Category: Targeted Intraoperative Radiotherapy for Breast Cancer
Articles I’ve written about Targeted Intraoperative Radiotherapy (TARGIT)
In the last 18 months further evidence has emerged supporting the use of TARGIT IORT for breast cancer.
The Full Report of the TARGIT-A trial was published in the HTA Journals in September 2016.
This contains several additional analyses including a) subgroup analysis as per tumour and patient characteristics b) formal health economic analysis c) analysis of the earliest cohort of patients with a median follow up of 5 years had the same results as the main trial, viz. – that TARGIT and EBRT had similar breast cancer control and non-breast-cancer deaths were fewer with TARGIT.
HTA Journals 18 June 2016
Full report of TARGIT-A trial comparing Intrabeam TARGIT IORT vs traditional radiotherapy over several weeks for early breast cancer
An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery for women with early-stage breast cancer (the TARGIT-A trial). Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Saunders C, Brew-Graves C, Potyka I, Morris S, Vaidya HJ, Williams NR, Baum M. Health Technology Assessment 2016;20(73) — PDF download —
The publications from 2015-16, after the main results of the TARGIT-A trial were published as well as the initial publications (listed at the end of file)
are available in the file:
[download id=”1365″]
To read, right-click this Download link to the pdf file, and save the file on your computer.
Then open using Acrobat Reader.
If you cannot see the Bookmarks pane,
click on View profile, then show/hide – navigation panes and then click on Bookmarks.
Now you should see all the 16 bookmarks and navigate through the 16 papers.
To read the list of 66 selected initial original publications please see [download id=”1361″] The front page of this website has links to the full text PDFs of important publications http://www.targit.org.uk
The list is also shown below:
Further evidence supporting adoption TARGIT IORT in routine clinical practice:
16 publications in major journals the last 18 months from USA, Europe and Australia
1. BMC Cancer Nov 2014
French Study of 12,025 patients: Over 50% of patients having breast conservation are suitable for TARGIT IORT
2. Breast Surg Mar-Apr 2015
Intraoperative radiotherapy of the breast for early-stage breast cancer: ready for primetime
3. Br J Surgery May 2015
Intraoperative radiotherapy in early breast cancer
4. Ecancermedicalscience Mar 2015
Is IORT ready for roll-out? [Yes]
5. Red Journal Jun 2015
Pride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of Targeted Intraoperative Radiation Therapy for Breast Cancer
Red Journal Aug 2015- Editorial by the Red Journal
“…..Many careers have been built around fractionated radiation therapy for breast cancer, and it comprises a substantial proportion of the practice of the average contemporary radiation oncologist. Depending on your perspective, intraoperative radiation therapy is thus either a very serious threat or a quantum leap forward.”
6. Breast Care 15 July 2015
Accelerated Partial Breast Irradiation in Clinical Practice
7. American J Surg Oct 2016
IORT with its low rate of LR and wound complications may be a reasonable alternative to whole breast irradiation for early-stage breast cancer, regardless of age.
8. Chapter in “Short Course Breast Radiotherapy” 1 Jan 2016
A Risk-Adapted Approach to Breast Radiation Using Targeted Intraoperative Radiotherapy (TARGIT)
9. Oncogene 15 Feb 2016
Radiotherapy-induced miR-223 prevents relapse of breast cancer by targeting the EGF pathway.
10. Oncology 15 April 2016
[Low] Frequency of Whole-Breast Radiation Therapy Following Intraoperative Radiation Therapy Due to Criteria Identified by Lumpectomy
11. Lancet 23 April 2016
A meta-analysis of GEC-ESTRO + TARGIT-A trials show Partial Breast Irradiation (PBI) has similar breast cancer control as Whole Breast Irradiation (WBI), and fewer deaths from other causes.
