Click to access the PDF file: Adequacy of follow up duration in TARGIT-A trial of targeted intraoperative radiotherapy for breast cancer
Adequacy of follow up duration in the TARGIT-A trial
In this short paper, we provide a detailed explanation about the follow-up of the TARGIT-A trial[1, 2] and clarify how it is long enough to be relied upon to guide the application of TARGIT using Intrabeam in routine clinical practice in appropriate patients. We have explained this in the correspondence columns of the Lancet (17 May 2014)
It may appear tempting to speculate that years in the future a difference in local recurrence will become apparent and the difference in mortality that we have already seen will go away, but neither our data nor previous trial results support this speculation, which ignores our understanding about the complex natural history of breast cancer and robust literature about the toxic effects of EBRT on other organs such as the heart.
Continuing to ignore the TARGIT-A trial data can potentially put a large proportion of breast cancer patients at a significant disadvantage. Continue reading TARGIT-A trial of IORT for breast cancer – Adequate follow up for a large number of patients.
TARGIT-A and TARGIT-B trials: Invited talk at the American Brachytherapy Society meeting, Las Vegas, Oct 2013
Here is a recently published viewpoint on screening mammography
Continue reading Screening mammography – a viewpoint
Case selection for TARGIT using hormone receptor status:
Continue reading Sepember 2013: TARGIT IORT at ECCO
Three papers were presented at ASTRO in Sepemeber 2013: two posters and one oral presentation.
Continue reading September 2013: TARGIT at ASTRO, USA
I have described a new clinical diagnostic test for hernia, a method to record diastolic blood pressure without a stethoscope, and a new surgical knot.
While investigating the reasons for vomiting after surgery, we found that omitting nitrous oxide reduces its incidence
I have written about my concerns about training of doctors and surgeons and of overspecialisation that could have had fatal consequences
Here is an interesting case of gall stone ileus diagnosed from a plain abdominal film and a new disease described by my son Hrisheekesh Vaidya at age 9.
When we used the delay from symptom onset rather than clinical presentation, we found that it increases conversion rate from laparoscopic to open cholecystectomy which prompted a commentary.
I reviewed the popular must-read for surgical residents and wrote in the BMJ about alleged ‘safety-valve’ effect of spanking and people’s reaction to bad press about doctors
My commentary on systemic effect of surgery and intraoperative radiotherapy
TARGIT at the consensus meeting, St Gallen Breast Cancer symposium, March 2011
19 March 2011
At the 12th International St.Gallen Breast Cancer Conference
16-19 March 2011 / St.Gallen, Switzerland,(~4200 delegates) at the Consensus session on the last day of the conference voted in favour of using intraoperative radiotherapy.
Continue reading TARGIT at St Gallen Breast Cancer symposium