, J. & Mittra, I. (1997) Fraction of normal remaining life: a new method for expressing survival in cancer. IN BREAST, 6.P934–P934.
    [BibTeX]
    @article{vaidya1997fractioncancer,
    address = "UCL, DEPT SURG, LONDON, ENGLAND and TATA MEM HOSP, DEPT SURG, BOMBAY 400012, MAHARASHTRA, INDIA",
    author = "Vaidya, JS and Mittra, I",
    journal = "BREAST",
    month = "Oct",
    pages = "P934--P934",
    publisher = "CHURCHILL LIVINGSTONE",
    title = "Fraction of normal remaining life: a new method for expressing survival in cancer",
    volume = "6",
    year = "1997",
    issn = "0960-9776",
    issue = "5",
    language = "EN",
    }

  • Gilson, E., Vaidya, J., Baum, M., Burke, W., Daly, M., Garber, J. & Botkin, J. (1997) Benefits and risks of screening mammography in women with BRCA1 and BRCA2 mutations. IN JAMA, 278.289-290.
    [BibTeX]
    @article{gilson1997benefitsmutations,
    author = "Gilson, E and Vaidya, JS and Baum, M and Burke, W and Daly, M and Garber, J and Botkin, J",
    journal = "JAMA",
    month = "Jul",
    note = "Imported via OAI, 7:29:01 2nd Sep 2005",
    pages = "289--290",
    title = "Benefits and risks of screening mammography in women with BRCA1 and BRCA2 mutations",
    volume = "278",
    year = "1997",
    issn = "0098-7484",
    issue = "4",
    day = "23",
    }

  • Vaidya, J. & Mittra, I. (1997) Fraction of normal remaining life span: a new method for expressing survival in cancer.. IN BMJ, 314.1682-1684.
    [BibTeX] [Download PDF]
    @article{vaidya1997fractioncancer.,
    author = "Vaidya, JS and Mittra, I",
    journal = "BMJ",
    month = "Jun",
    note = "PMCID: PMC2126869",
    organization = "ENGLAND",
    pages = "1682--1684",
    title = "Fraction of normal remaining life span: a new method for expressing survival in cancer.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/9193295",
    volume = "314",
    year = "1997",
    issn = "0959-8138",
    issue = "7095",
    keyword = "Humans",
    keyword = "Life Expectancy",
    keyword = "Neoplasms",
    keyword = "Survival Analysis",
    language = "eng",
    day = "7",
    }

  • Vaidya, J. (1997) Does CARET reduce lung cancer and heart disease?. IN Natl Med J India, 10.47.
    [BibTeX] [Download PDF]
    @article{vaidya1997doesdisease?,
    author = "Vaidya, JS",
    journal = "Natl Med J India",
    month = "Jan",
    organization = "INDIA",
    pages = "47",
    title = "Does CARET reduce lung cancer and heart disease?",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/9069714",
    volume = "10",
    year = "1997",
    issn = "0970-258X",
    issue = "1",
    keyword = "Heart Diseases",
    keyword = "Humans",
    keyword = "Lung Neoplasms",
    keyword = "Smoking",
    keyword = "Vitamin A",
    keyword = "Vitamin E",
    keyword = "beta Carotene",
    language = "eng",
    }

  • Badwe, R., Vaidya, J. & Bhansali, M. (1997) Multimodal therapy for esophageal adenocarcinoma.. IN N Engl J Med, 336.374-375. doi:10.1056/NEJM199701303360512
    [BibTeX] [Download PDF]
    @article{badwe1997multimodaladenocarcinoma.,
    author = "Badwe, RA and Vaidya, JS and Bhansali, MS",
    journal = "N Engl J Med",
    month = "Jan",
    organization = "UNITED STATES",
    pages = "374--375",
    title = "Multimodal therapy for esophageal adenocarcinoma.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/9011794",
    volume = "336",
    year = "1997",
    doi = "10.1056/NEJM199701303360512",
    issn = "0028-4793",
    issue = "5",
    keyword = "Adenocarcinoma",
    keyword = "Antineoplastic Combined Chemotherapy Protocols",
    keyword = "Carcinoma, Squamous Cell",
    keyword = "Combined Modality Therapy",
    keyword = "Esophageal Neoplasms",
    keyword = "Humans",
    keyword = "Meta-Analysis as Topic",
    keyword = "Randomized Controlled Trials as Topic",
    keyword = "Survival Analysis",
    language = "eng",
    day = "30",
    }

  • (1997) The Psion of times (computing breast cancer risk in clinic). IN The Lancet, .1784-1784.
    [BibTeX]
    @article{1997theclinic,
    author = "",
    editor = "Vaidya, JS and Baum, M",
    journal = "The Lancet",
    pages = "1784--1784",
    title = "The Psion of times (computing breast cancer risk in clinic)",
    year = "1997",
    issn = "0140-6736",
    issue = "350",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "RISK",
    }

  • Douek, M., Vaidya, J., Lakhani, S., Hall-Craggs, M., Baum, M. & Taylor, I. (1997) MRI in detection of breast cancer multicentricity , 591-591.
    [BibTeX]
    @inproceedings{douek1997mrimulticentricity,
    author = "Douek, M and Vaidya, JS and Lakhani, SR and Hall-Craggs, MA and Baum, M and Taylor, I",
    booktitle = "Eur J Surg Oncol",
    pages = "591--591",
    title = "MRI in detection of breast cancer multicentricity",
    volume = "23",
    year = "1997",
    issue = "6",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "detection",
    keyword = "MRI",
    }

  • Baum, M. & Vaidya, J. (1997) Molecular staging of cancer. IN The Lancet, 350.962.
    [BibTeX]
    @article{baum1997molecularcancer,
    author = "Baum, M and Vaidya, JS",
    journal = "The Lancet",
    pages = "962",
    title = "Molecular staging of cancer",
    volume = "350",
    year = "1997",
    issn = "0140-6736",
    issue = "9082",
    }

  • Vaidya, J., Mittra, I. & Baum, M. (1997) Local recurrence of breast cancer: new concepts about its biology and clinical relevance , 248-249.
    [BibTeX]
    @inproceedings{vaidya1997localrelevance,
    author = "Vaidya, JS and Mittra, I and Baum, M",
    booktitle = "Breast",
    pages = "248--249",
    title = "Local recurrence of breast cancer: new concepts about its biology and clinical relevance",
    volume = "6",
    year = "1997",
    issue = "4",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "CLINICAL",
    }