12. Red Journal 30 April 2016
Better Quality of Life with TARGIT
13. Lancet 7 May 2016:
Intraoperative radiation therapy for breast cancer: a patient’s view
14. Annals of Surgical Oncology 9 May 2016
TARGIT-R (Retrospective): North American Experience [of nearly 1000 patients] with Intraoperative Radiation Using Low-Kilovoltage X-Rays [Intrabeam] for Breast Cancer
15. BMJ Open 10 May 2016
TARGIT IORT radiotherapy during lumpectomy for breast cancer could save millions of travel miles & tonnes of CO2. …plus free up thousands of hours for women with early stage breast cancer, every year.
Video Abstract
Full paper
Press release by the BMJ
16. Red Journal 13 May 2016
Mortality reduction with Partial Breast Irradiation: A meta-analysis of randomised controlled trials
An estimated 20,000 patients have already been treated with Intrabeam TARGIT IORT
Worldwide Adoption of Intrabeam TARGIT IORT
“Our meta-analysis of 5-year data from published randomized trials of partial breast irradiation (PBI, alone or within a risk-adapted approach) vs. whole breast irradiation (WBI) for invasive breast cancer treated with lumpectomy, found no difference in breast cancer mortality (n=4489,difference 0.000%(95%CI -0.7 to +0.7),p=0.972). PBI was better than WBI for non-breast cancer mortality (n=4231,difference 1.1% (95%CI -2.1% to -0.2%),p=0.023), and total mortality (difference 1.3% (95%CI -2.5% – 0.0%),p=0.05), leading to a 25% relative risk reduction.”
In the figure below, PBI means Partial Breast Irradiation i.e., radiation only to the area near the tumour rather than the whole breast (Whole Breast Irradiation WBI).
The red diamond shows the overall effect from several trials with over 4000 patients. If the diamond sits on the vertical line, it means there is no effect – and if it is on the left it means that treatment is better for the patient.
So PBI (using TARGIT IORT as a single shot radiation at the time of lumpectomy for breast cancer, for example) reduces mortality, possibly by avoiding irradiation of vital organs, while maintaining cancer control.
Full paper can be accessed at:
www.sciencedirect.com/science/article/pii/S0360301616302000
http://www.redjournal.org/article/S0360-3016(16)30200-0/pdf
25 July 2014 : NICE issued a press release that prompted the following media coverage of TARGIT IORT for breast cancer with Intrabeam
TARGIT IORT for breast cancer using Intrabeam – TV / Radio News and Interviews with Professor Jeffrey Tobias and Professor Jayant Vaidya
Individual ClipsBBC Radio 4: The Today Programme
Sophie Hutchinson reports
Interview with Professor Jeffrey Tobias
TV Interviews
[Click here to see all the videos on YouTube, as a playlist or a single video]
ITV Good Morning Britain [click if video fails to load]
Sky Breakfast News [click if video fails to load]
BBC Breakfast
BBC News Channel [click if video fails to load]
BBC Evening News [click if video fails to load]
ITV Evening News
Newspaper articles
Single-dose radiotherapy eases breast cancer stress
The Times
Thousands of women with breast cancer will be offered a new form of radiotherapy to spare them weeks of gruelling treatment. The half-hour treatment is carried out at the same time as surgery, and trials showed that women found it easier, quicker and less …
Half-hour breast cancer treatment can replace weeks of radiotherapy …
Daily Mail – Jul 24, 2014
Tens of thousands of women with breast cancer could soon be offered a single 30-minute shot of radiotherapy, sparing them weeks of exhausting treatment. The new treatment called intrabeam radiotherapy is delivered during surgery, while the patient is still …
NICE gives go ahead to intrabeam radiotherapy for breast cancer
The BMJ – Jul 29, 2014
Intrabeam radiotherapy, a single dose treatment used during surgery for patients with breast cancer, has been given the go ahead for use in the NHS in England.
