The first report of targeted intraoperative radiotherapy for breast cancer

The first full paper about TARGIT was published in 2001 [1]

[1] [pdf] J. Vaidya, M. Baum, J. Tobias, D. D ‘Souza, S. Naidu, S. Morgan, M. Metexas, K. Harte, A. Sliski, and E. Thomson, “Targeted Intra-operative Radiotherapy: An Innovative Method of Treatment for Early Breast Cancer,” Annals of Oncology, vol. 12, pp. 1075-1080, 2001.
[Bibtex]
@article{vaidya2001targetedcancer,
author = "Vaidya, JS and Baum, M and Tobias, JS and D 'Souza, DP and Naidu, SV and Morgan, S and Metexas, M and Harte, KJ and Sliski, AP and Thomson, E",
journal = "Annals of Oncology",
note = "Journal English Article 12 KLUWER ACADEMIC PUBL *EARL BREAST CANC, 1995, NEW ENGL J MED, V333, P1444; BAUM M, 1997, LANCET, V349, P208; COSGROVE GR, 1997, NEUROSURGERY, V40, P518; DALE RG, 1985, BRIT J RADIOL, V58, P515; DALE RG, 1997, EUR J CANCER, V33, P1707; DENG GR, 1996, SCIENCE, V274, P2057; DOUGLAS RM, 1996, INT J RADIAT ONCOL, V36, P443; FENTIMAN IS, 1996, EUR J CANCER A, V32, P608; FISHER ER, 1992, SEMIN SURG ONCOL, V8, P161; RIBEIRO GG, 1993, CLIN ONCOL, V5, P278; VAIDYA JS, 1996, BRIT J CANCER, V74, P820; VAIDYA JS, 1998, EUR J CANCER, V34, P1143 AUG 467VT DORDRECHT Vaidya JS Univ Coll London, Acad Dept Surg, 67-73 Riding House St, London W1W 7EJ, England ANN ONCOL SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS",
pages = "1075--1080",
title = "Targeted Intra-operative Radiotherapy: An Innovative Method of Treatment for Early Breast Cancer",
volume = "12",
year = "2001",
abstract = "Introduction: We believe that conservative treatment of early breast cancer may not require radiotherapy that encompasses the whole breast. We present here the clinico-pathological basis for this view, as well as a novel therapeutic approach that allows intra-operative radiotherapy to be safely and accurately delivered to the target tissues in a standard operating theatre. The rationale: Whole-organ analysis of mastectomy specimens reveals that 80% of occult cancer foci are situated remote from the index quadrant. In contrast, over 90% of local recurrences after breast conservative therapy occur near the original tumour, even when radiotherapy is not given. Therefore, the remote occult cancer foci may be clinically irrelevant and radiotherapy to the index quadrant alone might be sufficient. A novel technique: The Photon Radiosurgery System (PRS) is an ingenious portable electron-beam driven device that can typically deliver intra-operative doses of 5-20 Gy, respectively, to 1 cm and 0.2 cm from the tumour bed over about 22 min. The pliable breast tissue - the target - wraps around the source, providing perfect conformal radiotherapy. Being soft X-rays, the dose attenuates rapidly (alpha similar to1/r(3)), reducing distant damage. Results: In our pilot study of 25 patients (age 30-80 years, T = 0.42-4.0 cm), we replaced the routine post-operative tumour bed boost with targeted intra-operative radiotherapy. There have been no major complications and no patient has developed local recurrence, although the median follow-up time is short, at 24 months. Conclusion: It is safe and feasible to deliver targeted intra- operative radiotherapy (Targit) for early breast cancer. We have begun a randomised trial - the first of its kind - comparing Targit with conventional six-week course of radiotherapy. If proven equivalent in terms of local recurrence and cosmesis, it could eliminate the need for the usual six- week course of post-operative radiotherapy",
issn = "0923-7534",
issue = "8",
keyword = "Breast",
keyword = "BREAST CANCER",
keyword = "Breast cancer/Breast conserving therap",
keyword = "BREAST-CANCER",
keyword = "cancer",
keyword = "early breast cancer",
keyword = "Intra-operative",
keyword = "intraoperative",
keyword = "Intraoperative Radiotherapy",
keyword = "IORT/Pilot/Randomised tria",
keyword = "Radiotherapy",
keyword = "surgery",
keyword = "targeted intra-operative radiotherapy",
keyword = "treatment",
keyword = "Breast cancer",
keyword = "intraoperative radiotherapy",
keyword = "1993",
keyword = "1995",
keyword = "1996",
keyword = "age",
keyword = "ALPHA",
keyword = "analysis",
keyword = "As",
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keyword = "Breast tissue",
keyword = "CM",
keyword = "COMPLICATION",
keyword = "complications",
keyword = "CONFORMAL RADIOTHERAPY",
keyword = "conservative",
keyword = "Cosmesis",
keyword = "Dale",
keyword = "Damage",
keyword = "DEVELOPED",
keyword = "DEVICE",
keyword = "dose",
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keyword = "English",
keyword = "ER",
keyword = "FOLLOW UP",
keyword = "Follow-up",
keyword = "INDEX",
keyword = "IORT",
keyword = "IRRADIATION",
keyword = "local",
keyword = "Local Recurrence",
keyword = "M",
keyword = "mastectomy",
keyword = "May",
keyword = "MED",
keyword = "MULTICENTRICITY",
keyword = "NEED",
keyword = "Netherlands",
keyword = "Neurosurgery",
keyword = "novel",
keyword = "Patient",
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keyword = "Pilot Studies",
keyword = "Pilot Study",
keyword = "PR",
keyword = "randomised trial",
keyword = "RATIONALE",
keyword = "Recurrence",
keyword = "Result",
keyword = "SAFE",
keyword = "Science",
keyword = "soft",
keyword = "SPECIMENS",
keyword = "ST",
keyword = "Standard",
keyword = "SURG",
keyword = "SYSTEM",
keyword = "target",
keyword = "TARGET TISSUES",
keyword = "TARGIT",
keyword = "technique",
keyword = "TERM",
keyword = "therapeutic",
keyword = "THERAPIES",
keyword = "therapy",
keyword = "TIME",
keyword = "Tissue",
keyword = "Tissues",
keyword = "TRIAL",
keyword = "Tumour",
keyword = "X-ray",
keyword = "X-Rays",
keyword = "BREAST CANCER",
keyword = "BREAST-CANCER",
keyword = "cancer",
keyword = "early breast cancer",
keyword = "intraoperative",
keyword = "Intraoperative Radiotherapy",
keyword = "Radiotherapy",
keyword = "TARGIT",
keyword = "treatment",
}