  • Vaidya, J., Mittra, I. & Baum, M. (1997) Local recurrence of breast cancer: new concepts about its biology and clinical relevance , 17-17.
    [BibTeX]
    @inproceedings{vaidya1997localrelevance,
    author = "Vaidya, JS and Mittra, I and Baum, M",
    booktitle = "Br J Cancer",
    pages = "17--17",
    title = "Local recurrence of breast cancer: new concepts about its biology and clinical relevance",
    year = "1997",
    issue = "76:sup",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "CLINICAL",
    }

  • (1997) Multicentricity and recurrence of breast cancer. IN The Lancet, .208-208.
    [BibTeX]
    @article{1997multicentricitycancer,
    author = "",
    editor = "Baum, M and Vaidya, JS",
    journal = "The Lancet",
    pages = "208--208",
    title = "Multicentricity and recurrence of breast cancer",
    year = "1997",
    issn = "0140-6736",
    issue = "349",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    }

  • (1997) Molecular diagnosis of cancer. IN The Lancet, .962-962.
    [BibTeX]
    @article{1997molecularcancer,
    author = "",
    editor = "Baum, M and Vaidya, JS",
    journal = "The Lancet",
    pages = "962--962",
    title = "Molecular diagnosis of cancer",
    year = "1997",
    issn = "0140-6736",
    issue = "350(90",
    keyword = "cancer",
    keyword = "DIAGNOSIS",
    keyword = "MOLECULAR",
    }

  • Vaidya, J., Baum, M. & Mittra, I. (1997) Multicentricity of breast cancer: new findings and their clinical and biological implications , 325-325.
    [BibTeX]
    @inproceedings{vaidya1997multicentricityimplications,
    author = "Vaidya, JS and Baum, M and Mittra, I",
    booktitle = "Breast",
    pages = "325--325",
    title = "Multicentricity of breast cancer: new findings and their clinical and biological implications",
    volume = "6",
    year = "1997",
    issue = "5",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "CLINICAL",
    }

  • Badwe, R., Vaidya, J. & Bhansali, M. (1997) Multimodality therapy for adenocarcinoma of esophagus (Letter). IN New Engl J Med, 336.374-375.
    [BibTeX]
    @article{badwe1997multimodalityletter,
    author = "Badwe, RA and Vaidya, JS and Bhansali, MB",
    journal = "New Engl J Med",
    pages = "374--375",
    title = "Multimodality therapy for adenocarcinoma of esophagus (Letter)",
    volume = "336",
    year = "1997",
    }

  • Vaidya, J. & Baum, M. (1997) Importance of non-linear mathematical modelling in hypothesis generation in cancer with special reference to breast cancer , 67-67.
    [BibTeX]
    @inproceedings{vaidya1997importancecancer,
    author = "Vaidya, JS and Baum, M",
    booktitle = "Clin Exper Metastasis",
    pages = "67--67",
    title = "Importance of non-linear mathematical modelling in hypothesis generation in cancer with special reference to breast cancer",
    volume = "Jan 19",
    year = "1997",
    issue = "15 (1)",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "HYPOTHESIS",
    keyword = "modelling",
    keyword = "nonlinear",
    keyword = "Reference",
    }

  • (1997) Multimodality therapy for adenocarcinoma of esophagus. IN New England Journal of Medicine, .374-375.
    [BibTeX]
    @article{1997multimodalityesophagus,
    author = "",
    editor = "Badwe, RA and Vaidya, JS and Bhansali, MS",
    journal = "New England Journal of Medicine",
    pages = "374--375",
    title = "Multimodality therapy for adenocarcinoma of esophagus",
    year = "1997",
    issn = "0028-4793",
    issue = "30 Jan",
    keyword = "cancer",
    keyword = "ESOPHAGUS",
    keyword = "multimodality therapy",
    keyword = "THERAPY",
    }

  • Badwe, R., Vaidya, J., Bhansali, M., Funk, E., Witte, J., Gaffney, P., Walsh, T., Kelly, A. & Hennsey, T. (1997) Multimodal therapy for esophageal adenocarcinoma [1] (multiple letters). IN New England Journal of Medicine, 336.374-376. doi:10.1056/NEJM199701303360512
    [BibTeX]
    @article{badwe1997multimodalletters,
    author = "Badwe, RA and Vaidya, JS and Bhansali, MS and Funk, EM and Witte, J and Gaffney, P and Walsh, TN and Kelly, A and Hennsey, TPJ",
    journal = "New England Journal of Medicine",
    pages = "374--376",
    title = "Multimodal therapy for esophageal adenocarcinoma [1] (multiple letters)",
    volume = "336",
    year = "1997",
    doi = "10.1056/NEJM199701303360512",
    issn = "0028-4793",
    issue = "5",
    }

  • (1997) Tamoxifen breast cancer prevention:the UK trials. IN Forum Trends in Experimental and Clinical Medicine, .107-111.
    [BibTeX]
    @article{1997tamoxifentrials,
    author = "",
    editor = "Baum, M and Vaidya, JS",
    journal = "Forum Trends in Experimental and Clinical Medicine",
    pages = "107--111",
    title = "Tamoxifen breast cancer prevention:the UK trials",
    year = "1997",
    issue = "7:1(su",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "tamoxifen",
    keyword = "TRIAL",
    keyword = "TRIALS",
    }

  • Baum, M., Vaidya, J., Mittra, I., Sacchini, V., Drew, P., Turnbull, L., Kerin, M., Carleton, P. & Fox, J. (1997) Multicentricity and recurrence of breast cancer (multiple letters) [15]. IN Lancet, 349.208-209.
    [BibTeX]
    @article{baum1997multicentricity[15],
    author = "Baum, M and Vaidya, JS and Mittra, I and Sacchini, V and Drew, PJ and Turnbull, LW and Kerin, MJ and Carleton, PJ and Fox, JN",
    journal = "Lancet",
    pages = "208--209",
    title = "Multicentricity and recurrence of breast cancer (multiple letters) [15]",
    volume = "349",
    year = "1997",
    issn = "0140-6736",
    issue = "9046",
    }

  • Anderson, T., Baum, M. & Vaidya, J. (1997) Molecular staging of cancer (multiple letters) [17]. IN Lancet, 350.962-962.
    [BibTeX]
    @article{anderson1997molecular[17],
    author = "Anderson, TJ and Baum, M and Vaidya, JS",
    journal = "Lancet",
    pages = "962--962",
    title = "Molecular staging of cancer (multiple letters) [17]",
    volume = "350",
    year = "1997",
    issn = "0140-6736",
    issue = "9082",
    }