Breast cancer patients to get new quick radiotherapy treatment
Telegraph.co.uk – Jul 25, 2014
Trials have shown that cancer returned in less than five years in three per cent of women treated with Intrabeam compared with one per cent of women who had traditional radiotherapy. However overall survival five years after diagnosis was not significantly …
Single-dose radiotherapy could transform breast cancer treatment
The Guardian – Jul 25, 2014
Intrabeam radiotherapy has been given a provisional go-ahead for NHS use by the health finance watchdog. In draft guidance, the National Institute for Health and Care excellence (Nice) said the treatment option should be considered for people with early …
NHS approves one-shot breast cancer therapy treatment
The Independent – Jul 25, 2014
‘Intrabeam‘ radiotherapy involves injecting a single shot of radiation inside the breast during surgery, meaning patients with early breast cancer do not have to keep attending treatment sessions. Early stage breast cancer is classed as such when the tumour is …
Cancer therapy on offer more widely
Swindon Advertiser – Jul 25, 2014
PIONEERING breast cancer treatment will be available to up to 150 women with any type of tumour and of any age across Swindon on the NHS, it has been announced. Earlier this year, the Great Western Hospital launched an appeal to fund new …
UK to adopt Indian-origin expert’s breast cancer treatment
Hindustan Times – 17 hours ago
Carole Longson, director National Institute for Health and Care Excellence, said on Friday: “Unlike regular radiotherapy, with the intrabeam radiotherapy system only one dose is required. This single dose is given at the same time as surgery, eliminating the …
News Articles on TV channels
BBC 6pm News: Breast cancer: One-shot therapy gets NHS nod
A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS.
BBC TV: Marcelle Bernstein: No side effects from breast cancer treatment
Marcelle Bernstein talks about the pioneering breast cancer treatment she received two years ago which is to be offered on the NHS.
BBC: Breast cancer: One-shot therapy gets NHS nod 
Health / 25 July 2014
A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS. The dose…
More News coverage
New radiotherapy ‘eliminates need for numerous visits’
ITV News – Jul 24, 2014
Unlike regular radiotherapy, with the Intrabeam Radiotherapy System only one dose is required. This single dose is given at the same time as surgery, eliminating the need for numerous hospital visits. Regular radiotherapy typically requires numerous doses …
‘Innovative’ radiotherapy for breast cancer sufferers
ITV News – Jul 24, 2014
The National Institute for Health and Care excellence (Nice) gave intrabeam radiotherapy the seal of approval for use on the NHS. The treatment involves administering a single dose of radiotherapy to patients during surgery. A single dose of radiotherapy …
Single dose radiotherapy approved for breast cancer sufferers
ITV News – Jul 24, 2014
An “innovative” form of radiotherapy for patients in the early stages of breast cancer has been approved on the NHS. The National Institute for Health and Care excellence (Nice) gave the green light for “revolutionary” intrabeam radiotherapy. Share · Tweet …
Single-Shot Radiotherapy For Breast Cancer
Sky News – Jul 24, 2014
Intrabeam radiotherapy has been given provisional go-ahead for NHS use by the National Institute for Health and Care excellence (Nice). In new draft guidance, Nice said the treatment option should be considered for people with early stage breast cancer.
For breast cancer patients like me, the age of refinement is truly transforming
The Guardian – Jul 25, 2014
Single-dose radiotherapy could transform breast cancer treatment. Intrabeam radiotherapy, which has go-ahead for NHS use, is given during surgery, eliminating need for additional hospital trips. Published: 25 Jul 2014 …
Intrabeam radiotherapy, boon for breast cancer patients
Delhi Daily News – Jul 25, 2014
Professor Carole Longson, director of health technology evaluation at Nice, said in a statement: “It’s still a new treatment – so far only six centres in the UK have used the Intrabeam Radiotherapy System to treat early breast cancer. Because it is still relatively …
‘Revolutionary’ new cancer therapy
Harborough Mail – Jul 24, 2014
Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional …
‘One stop’ breast cancer surgery wins NHS go-ahead
Express.co.uk – Jul 25, 2014
The revolutionary laser treatment could transform the way doctors treat early stage breast cancer and save the health service £50million. Charities hailed the decision as “exciting” and said that often the Intrabeam radiotherapy is the only treatment women …
One dose therapy for some breast cancer patients
WebMD.Boots.com – Jul 25, 2014
25th July 2014 – A new one-shot radiotherapy treatment for breast cancer patients has been provisionally recommended for use by the NHS in England. Intraoperative radiotherapy (IORT) using the Intrabeam Radiotherapy System, is administered from inside …
‘Revolutionary’ breast cancer therapy wins NHS backing
Halifax Evening Courier – Jul 25, 2014
Tens of thousands of breast cancer sufferers could benefit from a “revolutionary” new type of radiotherapy delivered during surgery. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use for people with early-stage breast cancer.
