All posts by Jayant Vaidya

TARGIT-A trial of IORT for breast cancer – Adequate follow up for a large number of patients.

Click to access the PDF file: Adequacy of follow up duration in TARGIT-A trial of targeted intraoperative radiotherapy for breast cancer

Adequacy of follow up duration in the TARGIT-A trial 

In this short paper, we provide a detailed explanation about the follow-up of the TARGIT-A trial[1, 2] and clarify how it is long enough to be relied upon to guide the application of TARGIT using Intrabeam in routine clinical practice in appropriate patients. We have explained this in the correspondence columns of the Lancet (17 May 2014)

It may appear tempting to speculate that years in the future a difference in local recurrence will become apparent and the difference in mortality that we have already seen will go away, but neither our data nor previous trial results support this speculation, which ignores our understanding about the complex natural history of breast cancer and robust literature about the toxic effects of EBRT on other organs such as the heart.

Continuing to ignore the TARGIT-A trial data can potentially put a large proportion of breast cancer patients at a significant disadvantage. Continue reading TARGIT-A trial of IORT for breast cancer – Adequate follow up for a large number of patients.

New techniques in General Surgery

I have described a new clinical diagnostic test for hernia, a method to record diastolic blood pressure without a stethoscope, and a new surgical knot.

While investigating the reasons for vomiting after surgery, we found that omitting nitrous oxide reduces its incidence

I have written about my concerns about training of doctors and surgeons and of overspecialisation that could have had fatal consequences

Here is an interesting case of gall stone ileus diagnosed from a plain abdominal film and a new disease described by my son Hrisheekesh Vaidya at age 9.

When we used the delay from symptom onset rather than clinical presentation, we found that it increases conversion rate from laparoscopic to open cholecystectomy which prompted a commentary.

I reviewed the popular must-read for surgical residents and wrote in the BMJ about alleged ‘safety-valve’ effect of spanking and people’s reaction to bad press about doctors

My commentary on systemic effect of surgery and intraoperative radiotherapy

TARGIT at St Gallen Breast Cancer symposium

TARGIT at the consensus meeting, St Gallen Breast Cancer symposium, March 2011

19 March 2011

At the 12th International St.Gallen Breast Cancer Conference 
16-19 March 2011 / St.Gallen, Switzerland,(~4200 delegates) at the Consensus session on the last day of the conference voted in favour of using intraoperative radiotherapy.

Continue reading TARGIT at St Gallen Breast Cancer symposium