  • (1997) Breast imaging and diagnosis (Rosen’s Breast Pathology). Review in ‘Dissecting Room’. IN The Lancet, .526-527.
    [BibTeX]
    @article{1997breastroom,
    author = "",
    editor = "Vaidya, JS",
    journal = "The Lancet",
    pages = "526--527",
    title = "Breast imaging and diagnosis (Rosen's Breast Pathology). Review in 'Dissecting Room'",
    year = "1997",
    issn = "0140-6736",
    issue = "350",
    keyword = "breast",
    keyword = "DIAGNOSIS",
    keyword = "imaging",
    keyword = "Pathology",
    keyword = "REVIEW",
    }

  • Vaidya, J. & Baum, M. (1997) Carcinoma of Breast: Current Controversies. IN Schein, M. & Wise, L. (Eds.), Crucial Controversies in Surgery 1998..
    [BibTeX]
    @incollection{vaidya1997carcinomacontroversies,
    author = "Vaidya, JS and Baum, M",
    booktitle = "Crucial Controversies in Surgery 1998",
    editor = "Schein, M and Wise, L",
    number = "5",
    pages = "81--92",
    publisher = "Karger-Landes Bioscience",
    school = "New York",
    title = "Carcinoma of Breast: Current Controversies",
    year = "1997",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "carcinoma",
    keyword = "SURGERY",
    }

  • (1997) Green tea and leukoplakia. IN The American Journal of Surgery, .552-555.
    [BibTeX]
    @article{1997greenleukoplakia,
    author = "",
    editor = "Vaidya, SG and Balentine, D and Blot, W and Bhonsle, RB and Chung, FL and Chigurupati, K and Gupta, PC and Vaidya, JS",
    journal = "The American Journal of Surgery",
    pages = "552--555",
    title = "Green tea and leukoplakia",
    year = "1997",
    issue = "174(5)",
    keyword = "Leukoplakia",
    }

  • Gilson, E., Vaidya, J., Baum, M., Burke, W., Daly, M., Garber, J., Botkin, J., Kahn, M., Lynch, P., McTiernan, A., Offit, K., Perlman, J., Petersen, G. & Thomson, E. (1997) Benefits and risks of screening mammography in women with BRCA1 and BRCA2 mutations [4] (multiple letters). IN Journal of the American Medical Association, 278.289-290.
    [BibTeX]
    @article{gilson1997benefitsletters,
    author = "Gilson, E and Vaidya, JS and Baum, M and Burke, W and Daly, M and Garber, J and Botkin, J and Kahn, MJE and Lynch, P and McTiernan, A and Offit, K and Perlman, JA and Petersen, G and Thomson, E",
    journal = "Journal of the American Medical Association",
    pages = "289--290",
    title = "Benefits and risks of screening mammography in women with BRCA1 and BRCA2 mutations [4] (multiple letters)",
    volume = "278",
    year = "1997",
    issn = "0098-7484",
    issue = "4",
    }

  • (1997) Benefits and risks of screening mammography in women with BRCA1 and BRAC2 mutations. IN JAMA, 278.290-290.
    [BibTeX]
    @article{1997benefitsmutations,
    author = "",
    editor = "Vaidya, JS and Baum, M",
    journal = "JAMA",
    pages = "290--290",
    title = "Benefits and risks of screening mammography in women with BRCA1 and BRAC2 mutations",
    volume = "278",
    year = "1997",
    issn = "0098-7484",
    issue = "4",
    keyword = "mammography",
    keyword = "MUTATION",
    keyword = "MUTATIONS",
    keyword = "RISK",
    keyword = "SCREENING",
    keyword = "WOMEN",
    }

  • Vaidya, J. (1997) Does CARET reduce lung cancer and heart disease? (Letter). IN Natl Med J Ind, 10.47.
    [BibTeX]
    @article{vaidya1997doesletter,
    author = "Vaidya, JS",
    journal = "Natl Med J Ind",
    pages = "47",
    title = "Does CARET reduce lung cancer and heart disease? (Letter)",
    volume = "10",
    year = "1997",
    issue = "1",
    }

  • (1997) Breast imaging and diagnosis (Diagnosis of Diseases of Breast). Review in ‘Dissecting Room’. IN The Lancet, .525-526.
    [BibTeX]
    @article{1997breastroom,
    author = "",
    editor = "Vaidya, JS",
    journal = "The Lancet",
    pages = "525--526",
    title = "Breast imaging and diagnosis (Diagnosis of Diseases of Breast). Review in 'Dissecting Room'",
    year = "1997",
    issn = "0140-6736",
    issue = "350",
    keyword = "breast",
    keyword = "DIAGNOSIS",
    keyword = "DISEASE",
    keyword = "imaging",
    keyword = "REVIEW",
    }

  • (1997) Evolution:Kasparov to IBM deeper blue. (Poem). IN BMA News Review, 23.10-10.
    [BibTeX]
    @article{1997evolution:kasparovpoem,
    author = "",
    editor = "Vaidya, JS",
    journal = "BMA News Review",
    pages = "10--10",
    title = "Evolution:Kasparov to IBM deeper blue. (Poem)",
    volume = "23",
    year = "1997",
    issue = "12",
    }

  • (1997) Fraction of normal remaining life: a new method to express survival in chronic diseases. IN BMJ (Clinical Research Ed.), .1682-1684.
    [BibTeX]
    @article{1997fractiondiseases,
    author = "",
    editor = "Vaidya, JS and Mittra, I",
    journal = "BMJ (Clinical Research Ed.)",
    pages = "1682--1684",
    title = "Fraction of normal remaining life: a new method to express survival in chronic diseases",
    year = "1997",
    issn = "0959-8138",
    issue = "314",
    keyword = "Chronic Disease",
    keyword = "DISEASE",
    keyword = "LIFE",
    keyword = "SURVIVAL",
    }

  • Vaidya, J., Latteier, J., Houghton, J., Mittra, I. & Baum, M. (1997) Fraction of normal remaining life: a new method of defining cure in early breast cancer , 1600-1600.
    [BibTeX]
    @inproceedings{vaidya1997fractioncancer,
    author = "Vaidya, JS and Latteier, J and Houghton, J and Mittra, I and Baum, M",
    booktitle = "Br J Surg",
    pages = "1600--1600",
    title = "Fraction of normal remaining life: a new method of defining cure in early breast cancer",
    year = "1997",
    issue = "84",
    keyword = "breast",
    keyword = "Breast cancer",
    keyword = "cancer",
    keyword = "LIFE",
    }