NICE to OK single-shot radiotherapy for breast cancer
PharmaTimes – Jul 24, 2014
NICE has, however, stipulated that doctors must fully inform patients of all their treatment choices so that they can make informed decisions, enter details about all of those treatment with intrabeam radiotherapy onto a national register, and audit, review and …
Breast cancer: ‘revolutionary’ one-shot treatment for NHS
The Week UK – Jul 25, 2014
“It’s still a new treatment – so far only six centres in the UK have used the Intrabeam radiotherapy system to treat early breast cancer,” says Professor Carole Longson, director of health technology evaluation at Nice. “Because it is still relatively new it is only …
Breakthrough breast cancer treatment given the go-ahead
The Voice of Russia – Jul 25, 2014
The new treatment is a single dose of radiotherapy administered during a patient’s cancer surgery that will eliminate the need for multiple radiotherapy follow-up sessions. Intrabeam radiotherapy has been given the go-ahead for NHS use and will soon be …
New breast cancer treatment can tackle disease in one day
Irish Mirror – Jul 25, 2014
Thousands of women with breast cancer could benefit from a new treatment that tackles the disease in a day. Intrabeam radiotherapy is an X-ray device that blasts a high dose of radiation directly into a tumour. Draft guidance from the National Institute for …
News digest July 25 2014
Nursing Standard – Jul 25, 2014
Tens of thousands of breast cancer patients could benefit from a new type of radiotherapy that could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use …
Breast cancer zapped by fast new radiotherapy
Shiny Shiny – Jul 25, 2014
After a tumour is removed, doctors use the intrabeam radiotherapy system to insert a probe into the breast and deliver a concentrated dose of radiation directly to the site of the malignancy. A trial on 2000 women led by a UK team found that this had a similar …
Breast cancer: Single-shot therapy to be offered on NHS
Metro – Jul 25, 2014
A new treatment for breast cancer that consists of a single shot is set to be available on the NHS. The technique, known as intra-operative radiation, concentrates a dose of radiation that is injected from inside the breast during surgery, once a tumour has been …
NHS Approves “One Shot” Cancer Blast to Replace Weeks of Radiotherapy
Gizmodo UK – Jul 25, 2014
The group that decides what treatments are allowed to be dished out by the NHS has approved a new form of radiation treatment, with the intra-operative radiation therapy hopefully providing a one-time blast to obliterate the remnants of breast cancer in those …
‘Revolutionary’ breast cancer therapy wins NHS backing
Todmorden Today – Jul 25, 2014
Tens of thousands of breast cancer sufferers could benefit from a “revolutionary” new type of radiotherapy delivered during surgery. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use for people with early-stage breast cancer.
Breast cancer: One-shot therapy gets NHS nod
The Guardian Nigeria – Jul 24, 2014
A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS. The dose of radiation is delivered from inside the breast, once a tumour has been removed in surgery. It would benefit up to …
‘Revolutionary’ single-dose breast cancer treatment begins in UK
BreakingNews.ie – Jul 24, 2014
Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment.Intrabeam radiotherapy has been given a provisional …
Single-Shot Radiotherapy For Breast Cancer
City Talk 105.9 – Jul 24, 2014
Intrabeam radiotherapy has been given provisional go-ahead for NHS use by the National Institute for Health and Care excellence (Nice). In new draft guidance, Nice said the treatment option should be considered for people with early stage breast cancer.
