September 2013: TARGIT at ASTRO, USA

Three papers were presented at ASTRO in Sepemeber 2013: two posters[1][2] and one oral presentation[3].

Professor Frederik Wenz reported that  “Patients in the German centres in the TARGIT-A trial have excellent 5 year outcomes (local control >97%, overall survival !94%) in both arms of the trial”[2].

Professor Jayant Vaidya reported that “Omitting whole breast radiotherapy did not increase axillary recurrence rate in the TARGIT-A trial”[3]. and that “In addition to the avoidance of toxicity of whole breast radiotherapy, the reduction in non-breast cancer deaths may be the result of a beneficial effect of TARGIT with the hypothesis that the local effect of TARGIT on the tumor bed by inhibiting the cancer-stimulating cytokines, may spill over to reduce systemic inflammatory response to trauma and have significant long-term systemic beneficial effects, that might be protective against cardiac and cancer mortality[1].

[1] [pdf] [doi] J. Vaidya, M. Bulsara, F. Wenz, S. Massarut, D. Joseph, J. Tobias, N. Williams, and M. Baum, “The Lower Non-Breast Cancer Mortality With TARGIT in the TARGIT-A Trial Could Be a Systemic Effect of TARGIT on Tumor Microenvironment,” International Journal of Radiation Oncology*Biology*Physics, vol. 87, p. S240, 2013.
[Bibtex]
@article{vaidya2013themicroenvironment,
author = "Vaidya, JS and Bulsara, M and Wenz, F and Massarut, S and Joseph, D and Tobias, J and Williams, N and Baum, M",
journal = "International Journal of Radiation Oncology*Biology*Physics",
month = "Oct",
note = "",
pages = "S240",
title = "The Lower Non-Breast Cancer Mortality With TARGIT in the TARGIT-A Trial Could Be a Systemic Effect of TARGIT on Tumor Microenvironment",
url = "http://www.sciencedirect.com/science/article/pii/S0360301613012935",
volume = "87",
year = "2013",
doi = "10.1016/j.ijrobp.2013.06.623",
issn = "0360-3016",
issue = "2, Supplement",
conference = "Proceedings of the American Society for Radiation Oncology 55th Annual Meeting ASTRO's 55th Annual Metting",
day = "1",
}
[2] [pdf] [doi] F. Wenz, J. Vaidya, S. Pigorsch, P. Feyer, C. Roedel, C. Belka, J. Fleckenstein, M. Bremer, D. Joseph, and M. Baum, “Local Recurrence and Survival for the German Centers in the TARGIT-A (TARGeted Intraoperative Radiation Therapy – Alone) Trial,” International Journal of Radiation Oncology*Biology*Physics, vol. 87, p. S241, 2013.
[Bibtex]
@article{wenz2013localtrial,
author = "Wenz, F and Vaidya, JS and Pigorsch, S and Feyer, P and Roedel, C and Belka, C and Fleckenstein, J and Bremer, M and Joseph, D and Baum, M",
journal = "International Journal of Radiation Oncology*Biology*Physics",
month = "Oct",
note = "",
pages = "S241",
title = "Local Recurrence and Survival for the German Centers in the TARGIT-A (TARGeted Intraoperative Radiation Therapy - Alone) Trial",
url = "http://www.sciencedirect.com/science/article/pii/S0360301613012959",
volume = "87",
year = "2013",
doi = "10.1016/j.ijrobp.2013.06.625",
issn = "0360-3016",
issue = "2, Supplement",
conference = "Proceedings of the American Society for Radiation Oncology 55th Annual Meeting ASTRO's 55th Annual Metting",
day = "1",
}
[3] [pdf] [doi] J. Vaidya, F. Wenz, M. Bulsara, S. Massarut, J. Tobias, N. Williams, D. Joseph, and M. Baum, “Omitting Whole Breast Radiation Therapy did not Increase Axillary Recurrence in the TARGIT-A Trial,” International Journal of Radiation Oncology*Biology*Physics, vol. 87, p. S7, 2013.
[Bibtex]
@article{vaidya2013omittingtrial,
author = "Vaidya, JS and Wenz, F and Bulsara, M and Massarut, S and Tobias, J and Williams, N and Joseph, D and Baum, M",
journal = "International Journal of Radiation Oncology*Biology*Physics",
month = "Oct",
note = "",
pages = "S7",
title = "Omitting Whole Breast Radiation Therapy did not Increase Axillary Recurrence in the TARGIT-A Trial",
url = "http://www.sciencedirect.com/science/article/pii/S0360301613006950",
volume = "87",
year = "2013",
doi = "10.1016/j.ijrobp.2013.06.025",
issn = "0360-3016",
issue = "2, Supplement",
conference = "Proceedings of the American Society for Radiation Oncology 55th Annual Meeting ASTRO's 55th Annual Metting",
day = "1",
}