  • Vaidya, J. & Mittra, I. (1997) Fraction of normal remaining life: a new method for expressing survival in cancer , 338-339.
    [BibTeX]
    @inproceedings{vaidya1997fractioncancer,
    author = "Vaidya, JS and Mittra, I",
    booktitle = "Breast",
    pages = "338--339",
    title = "Fraction of normal remaining life: a new method for expressing survival in cancer",
    volume = "6",
    year = "1997",
    issue = "5",
    keyword = "cancer",
    keyword = "LIFE",
    keyword = "SURVIVAL",
    }

  • Vaidya, J., Latteier, J., Mittra, I., Houghton, J. & Baum, M. (1997) Fraction of normal remaining life: a new method of defining cure in early breast cancer , 243-243.
    [BibTeX]
    @inproceedings{vaidya1997fractioncancer,
    author = "Vaidya, JS and Latteier, J and Mittra, I and Houghton, J and Baum, M",
    booktitle = "The Breast",
    pages = "243--243",
    title = "Fraction of normal remaining life: a new method of defining cure in early breast cancer",
    volume = "6",
    year = "1997",
    issue = "4",
    keyword = "defining cure",
    keyword = "Early Breast Cancer",
    }

  • Vaidya, J. & Sacks, N. (1996) Should breast reduction surgery be rationed? Only a third of women studied completed both questionnaires.. IN BMJ, 313.1478-1479.
    [BibTeX] [Download PDF]
    @article{vaidya1996shouldquestionnaires.,
    author = "Vaidya, JS and Sacks, N",
    journal = "BMJ",
    month = "Dec",
    note = "PMCID: PMC2352995",
    organization = "ENGLAND",
    pages = "1478--1479",
    title = "Should breast reduction surgery be rationed? Only a third of women studied completed both questionnaires.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/8973244",
    volume = "313",
    year = "1996",
    issn = "0959-8138",
    issue = "7070",
    keyword = "Breast Diseases",
    keyword = "Data Collection",
    keyword = "Female",
    keyword = "Health Care Rationing",
    keyword = "Humans",
    keyword = "Mammaplasty",
    keyword = "Questionnaires",
    language = "eng",
    day = "7",
    }

  • Divatia, J., Vaidya, J., Badwe, R. & Hawaldar, R. (1996) Omission of nitrous oxide during anesthesia reduces the incidence of postoperative nausea and vomiting: a meta-analysis. IN Anesthesiology, 85.1055-1062.
    [BibTeX] [Abstract]

    Background: Postoperative nausea and vomiting are important causes of morbidity after general anesthesia. Nitrous oxide has been implicated as an emetogenic agent in many studies. However, several other trials have failed to sustain this claim. The authors tried to resolve this issue through a meta-analysis of randomized controlled trials comparing the incidence of postoperative nausea and vomiting after anesthesia with or without nitrous oxide.Methods: Of 37 published studies retrieved by a search of articles indexed on the MEDLINE database from 1966 to 1994, 24 studies (26 trials) with distinct nitrous-oxide and non-nitrous oxide groups were eligible for the meta-analysis. The pooled odds ratio and relative risk were calculated. Post hoc subgroup analysis was also performed to qualify the result.Results: The pooled odds ratio was 0.63 (0.53 to 0.75). Omission of nitrous oxide reduced the risk for postoperative nausea and vomiting by 28% (18% to 37%). In the subgroup analysis, the maximal effect of omission of nitrous oxide was seen in female patients. In patients undergoing abdominal surgery and general surgical procedures, the effect of omission of nitrous oxide, although in the same direction, was not significant.Conclusion: Omission of nitrous oxide reduced the odds of postoperative nausea and vomiting by 37%, a reduction in risk of 28%.

    @article{divatia1996omissionmeta-analysis,
    author = "Divatia, JV and Vaidya, JS and Badwe, RA and Hawaldar, RW",
    journal = "Anesthesiology",
    month = "Nov",
    note = "Imported via OAI, 7:29:01 8th Sep 2005",
    pages = "1055--1062",
    title = "Omission of nitrous oxide during anesthesia reduces the incidence of postoperative nausea and vomiting: a meta-analysis",
    volume = "85",
    year = "1996",
    abstract = "Background: Postoperative nausea and vomiting are important causes of morbidity after general anesthesia. Nitrous oxide has been implicated as an emetogenic agent in many studies. However, several other trials have failed to sustain this claim. The authors tried to resolve this issue through a meta-analysis of randomized controlled trials comparing the incidence of postoperative nausea and vomiting after anesthesia with or without nitrous oxide.Methods: Of 37 published studies retrieved by a search of articles indexed on the MEDLINE database from 1966 to 1994, 24 studies (26 trials) with distinct nitrous-oxide and non-nitrous oxide groups were eligible for the meta-analysis. The pooled odds ratio and relative risk were calculated. Post hoc subgroup analysis was also performed to qualify the result.Results: The pooled odds ratio was 0.63 (0.53 to 0.75). Omission of nitrous oxide reduced the risk for postoperative nausea and vomiting by 28% (18% to 37%). In the subgroup analysis, the maximal effect of omission of nitrous oxide was seen in female patients. In patients undergoing abdominal surgery and general surgical procedures, the effect of omission of nitrous oxide, although in the same direction, was not significant.Conclusion: Omission of nitrous oxide reduced the odds of postoperative nausea and vomiting by 37%, a reduction in risk of 28%.",
    issn = "0003-3022",
    issue = "5",
    }

  • Vaidya, J. (1996) A new noose type non-slip surgical knot that can be tied by one hand. IN Contemporary Surgery, 49.294.
    [BibTeX]
    @article{vaidya1996ahand,
    author = "Vaidya, JS",
    journal = "Contemporary Surgery",
    month = "Nov",
    organization = "USA",
    pages = "294",
    title = "A new noose type non-slip surgical knot that can be tied by one hand",
    volume = "49",
    year = "1996",
    issue = "5",
    }

  • Vaidya, S., Naik, U. & Vaidya, J. (1996) Effect of sports sponsorship by tobacco companies on children’s experimentation with tobacco. IN BMJ (Clinical Research Ed.), 313.400.
    [BibTeX] [Abstract]

    Tobacco companies often seem to direct their advertising campaigns at adolescents–for example, the campaign using the cartoon character Joe Camel. These advertisements are thought to influence adolescents’ perceptions and behaviour, and sponsorship of sports events by tobacco companies may have the same effect. We studied the effect of sports sponsorship on children’s experimentation with tobacco.