‘Revolutionary’ new cancer therapy
Belfast Telegraph – Jul 24, 2014
Intrabeam radiotherapy has been given a provisional go-ahead for NHS use by the health finance watchdog. In new draft guidance, the National Institute for Health and Care excellence (Nice) said that the treatment option should be considered for people with …
cancer therapy
ITN – Jul 25, 2014
Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional …
NHS gave a green signal for the revolutionary new breast cancer therapy
The Football Examiner – Jul 24, 2014
Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional …
New radiotherapy ‘eliminates need for numerous visits’
ITV News – Jul 24, 2014
Unlike regular radiotherapy, with the Intrabeam Radiotherapy System only one dose is required. This single dose is given at the same time as surgery, eliminating the need for numerous hospital visits. Regular radiotherapy typically requires numerous doses …
-
Health – My Free Britain
www.myfreebritain.com/health
Single-dose radiotherapy eases breast cancer stress
The Times
Thousands of women with breast cancer will be offered a new form of radiotherapy to spare them weeks of gruelling treatment. The half-hour treatment is carried out at the same time as surgery, and trials showed that women found it easier, quicker and less …
Half-hour breast cancer treatment can replace weeks of radiotherapy …
Daily Mail – Jul 24, 2014
Tens of thousands of women with breast cancer could soon be offered a single 30-minute shot of radiotherapy, sparing them weeks of exhausting treatment. The new treatment called intrabeam radiotherapy is delivered during surgery, while the patient is still …
NICE gives go ahead to intrabeam radiotherapy for breast cancer
The BMJ – Jul 29, 2014
Intrabeam radiotherapy, a single dose treatment used during surgery for patients with breast cancer, has been given the go ahead for use in the NHS in England.
Breast cancer patients to get new quick radiotherapy treatment
Telegraph.co.uk – Jul 25, 2014
Trials have shown that cancer returned in less than five years in three per cent of women treated with Intrabeam compared with one per cent of women who had traditional radiotherapy. However overall survival five years after diagnosis was not significantly …
Single-dose radiotherapy could transform breast cancer treatment
The Guardian – Jul 25, 2014
Intrabeam radiotherapy has been given a provisional go-ahead for NHS use by the health finance watchdog. In draft guidance, the National Institute for Health and Care excellence (Nice) said the treatment option should be considered for people with early …
NHS approves one-shot breast cancer therapy treatment
The Independent – Jul 25, 2014
‘Intrabeam‘ radiotherapy involves injecting a single shot of radiation inside the breast during surgery, meaning patients with early breast cancer do not have to keep attending treatment sessions. Early stage breast cancer is classed as such when the tumour is …
Cancer therapy on offer more widely
Swindon Advertiser – Jul 25, 2014
PIONEERING breast cancer treatment will be available to up to 150 women with any type of tumour and of any age across Swindon on the NHS, it has been announced. Earlier this year, the Great Western Hospital launched an appeal to fund new …
UK to adopt Indian-origin expert’s breast cancer treatment
Hindustan Times – 17 hours ago
Carole Longson, director National Institute for Health and Care Excellence, said on Friday: “Unlike regular radiotherapy, with the intrabeam radiotherapy system only one dose is required. This single dose is given at the same time as surgery, eliminating the …
News Articles on TV channels
BBC 6pm News: Breast cancer: One-shot therapy gets NHS nod
A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS.
BBC TV: Marcelle Bernstein: No side effects from breast cancer treatment
Marcelle Bernstein talks about the pioneering breast cancer treatment she received two years ago which is to be offered on the NHS.
BBC: Breast cancer: One-shot therapy gets NHS nod
Health / 25 July 2014
A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS. The dose…
More News coverage
New radiotherapy ‘eliminates need for numerous visits’
ITV News – Jul 24, 2014
Unlike regular radiotherapy, with the Intrabeam Radiotherapy System only one dose is required. This single dose is given at the same time as surgery, eliminating the need for numerous hospital visits. Regular radiotherapy typically requires numerous doses …
‘Innovative’ radiotherapy for breast cancer sufferers
ITV News – Jul 24, 2014
The National Institute for Health and Care excellence (Nice) gave intrabeam radiotherapy the seal of approval for use on the NHS. The treatment involves administering a single dose of radiotherapy to patients during surgery. A single dose of radiotherapy …
Single dose radiotherapy approved for breast cancer sufferers
ITV News – Jul 24, 2014
An “innovative” form of radiotherapy for patients in the early stages of breast cancer has been approved on the NHS. The National Institute for Health and Care excellence (Nice) gave the green light for “revolutionary” intrabeam radiotherapy. Share · Tweet …
Single-Shot Radiotherapy For Breast Cancer
Sky News – Jul 24, 2014
Intrabeam radiotherapy has been given provisional go-ahead for NHS use by the National Institute for Health and Care excellence (Nice). In new draft guidance, Nice said the treatment option should be considered for people with early stage breast cancer.