    @article{vaidya1996effecttobacco,
    author = "Vaidya, SG and Naik, UD and Vaidya, JS",
    journal = "BMJ (Clinical Research Ed.)",
    month = "Aug",
    note = "Imported via OAI, 7:29:01 2nd Sep 2005",
    pages = "400",
    title = "Effect of sports sponsorship by tobacco companies on children's experimentation with tobacco",
    volume = "313",
    year = "1996",
    abstract = "Tobacco companies often seem to direct their advertising campaigns at adolescents--for example, the campaign using the cartoon character Joe Camel. These advertisements are thought to influence adolescents' perceptions and behaviour, and sponsorship of sports events by tobacco companies may have the same effect. We studied the effect of sports sponsorship on children's experimentation with tobacco.",
    issn = "0959-8138",
    issue = "7054",
    day = "17",
    }

  • Vaidya, J. (1996) The HIV-tobacco theorem.. IN Natl Med J India, 9.144.
    [BibTeX] [Download PDF]
    @article{vaidya1996thetheorem.,
    author = "Vaidya, JS",
    journal = "Natl Med J India",
    month = "May",
    organization = "INDIA",
    pages = "144",
    title = "The HIV-tobacco theorem.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/8664834",
    volume = "9",
    year = "1996",
    issn = "0970-258X",
    issue = "3",
    keyword = "HIV Infections",
    keyword = "Humans",
    keyword = "Needlestick Injuries",
    keyword = "Probability",
    keyword = "Smoking",
    language = "eng",
    }

  • Vaidya, J., Vyas, J., Thakur, M., Khandelwal, K. & Mittra, I. (1996) Role of ultrasonography to detect axillary node involvement in operable breast cancer. IN European Journal of Surgical Oncology, 22.140-143. doi:10.1016/S0748-7983(96)90593-4
    [BibTeX] [Abstract]

    Prompted by the concern about unnecessary axillary dissections, we prospectively studied the accuracy of clinical examination (CE) and conventional ultrasonography (USG, 7.5 MHz), to diagnose pre-operatively metastatic axillary lymph nodes in 200 operable breast cancer patients. USG had higher specificity (90% vs 77

    @article{vaidya1996rolecancer,
    author = "Vaidya, JS and Vyas, JJ and Thakur, MH and Khandelwal, KC and Mittra, I",
    journal = "European Journal of Surgical Oncology",
    month = "Apr",
    note = "Imported via OAI, 7:29:01 2nd Sep 2005",
    pages = "140--143",
    title = "Role of ultrasonography to detect axillary node involvement in operable breast cancer",
    volume = "22",
    year = "1996",
    abstract = "Prompted by the concern about unnecessary axillary dissections, we prospectively studied the accuracy of clinical examination (CE) and conventional ultrasonography (USG, 7.5 MHz), to diagnose pre-operatively metastatic axillary lymph nodes in 200 operable breast cancer patients. USG had higher specificity (90% vs 77%, P=0.025) and higher positive predictive value (ppv=90% vs 76%, P=0.02) than CE. Together, CE + USG had higher sensitivity (82% vs 58%, P=0.00005) and higher negative predictive value (npv = 76% vs 58%, P=0.008) than CE alone. In women <45 years, CE + USG had higher sensitivity (91% vs 76%, P=0.037) and npv (89% vs 67%, P=0.018) than in older women. The sensitivity and npv of CE + USG to detect >1 positive node were 97% (for both) in women <45 years compared to 81% and 79% in older women. The high sensitivity of CE + USG (82% for the whole group) is probably due to the higher proportion of young women (median age=45) in our population. It suggests that using CE + USG to avoid axillary dissection in some patients is feasible.",
    doi = "10.1016/S0748-7983(96)90593-4",
    issn = "0748-7983",
    issue = "2",
    }

  • Vaidya, J. (1996) A new test for distinguishing direct and indirect inguinal hernia. IN Contemporary Surgery, 48.225.
    [BibTeX]
    @article{vaidya1996ahernia,
    author = "Vaidya, JS",
    journal = "Contemporary Surgery",
    month = "Apr",
    organization = "USA",
    pages = "225",
    title = "A new test for distinguishing direct and indirect inguinal hernia",
    volume = "48",
    year = "1996",
    issue = "4",
    }

  • Badwe, R. & Vaidya, J. (1996) Haematogenous dissemination of prostate epithelial cells during surgery (vol 347, pg 325, 1996). IN LANCET, 347.842-842.
    [BibTeX]
    @article{badwe1996haematogenous1996,
    author = "Badwe, RA and Vaidya, JS",
    journal = "LANCET",
    month = "Mar",
    pages = "842--842",
    publisher = "LANCET LTD",
    title = "Haematogenous dissemination of prostate epithelial cells during surgery (vol 347, pg 325, 1996)",
    volume = "347",
    year = "1996",
    issn = "0140-6736",
    issue = "9004",
    language = "EN",
    day = "23",
    }

  • Badwe, R. & Vaidya, J. (1996) Haematogenous dissemination of prostate epithelial cells during surgery.. IN Lancet, 347.325-326.
    [BibTeX] [Download PDF]
    @article{badwe1996haematogenoussurgery.,
    author = "Badwe, RA and Vaidya, JS",
    journal = "Lancet",
    month = "Feb",
    organization = "ENGLAND",
    pages = "325--326",
    title = "Haematogenous dissemination of prostate epithelial cells during surgery.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/8569380",
    volume = "347",
    year = "1996",
    issn = "0140-6736",
    issue = "8997",
    keyword = "Age Factors",
    keyword = "Female",
    keyword = "Humans",
    keyword = "Male",
    keyword = "Middle Aged",
    keyword = "Neoplasm Seeding",
    keyword = "Neoplasms",
    keyword = "Neoplastic Cells, Circulating",
    keyword = "Randomized Controlled Trials as Topic",
    keyword = "Time Factors",
    language = "eng",
    day = "3",
    }

  • Vaidya, J. (1996) Wills makes Confession. IN Economic Times, 339.7.
    [BibTeX]
    @article{vaidya1996willsconfession,
    author = "Vaidya, JS",
    edition = "35",
    journal = "Economic Times",
    month = "Feb",
    pages = "7",
    title = "Wills makes Confession",
    volume = "339",
    year = "1996",
    day = "9",
    }

  • Vaidya, J. (1996) Smokeless World Cup. IN Times of India, 11.14.
    [BibTeX]
    @article{vaidya1996smokelesscup,
    author = "Vaidya, JS",
    edition = "159",
    journal = "Times of India",
    month = "Jan",
    pages = "14",
    title = "Smokeless World Cup",
    volume = "11",
    year = "1996",
    day = "12",
    }