For breast cancer patients like me, the age of refinement is truly transforming
The Guardian – Jul 25, 2014
Single-dose radiotherapy could transform breast cancer treatment. Intrabeam radiotherapy, which has go-ahead for NHS use, is given during surgery, eliminating need for additional hospital trips. Published: 25 Jul 2014 …
Intrabeam radiotherapy, boon for breast cancer patients
Delhi Daily News – Jul 25, 2014
Professor Carole Longson, director of health technology evaluation at Nice, said in a statement: “It’s still a new treatment – so far only six centres in the UK have used the Intrabeam Radiotherapy System to treat early breast cancer. Because it is still relatively …
‘Revolutionary’ new cancer therapy
Harborough Mail – Jul 24, 2014
Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional …
‘One stop’ breast cancer surgery wins NHS go-ahead
Express.co.uk – Jul 25, 2014
The revolutionary laser treatment could transform the way doctors treat early stage breast cancer and save the health service £50million. Charities hailed the decision as “exciting” and said that often the Intrabeam radiotherapy is the only treatment women …
One dose therapy for some breast cancer patients
WebMD.Boots.com – Jul 25, 2014
25th July 2014 – A new one-shot radiotherapy treatment for breast cancer patients has been provisionally recommended for use by the NHS in England. Intraoperative radiotherapy (IORT) using the Intrabeam Radiotherapy System, is administered from inside …
‘Revolutionary’ breast cancer therapy wins NHS backing
Halifax Evening Courier – Jul 25, 2014
Tens of thousands of breast cancer sufferers could benefit from a “revolutionary” new type of radiotherapy delivered during surgery. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use for people with early-stage breast cancer.
NICE to OK single-shot radiotherapy for breast cancer
PharmaTimes – Jul 24, 2014
NICE has, however, stipulated that doctors must fully inform patients of all their treatment choices so that they can make informed decisions, enter details about all of those treatment with intrabeam radiotherapy onto a national register, and audit, review and …
Breast cancer: ‘revolutionary’ one-shot treatment for NHS
The Week UK – Jul 25, 2014
“It’s still a new treatment – so far only six centres in the UK have used the Intrabeam radiotherapy system to treat early breast cancer,” says Professor Carole Longson, director of health technology evaluation at Nice. “Because it is still relatively new it is only …
Breakthrough breast cancer treatment given the go-ahead
The Voice of Russia – Jul 25, 2014
The new treatment is a single dose of radiotherapy administered during a patient’s cancer surgery that will eliminate the need for multiple radiotherapy follow-up sessions. Intrabeam radiotherapy has been given the go-ahead for NHS use and will soon be …
New breast cancer treatment can tackle disease in one day
Irish Mirror – Jul 25, 2014
Thousands of women with breast cancer could benefit from a new treatment that tackles the disease in a day. Intrabeam radiotherapy is an X-ray device that blasts a high dose of radiation directly into a tumour. Draft guidance from the National Institute for …
News digest July 25 2014
Nursing Standard – Jul 25, 2014
Tens of thousands of breast cancer patients could benefit from a new type of radiotherapy that could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use …
Breast cancer zapped by fast new radiotherapy
Shiny Shiny – Jul 25, 2014
After a tumour is removed, doctors use the intrabeam radiotherapy system to insert a probe into the breast and deliver a concentrated dose of radiation directly to the site of the malignancy. A trial on 2000 women led by a UK team found that this had a similar …
Breast cancer: Single-shot therapy to be offered on NHS
Metro – Jul 25, 2014
A new treatment for breast cancer that consists of a single shot is set to be available on the NHS. The technique, known as intra-operative radiation, concentrates a dose of radiation that is injected from inside the breast during surgery, once a tumour has been …
NHS Approves “One Shot” Cancer Blast to Replace Weeks of Radiotherapy
Gizmodo UK – Jul 25, 2014
The group that decides what treatments are allowed to be dished out by the NHS has approved a new form of radiation treatment, with the intra-operative radiation therapy hopefully providing a one-time blast to obliterate the remnants of breast cancer in those …
‘Revolutionary’ breast cancer therapy wins NHS backing
Todmorden Today – Jul 25, 2014
Tens of thousands of breast cancer sufferers could benefit from a “revolutionary” new type of radiotherapy delivered during surgery. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use for people with early-stage breast cancer.