  • Vaidya, J., Sacks, N., Somerville, M., Radford, G., Hews, N., Fitzpatrick, R., Klassen, A., Jenkinson, C. & Goodacre, T. (1996) Should breast reduction surgery be rationed? [4]. IN British Medical Journal, 313.1478-1479.
    [BibTeX]
    @article{vaidya1996should[4],
    author = "Vaidya, JS and Sacks, N and Somerville, M and Radford, G and Hews, N and Fitzpatrick, R and Klassen, A and Jenkinson, C and Goodacre, T",
    journal = "British Medical Journal",
    pages = "1478--1479",
    title = "Should breast reduction surgery be rationed? [4]",
    volume = "313",
    year = "1996",
    issn = "0959-8146",
    issue = "7070",
    }

  • Vaidya, J., Vyas, J., Mittra, I., Thakur, M. & Khandelwal, K. (1996) Role of ultrasonography to detect axillary node involvement in operable breast cancer. IN European Journal of Surgical Oncology, 22.140-143. doi:10.1016/S0748-7983(96)90593-4
    [BibTeX] [Abstract]

    Prompted by the concern about unnecessary axillary dissections, we prospectively studied the accuracy of clinical examination (CE) and conventional ultrasonography (USG, 7.5 MHz), to diagnose pre-operatively metastatic axillary lymph nodes in 200 operable breast cancer patients. USG had higher specificity (90% vs 77

    @article{vaidya1996rolecancer,
    author = "Vaidya, JS and Vyas, JJ and Mittra, I and Thakur, MH and Khandelwal, KC",
    journal = "European Journal of Surgical Oncology",
    pages = "140--143",
    title = "Role of ultrasonography to detect axillary node involvement in operable breast cancer",
    volume = "22",
    year = "1996",
    abstract = "Prompted by the concern about unnecessary axillary dissections, we prospectively studied the accuracy of clinical examination (CE) and conventional ultrasonography (USG, 7.5 MHz), to diagnose pre-operatively metastatic axillary lymph nodes in 200 operable breast cancer patients. USG had higher specificity (90% vs 77%, P = 0.025) anti higher positive predictive value (ppv = 90% vs 76%, P = 0.02) than CE. Together, CE + USG had higher sensitivity (82% vs 58%, P = 0.00005) and higher negative predictive value (npv = 76% vs 58%, P = 0.008) than CE alone, In women < 45 years, CE + USG had higher sensitivity (91% vs 76%, P = 0.037) and npv (89% vs 67%, P = 0.018) than in older women, The sensitivity and npv of CE + USG to detect > 1 positive node were 97% (for both) in women < 35 years compared to 81% and 79% in older women. The high sensitivity of CE + USG (82% for the whole group) is probably due to the higher proportion of young women (median age = 45) in our population. It suggests that using CE + USG to avoid axillary dissection in some patients is feasible.",
    doi = "10.1016/S0748-7983(96)90593-4",
    issn = "0748-7983",
    issue = "2",
    }

  • Vaidya, J. (1996) The concept of scientific holism. IN Natl Med J Ind., 9.299-300.
    [BibTeX]
    @article{vaidya1996theholism,
    author = "Vaidya, JS",
    journal = "Natl Med J Ind.",
    pages = "299--300",
    title = "The concept of scientific holism",
    volume = "9",
    year = "1996",
    issue = "6",
    }

  • Vaidya, J., Vyas, J., Chinoy, R., Merchant, N., Sharma, O. & Mittra, I. (1996) Multicentricity of breast cancer: whole-organ analysis and clinical implications. IN British Journal of Cancer, 74.820-824.
    [BibTeX] [Abstract]

    We studied the spatial relationship within the breast between multicentric foci (MCF) and the primary tumour in 30 modified radical mastectomy specimens using Egan’s correlated pathological-radiological method using 5 mm slices of the whole breast. The relative positions within the breast of the primary tumour and MCF were used to calculate the relative distribution of primary tumour and MCF in the four quadrants of the breast and the per cent breast volume that would be required to be excised to include all MCF. Nineteen (63%) breast harboured MCF. The relative distribution of primary tumour and MCF in the four breast quadrants was significantly different (P = 0.034). MCF were present beyond the index quadrant (25% of breast volume including the tumour) in as many as 79% (15/19) of breasts that harboured MCF; and in half the cases (15/30) when all breast were considered. This is in variance with the suggestion put forward previously that MCF are contained within the index quadrant in 90% of cases. Although the number of patients in the present series is small, the probability of our finding being due to play of chance is 1 in 1500. In a large series of breast conservation studies > 90% of early breast recurrences have been round to occur in the index quadrant. Our finding, that in half the patients (15/30) MCF are present in quadrants other than the index quadrant, suggests that MCF do not give rise to early breast recurrence.

    @article{vaidya1996multicentricityimplications,
    author = "Vaidya, JS and Vyas, JJ and Chinoy, RF and Merchant, N and Sharma, OP and Mittra, I",
    journal = "British Journal of Cancer",
    note = "Imported via OAI, 7:29:01 8th Sep 2005",
    pages = "820--824",
    title = "Multicentricity of breast cancer: whole-organ analysis and clinical implications",
    volume = "74",
    year = "1996",
    abstract = "We studied the spatial relationship within the breast between multicentric foci (MCF) and the primary tumour in 30 modified radical mastectomy specimens using Egan's correlated pathological-radiological method using 5 mm slices of the whole breast. The relative positions within the breast of the primary tumour and MCF were used to calculate the relative distribution of primary tumour and MCF in the four quadrants of the breast and the per cent breast volume that would be required to be excised to include all MCF. Nineteen (63%) breast harboured MCF. The relative distribution of primary tumour and MCF in the four breast quadrants was significantly different (P = 0.034). MCF were present beyond the index quadrant (25% of breast volume including the tumour) in as many as 79% (15/19) of breasts that harboured MCF; and in half the cases (15/30) when all breast were considered. This is in variance with the suggestion put forward previously that MCF are contained within the index quadrant in 90% of cases. Although the number of patients in the present series is small, the probability of our finding being due to play of chance is 1 in 1500. In a large series of breast conservation studies > 90% of early breast recurrences have been round to occur in the index quadrant. Our finding, that in half the patients (15/30) MCF are present in quadrants other than the index quadrant, suggests that MCF do not give rise to early breast recurrence.",
    issn = "0007-0920",
    issue = "5",
    }

  • Vaidya, J. & Sacks, N. (1996) Should breast reduction surgery be rationed? Only a third of women completed both questionnaires. IN BMJ, 313.1278-1279.
    [BibTeX]
    @article{vaidya1996shouldquestionnaires,
    author = "Vaidya, JS and Sacks, N",
    journal = "BMJ",
    pages = "1278--1279",
    title = "Should breast reduction surgery be rationed? Only a third of women completed both questionnaires",
    volume = "313",
    year = "1996",
    issn = "0959-8138",
    }

  • Bhansali, M., Vaidya, J., Bhatt, R., Patil, P., Badwe, R. & Desai, P. (1996) Chemotherapy for carcinoma of the esophagus: a comparison of evidence from meta-analyses of randomized trials and of historical control studies. IN Annals of Oncology, 7.355-359.
    [BibTeX] [Abstract]

    Background: Chemotherapy (CT) has been used as an adjunct to local treatment (surgery or radiotherapy) in esophageal carcinoma. A meta-analysis of all published randomized clinical trials and historical control studies which have used cisplatinum-based combination CT was carried out to asses the effect of chemotherapy on survival for esophageal cancer. Materials and methods: A computer-based literature search was performed for the period from January 1988 to March 1995 using the index terms ‘Esophageal neoplasms’ and ‘Chemotherapy: The frame of reference was further narrowed to include only cisplatinum-based combination chemotherapy. Twelve randomized clinical trials (RCT) and eight historical control (HC) studies were included in the meta-analysis. Results: In the overview of HC studies a highly significant reduction in odds of death with CT was observed (68% ± 8% OR = 0.32, 95% CI 0.24-0.42). On the other hand, the overview of RCTs showed a relative reduction in odds of death for the CT group of 4.2% ± 23.7% (OR = 0.96, 95% CI 0.75-1.22). Conclusions: There was a gross overestimation of treatment effect in the studies using HC as compared to RCTs, despite the use of cisplatinum-based chemotherapy in both groups. The meta-analysis of RCTs reveal no significant survival benefit from cisplatinum-based adjuvant/neoadjuvant chemotherapy in esophageal cancer.

    @article{bhansali1996chemotherapystudies,
    author = "Bhansali, MS and Vaidya, JS and Bhatt, RG and Patil, PK and Badwe, RA and Desai, PB",
    journal = "Annals of Oncology",
    note = "Imported via OAI, 7:29:01 8th Sep 2005",
    pages = "355--359",
    title = "Chemotherapy for carcinoma of the esophagus: a comparison of evidence from meta-analyses of randomized trials and of historical control studies",
    volume = "7",
    year = "1996",
    abstract = "Background: Chemotherapy (CT) has been used as an adjunct to local treatment (surgery or radiotherapy) in esophageal carcinoma. A meta-analysis of all published randomized clinical trials and historical control studies which have used cisplatinum-based combination CT was carried out to asses the effect of chemotherapy on survival for esophageal cancer. Materials and methods: A computer-based literature search was performed for the period from January 1988 to March 1995 using the index terms 'Esophageal neoplasms' and 'Chemotherapy: The frame of reference was further narrowed to include only cisplatinum-based combination chemotherapy. Twelve randomized clinical trials (RCT) and eight historical control (HC) studies were included in the meta-analysis. Results: In the overview of HC studies a highly significant reduction in odds of death with CT was observed (68% ± 8% OR = 0.32, 95% CI 0.24-0.42). On the other hand, the overview of RCTs showed a relative reduction in odds of death for the CT group of 4.2% ± 23.7% (OR = 0.96, 95% CI 0.75-1.22). Conclusions: There was a gross overestimation of treatment effect in the studies using HC as compared to RCTs, despite the use of cisplatinum-based chemotherapy in both groups. The meta-analysis of RCTs reveal no significant survival benefit from cisplatinum-based adjuvant/neoadjuvant chemotherapy in esophageal cancer.",
    issn = "0923-7534",
    issue = "4",
    }

  • Vaidya, J. (1996) HIV-Tobacco Theorem A smoker faces the same risk of death as a person who pricks himself 3 times a year with a HIV +ve needle- 50% over 40 years.. IN Natl Med J Ind, 9.144.
    [BibTeX]
    @article{vaidya1996hiv-tobaccoyears.,
    author = "Vaidya, JS",
    journal = "Natl Med J Ind",
    pages = "144",
    title = "HIV-Tobacco Theorem
    A smoker faces the same risk of death as a person who pricks himself 3 times a year with a HIV +ve needle- 50% over 40 years.",
    volume = "9",
    year = "1996",
    issue = "3",
    }

  • Vaidya, J. & Vaidya, S. (1996) Diastolic blood pressure can be reliably recorded by palpation. IN Arch Int Med., 156.1586.
    [BibTeX]
    @article{vaidya1996diastolicpalpation,
    author = "Vaidya, JS and Vaidya, SJ",
    journal = "Arch Int Med.",
    pages = "1586",
    title = "Diastolic blood pressure can be reliably recorded by palpation",
    volume = "156",
    year = "1996",
    }

  • Badwe, R. & Vaidya, J. (1996) Error: Haematogenous dissemination of prostate epithelial cells during surgery (The Lancet (Feb. 3) (325)). IN Lancet, 347.842-842.
    [BibTeX]
    @article{badwe1996error:325,
    author = "Badwe, RA and Vaidya, JS",
    journal = "Lancet",
    pages = "842--842",
    title = "Error: Haematogenous dissemination of prostate epithelial cells during surgery (The Lancet (Feb. 3) (325))",
    volume = "347",
    year = "1996",
    issn = "0140-6736",
    issue = "9004",
    }

  • Badwe, R. & Vaidya, J. (1996) Haematogenous dissemination of prostate epithelial cells during surgery – Does surgery disseminate or accelerate cancer (Letter). IN The Lancet, 347.325-326.
    [BibTeX]
    @article{badwe1996haematogenousletter,
    author = "Badwe, RA and Vaidya, JS",
    journal = "The Lancet",
    pages = "325--326",
    title = "Haematogenous dissemination of prostate epithelial cells during surgery - Does surgery disseminate or accelerate cancer (Letter)",
    volume = "347",
    year = "1996",
    issn = "0140-6736",
    }

  • Vaidya, J. (1995) New bedside test to assess feasibility of primary closure after mastectomy for locally advanced breast cancer.. IN J Surg Oncol, 60.286.
    [BibTeX] [Download PDF]
    @article{vaidya1995newcancer.,
    author = "Vaidya, JS",
    journal = "J Surg Oncol",
    month = "Dec",
    organization = "UNITED STATES",
    pages = "286",
    title = "New bedside test to assess feasibility of primary closure after mastectomy for locally advanced breast cancer.",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/8551741",
    volume = "60",
    year = "1995",
    issn = "0022-4790",
    issue = "4",
    keyword = "Breast Neoplasms",
    keyword = "Female",
    keyword = "Humans",
    keyword = "Mastectomy",
    language = "eng",
    }