Breast cancer: One-shot therapy gets NHS nod
The Guardian Nigeria – Jul 24, 2014
A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS. The dose of radiation is delivered from inside the breast, once a tumour has been removed in surgery. It would benefit up to …
‘Revolutionary’ single-dose breast cancer treatment begins in UK
BreakingNews.ie – Jul 24, 2014
Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment.Intrabeam radiotherapy has been given a provisional …
Single-Shot Radiotherapy For Breast Cancer
City Talk 105.9 – Jul 24, 2014
Intrabeam radiotherapy has been given provisional go-ahead for NHS use by the National Institute for Health and Care excellence (Nice). In new draft guidance, Nice said the treatment option should be considered for people with early stage breast cancer.
‘Revolutionary’ new cancer therapy
Belfast Telegraph – Jul 24, 2014
Intrabeam radiotherapy has been given a provisional go-ahead for NHS use by the health finance watchdog. In new draft guidance, the National Institute for Health and Care excellence (Nice) said that the treatment option should be considered for people with …
cancer therapy
ITN – Jul 25, 2014
Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional …
NHS gave a green signal for the revolutionary new breast cancer therapy
The Football Examiner – Jul 24, 2014
Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional …
New radiotherapy ‘eliminates need for numerous visits’
ITV News – Jul 24, 2014
Unlike regular radiotherapy, with the Intrabeam Radiotherapy System only one dose is required. This single dose is given at the same time as surgery, eliminating the need for numerous hospital visits. Regular radiotherapy typically requires numerous doses …
-
Health – My Free Britain
www.myfreebritain.com/health
Click to access the PDF file: Adequacy of follow up duration in TARGIT-A trial of targeted intraoperative radiotherapy for breast cancer
Adequacy of follow up duration in the TARGIT-A trial
In this short paper, we provide a detailed explanation about the follow-up of the TARGIT-A trial[1, 2] and clarify how it is long enough to be relied upon to guide the application of TARGIT using Intrabeam in routine clinical practice in appropriate patients. We have explained this in the correspondence columns of the Lancet (17 May 2014)
It may appear tempting to speculate that years in the future a difference in local recurrence will become apparent and the difference in mortality that we have already seen will go away, but neither our data nor previous trial results support this speculation, which ignores our understanding about the complex natural history of breast cancer and robust literature about the toxic effects of EBRT on other organs such as the heart.
Continuing to ignore the TARGIT-A trial data can potentially put a large proportion of breast cancer patients at a significant disadvantage.
TARGIT-A and TARGIT-B trials: Invited talk at the American Brachytherapy Society meeting, Las Vegas, Oct 2013
Case selection for TARGIT using hormone receptor status:
Three papers were presented at ASTRO in Sepemeber 2013: two posters and one oral presentation.
TARGIT at the consensus meeting, St Gallen Breast Cancer symposium, March 2011
19 March 2011
At the 12th International St.Gallen Breast Cancer Conference 16-19 March 2011 / St.Gallen, Switzerland,(~4200 delegates) at the Consensus session on the last day of the conference voted in favour of using intraoperative radiotherapy.
The first full paper about TARGIT was published in 2001