  • Vaidya, J. (1995) Cost of human life for Wills (a tobacco company) sponsorship (of World Cup). IN Economic Times, 295.6.
    [BibTeX]
    @article{vaidya1995costcup,
    author = "Vaidya, JS",
    edition = "35",
    journal = "Economic Times",
    month = "Dec",
    pages = "6",
    title = "Cost of human life for Wills (a tobacco company) sponsorship (of World Cup)",
    volume = "295",
    year = "1995",
    day = "21",
    }

  • VAIDYA, J., Sanjay, A. & Roshni, F. (1995) Primary malignant melanoma of the scrotum: a case report. IN Ind J Urol, 12.26-27.
    [BibTeX]
    @article{vaidya1995primaryreport,
    author = "VAIDYA, J and Sanjay, AP and Roshni, FC",
    journal = "Ind J Urol",
    month = "Sep",
    organization = "India",
    pages = "26--27",
    school = "India",
    title = "Primary malignant melanoma of the scrotum: a case report",
    volume = "12",
    year = "1995",
    issue = "1",
    publicationstatus = "published",
    }

  • Vaidya, J. (1995) Merchants of Death (tobacco traders). IN Times of India, 158.14.
    [BibTeX]
    @article{vaidya1995merchantstraders,
    author = "Vaidya, JS",
    journal = "Times of India",
    pages = "14",
    title = "Merchants of Death (tobacco traders)",
    volume = "158",
    year = "1995",
    issue = "260",
    }

  • Vaidya, S. & Vaidya, J. (1995) Report of UICC Tobacco Control Advocacy Training Workshop: 12-14 February, 1995 .
    [BibTeX]
    @techreport{vaidya1995report1995,
    author = "Vaidya, SG and Vaidya, JS",
    institution = "",
    number = "1",
    pages = "180",
    title = "Report of UICC Tobacco Control Advocacy Training Workshop: 12-14 February, 1995",
    year = "1995",
    }

  • Vaidya, J. & Dhume, R. (1994) Influence of lateral posture on sweating: does posture alter the sympathetic outflow to the sweat glands?. IN Indian J Physiol Pharmacol, 38.319-322.
    [BibTeX] [Abstract] [Download PDF]

    Our unpublished observation that a lateral decubitus posture influences the pattern of sweating was systematically tested by measuring galvanic skin resistance (GSR). Changes in the GSR between two electrodes placed on skin was used to quantify the degree of sweating. In the lateral posture, sweating is inhibited on the lower half and stimulated on the upper half and reversal of the lateral posture induces sweating on the opposite half of the body. This observation suggests that the autonomic nervous system is controlled at least in part, by body posture.

    @article{vaidya1994influenceglands,
    author = "Vaidya, JS and Dhume, RA",
    journal = "Indian J Physiol Pharmacol",
    month = "Oct",
    organization = "INDIA",
    pages = "319--322",
    title = "Influence of lateral posture on sweating: does posture alter the sympathetic outflow to the sweat glands?",
    url = "http://www.ncbi.nlm.nih.gov/pubmed/7883305",
    volume = "38",
    year = "1994",
    abstract = "Our unpublished observation that a lateral decubitus posture influences the pattern of sweating was systematically tested by measuring galvanic skin resistance (GSR). Changes in the GSR between two electrodes placed on skin was used to quantify the degree of sweating. In the lateral posture, sweating is inhibited on the lower half and stimulated on the upper half and reversal of the lateral posture induces sweating on the opposite half of the body. This observation suggests that the autonomic nervous system is controlled at least in part, by body posture.",
    issn = "0019-5499",
    issue = "4",
    keyword = "Adolescent",
    keyword = "Adult",
    keyword = "Child",
    keyword = "Galvanic Skin Response",
    keyword = "Humans",
    keyword = "Male",
    keyword = "Middle Aged",
    keyword = "Posture",
    keyword = "Sweat Glands",
    keyword = "Sweating",
    keyword = "Sympathetic Nervous System",
    language = "eng",
    }

  • Vaidya, J. (1992) Mediastinal tumours. Master Thesis. .
    [BibTeX]
    @mastersthesis{vaidya1992mediastinaltumours,
    author = "Vaidya, JS",
    note = "This thesis contributed towards the award of the degree of Master of Surgery - MS (General Surgery)",
    title = "Mediastinal tumours",
    year = "1992",
    keyword = "Mediastinum",
    keyword = "thymus",
    keyword = "thymoma",
    keyword = "thyroid",
    keyword = "tuberculosis",
    keyword = "germ cell tumour",
    keyword = "castleman's disease",
    keyword = "aorta",
    keyword = "schwannoma",
    conference = "University of Bombay",
    publicationstatus = "published",
    }

  • Vaidya, J., Jain, A., Diniz, R., Agshikar, N. & Dhume, V. (1986) Anti-inflammatory activity of Furosemide and Spiranolactone. IN Clinician, 50.380-384.
    [BibTeX]
    @article{vaidya1986anti-inflammatoryspiranolactone,
    author = "Vaidya, JS and Jain, A and Diniz, R and Agshikar, NV and Dhume, VG",
    journal = "Clinician",
    pages = "380--384",
    title = "Anti-inflammatory activity of Furosemide and Spiranolactone",
    volume = "50",
    year = "1986",
    issue = "11",
    }

  • Dhume, R., Vaidya, J., Dhume, R. & Gogate, M. (1984) Correlation of Muscle Activity(EMG), Muscle Excitability and Autonomic Changes induced during Meditation under Shavasana. IN Ind J Physiol Pharmacol, 85.87-87.
    [BibTeX]
    @article{dhume1984correlationshavasana,
    author = "Dhume, RR and Vaidya, JS and Dhume, RA and Gogate, MG",
    journal = "Ind J Physiol Pharmacol",
    month = "Oct",
    pages = "87--87",
    title = "Correlation of Muscle Activity(EMG), Muscle Excitability and Autonomic Changes induced during Meditation under Shavasana",
    volume = "85",
    year = "1984",
    issue = "5",
    }

  • Vaidya, J., Dhume, R., Dhume, R. & Gogate, M. (1984) Effects of Meditation on muscle excitability revealed by changes in Strength duration curve during Shavasana. IN Ind J Physiol Pharmacol, 85.86.
    [BibTeX]
    @article{vaidya1984effectsshavasana,
    author = "Vaidya, JS and Dhume, RR and Dhume, RA and Gogate, MG",
    journal = "Ind J Physiol Pharmacol",
    pages = "86",
    title = "Effects of Meditation on muscle excitability revealed by changes in Strength duration curve during Shavasana",
    volume = "85",
    year = "1984",
    issue = "5",
    }